PMID- 37306802
OWN - NLM
STAT- MEDLINE
DCOM- 20230921
LR  - 20230923
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Print)
IS  - 0937-941X (Linking)
VI  - 34
IP  - 10
DP  - 2023 Oct
TI  - Causal relationship between type 2 diabetes mellitus and bone mineral density: a 
      Mendelian randomization study in an East Asian population.
PG  - 1719-1727
LID - 10.1007/s00198-023-06807-6 [doi]
AB  - It remains unclear whether the relationship between type 2 diabetes mellitus 
      (T2DM) and bone mineral density (BMD) reflects causality in East Asian 
      populations. Herein, a Mendelian randomization study conducted in East Asian 
      population enhances the current clinical cognition that T2DM is not associated 
      with reduction in BMD. PURPOSE: A Mendelian randomization (MR) approach was 
      utilized to investigate the relationship between type 2 diabetes mellitus (T2DM) 
      and bone mineral density (BMD) in East Asian populations. METHODS: Genome-wide 
      association study summary data from BioBank Japan were used to identify genetic 
      variants strongly related to T2DM risk (36,614 cases and 155,150 controls) and 
      osteoporosis (7788 cases and 204,665 controls). Heel BMD GWAS data of 1260 East 
      Asian people from ieu open gwas project was considered as a second outcome. 
      Inverse variance-weighted (IVW) analysis was mainly applied; MR-Egger and the 
      weighted median were also used to obtain robust estimates. A series of 
      sensitivity analyses including Cochran's Q test, MR-Egger regression, and 
      leave-one-out analysis were used to detect pleiotropy or heterogeneity. RESULTS: 
      In the main analysis, IVW estimates indicated that T2DM significantly associated 
      with the risk of osteoporosis (odds ratio = 0.92, 95% CI: 0.86-0.99, p = 0.016) 
      and with higher BMD (OR: 1.25, 95% CI: 1.06-1.46, p = 6.49 x 10(-3)). Results of 
      comprehensive sensitivity analysis were consistent with the main causality 
      estimate. Horizontal pleiotropy and heterogeneity were absent in our MR study. 
      CONCLUSIONS: T2DM is not associated with reduction in BMD in terms of genetic 
      polymorphism in East Asian populations.
CI  - (c) 2023. The Author(s).
FAU - Huang, Guiwu
AU  - Huang G
AD  - Department of Joint Surgery, The First Affiliated Hospital of Sun Yat-Sen 
      University, Sun Yat-Sen University, Guangzhou, China.
AD  - Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, The First 
      Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Chen, Xiong
AU  - Chen X
AD  - Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Chen, Yanbo
AU  - Chen Y
AD  - Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      107 Yanjiangxi Road, Guangzhou, Guangdong Province, 510120, China.
FAU - Liu, Wenzhou
AU  - Liu W
AD  - Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      107 Yanjiangxi Road, Guangzhou, Guangdong Province, 510120, China.
FAU - Chen, Chen
AU  - Chen C
AD  - Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      107 Yanjiangxi Road, Guangzhou, Guangdong Province, 510120, China.
FAU - Song, Weidong
AU  - Song W
AD  - Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      107 Yanjiangxi Road, Guangzhou, Guangdong Province, 510120, China. 
      songwd@mail.sysu.edu.cn.
FAU - Zeng, Gang
AU  - Zeng G
AD  - Department of Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      107 Yanjiangxi Road, Guangzhou, Guangdong Province, 510120, China. 
      zengg5@mail.sysu.edu.cn.
LA  - eng
GR  - 2022A1515012334/Natural Science Foundation of Guangdong Province for 
      Distinguished Young Scholars/
PT  - Journal Article
DEP - 20230612
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
SB  - IM
MH  - Humans
MH  - Bone Density/genetics
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology/genetics
MH  - East Asian People
MH  - Genome-Wide Association Study
MH  - Mendelian Randomization Analysis
MH  - *Osteoporosis/epidemiology/genetics
MH  - Polymorphism, Single Nucleotide
PMC - PMC10511588
OTO - NOTNLM
OT  - Bone mineral density
OT  - Mendelian randomization
OT  - Osteoporosis
OT  - Type 2 diabetes mellitus
COIS- None.
EDAT- 2023/06/12 13:07
MHDA- 2023/09/21 06:42
PMCR- 2023/06/12
CRDT- 2023/06/12 11:08
PHST- 2022/07/15 00:00 [received]
PHST- 2023/05/25 00:00 [accepted]
PHST- 2023/09/21 06:42 [medline]
PHST- 2023/06/12 13:07 [pubmed]
PHST- 2023/06/12 11:08 [entrez]
PHST- 2023/06/12 00:00 [pmc-release]
AID - 10.1007/s00198-023-06807-6 [pii]
AID - 6807 [pii]
AID - 10.1007/s00198-023-06807-6 [doi]
PST - ppublish
SO  - Osteoporos Int. 2023 Oct;34(10):1719-1727. doi: 10.1007/s00198-023-06807-6. Epub 
      2023 Jun 12.