PMID- 37308436
OWN - NLM
STAT- MEDLINE
DCOM- 20230614
LR  - 20230614
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 38
IP  - 6
DP  - 2022 Nov
TI  - [Alleviating effects of hydrogen on hyperhomocysteinemia and fatty liver induced 
      by high-methionine diet].
PG  - 787-792
LID - 10.12047/j.cjap.6382.2022.143 [doi]
AB  - Objective: To investigate the alleviating effect of hydrogen (H(2)) on 
      homocysteine (Hcy) levels and non alcoholic fatty liver in rats with 
      hyperhomocysteinemia (HHcy). Methods: After one week of adaptive feeding, Wistar 
      rats were randomly divided into three groups: the general diet group (CHOW), the 
      high methionine group (HMD), and the high methionine plus hydrogen rich water 
      group (HMD+HRW), with 8 rats in each group. The CHOW group was fed with AIN-93G 
      feed, while the HMD and HMD+HRW groups were fed with AIN-93G+2% methionine feed 
      to construct an HHcy model. The HMD+HRW group was also gavaged with hydrogen rich 
      water (3 ml/animal, twice a day, with a hydrogen concentration of 0.8 mmol/L), 
      and body weight data were recorded. After 6 weeks of feeding, the plasma and 
      liver samples were processed and collected. The plasma homocysteine (Hcy) and 
      lipid contents of each group were measured, and the histological morphology of 
      the liver was observed. The activities of key enzymes in the Hcy metabolism 
      pathway and mRNA expression were detected in the liver. Results: Compared with 
      the CHOW group rats, the Hcy level in the blood of HMD rats was significantly 
      increased significantly (P＜0.05). Pathological tissue sections showed liver 
      enlargement, injury, and fatty liver in the rats; Compared with the HMD group 
      rats, the HMD+HRW group rats showed a significant decrease in Hcy in the blood, 
      reduced liver damage, and increased Hcy metabolism key enzyme activity and mRNA 
      expression in the liver, with statistical differences (P＜0.05). Conclusion: 
      Hydrogen has a significant improvement effect on liver injury induced by HMD diet 
      in HHcy rats, possibly by enhancing the three metabolic pathways of Hcy to reduce 
      excessive Hcy in the body, thereby improving liver metabolic function and 
      symptoms of non-alcoholic fatty liver disease.
FAU - Chu, Wen-Bin
AU  - Chu WB
AD  - Institute of Environmental and Operational Medicine, Academy of Military Medical 
      Sciences, Academy of Military Sciences, Tianjin 300041, China.
FAU - Ding, Tian-Qi
AU  - Ding TQ
AD  - Institute of Environmental and Operational Medicine, Academy of Military Medical 
      Sciences, Academy of Military Sciences, Tianjin 300041, China.
FAU - Wen, Bo
AU  - Wen B
AD  - Institute of Environmental and Operational Medicine, Academy of Military Medical 
      Sciences, Academy of Military Sciences, Tianjin 300041, China.
FAU - Lu, Jun-Yu
AU  - Lu JY
AD  - Institute of Environmental and Operational Medicine, Academy of Military Medical 
      Sciences, Academy of Military Sciences, Tianjin 300041, China.
FAU - Fan, Rong
AU  - Fan R
AD  - Institute of Environmental and Operational Medicine, Academy of Military Medical 
      Sciences, Academy of Military Sciences, Tianjin 300041, China.
FAU - Chen, Xue-Wei
AU  - Chen XW
AD  - Institute of Environmental and Operational Medicine, Academy of Military Medical 
      Sciences, Academy of Military Sciences, Tianjin 300041, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - AE28F7PNPL (Methionine)
RN  - 73JWT2K6T3 (Racemethionine)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - 059QF0KO0R (Water)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Rats
MH  - Animals
MH  - Methionine
MH  - *Hyperhomocysteinemia
MH  - Rats, Wistar
MH  - Racemethionine
MH  - Diet
MH  - *Non-alcoholic Fatty Liver Disease
MH  - Homocysteine
MH  - Hydrogen
MH  - Water
MH  - RNA, Messenger
OTO - NOTNLM
OT  - folic acid
OT  - hydrogen rich water(HRW)
OT  - hyperhomocysteinemia (HHcy)
OT  - metabolic enzymes
OT  - non-alcoholic fatty liver disease (NAFLD)
OT  - rats
EDAT- 2023/06/13 01:14
MHDA- 2023/06/14 06:42
CRDT- 2023/06/12 22:03
PHST- 2023/06/14 06:42 [medline]
PHST- 2023/06/13 01:14 [pubmed]
PHST- 2023/06/12 22:03 [entrez]
AID - 10.12047/j.cjap.6382.2022.143 [doi]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022 Nov;38(6):787-792. doi: 
      10.12047/j.cjap.6382.2022.143.