PMID- 37310282 OWN - NLM STAT- MEDLINE DCOM- 20231219 LR - 20231219 IS - 1365-2931 (Electronic) IS - 1364-5706 (Linking) VI - 32 IP - 6 DP - 2023 Dec TI - EUS-guided gastroenterostomy for gastric outlet obstruction: a comprehensive meta-analysis. PG - 285-299 LID - 10.1080/13645706.2023.2221336 [doi] AB - OBJECTIVE: A comprehensive meta-analysis was performed to evaluate the efficacy and safety of endoscopic ultrasound-guided gastroenterostomy (EUS-GE) for benign and malignant gastric outlet obstruction (GOO). MATERIAL AND METHODS: PubMed, Embase, Web of Science and Cochrane Library were searched to identify relevant studies. The primary outcomes evaluated technical success, clinical success, and adverse events (AEs). RESULTS: Twenty‑six studies with 1493 patients were included in this meta-analysis. The pooled rates of technical success, clinical success, and overall AEs of EUS-GE were 94.0%, 89.9%, and 13.1%, respectively. Eight studies were included in the subgroup meta-analysis for comparative evaluation of EUS-GE and surgical gastroenterostomy (SGE), while seven studies were for EUS-GE and enteral stenting (ES). Compared with SGE, the pooled odds ratios (ORs) of technical success, clinical success, and overall AEs of EUS-GE were 0.17 (p = .003), 1.42 (p = .40), and 0.15 (p < .00001), respectively. When compared with ES, the above corresponding pooled ORs were 0.55 (p = .11), 2.64 (p < .0001), and 0.41 (p = .01), respectively. CONCLUSION: Although it is technically challenging, this largest meta-analysis indicates that EUS‑GE has comparable and high technical and clinical success rates and hence a very effective minimally invasive procedure for GOO. FAU - Li, Jia-Su AU - Li JS AD - Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. FAU - Lin, Kun AU - Lin K AD - Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. FAU - Tang, Jian AU - Tang J AD - Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Liu, Feng AU - Liu F AUID- ORCID: 0000-0002-5126-5389 AD - Digestive Endoscopy Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Fang, Jun AU - Fang J AUID- ORCID: 0009-0005-6702-0289 AD - Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review DEP - 20230613 PL - England TA - Minim Invasive Ther Allied Technol JT - Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy JID - 9612996 SB - IM MH - Humans MH - *Gastroenterostomy/adverse effects/methods MH - *Gastric Outlet Obstruction/etiology/surgery MH - Endosonography/methods MH - Stents MH - Retrospective Studies OTO - NOTNLM OT - EUS-guided gastroenterostomy OT - adverse events OT - enteral stenting OT - gastric outlet obstruction OT - surgical gastroenterostomy EDAT- 2023/06/13 13:12 MHDA- 2023/12/19 06:41 CRDT- 2023/06/13 10:14 PHST- 2023/12/19 06:41 [medline] PHST- 2023/06/13 13:12 [pubmed] PHST- 2023/06/13 10:14 [entrez] AID - 10.1080/13645706.2023.2221336 [doi] PST - ppublish SO - Minim Invasive Ther Allied Technol. 2023 Dec;32(6):285-299. doi: 10.1080/13645706.2023.2221336. Epub 2023 Jun 13.