PMID- 37311390
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 261
DP  - 2023 Aug
TI  - Multivariate response surface methodology assisted modified QuEChERS method for 
      the rapid determination of 39 pesticides and metabolites in medlar.
PG  - 115102
LID - S0147-6513(23)00606-1 [pii]
LID - 10.1016/j.ecoenv.2023.115102 [doi]
AB  - A modified QuEChERS method coupled with high performance liquid 
      chromatography-tandem mass spectrometry (HPLC-MS/MS) was established for residue 
      analysis of 39 pollutants (34 commonly used multi-class pesticides and 5 
      metabolites) in medlar matrices (fresh, dried, and medlar juice). Samples were 
      extracted using water with 0.1 % formic acid: acetonitrile (5: 10, v/v). The 
      phase-out salts and five different cleanup sorbents (including N-propyl 
      ethylenediamine (PSA), octadecyl silane bonded silica gel (C18), graphitized 
      carbon black (GCB), Carbon nanofiber (C-Fiber) and MWCNTs) were investigated to 
      improve the purification efficiency. The Box-Behnken Design (BBD) study was 
      employed for an optimal solution of the volume of extraction solvent, phase-out 
      salt, and the purification sorbents for the analytical method. The average 
      recoveries of the target analytes in the three medlar matrices ranged from 70 % 
      to 119 % with relative standard deviations (RSDs) of 1.0 %-19.9 %. Screening of 
      market samples (fresh and dried medlars) collected from the major producing 
      regions in China showed that 15 pesticides and metabolites were detected in the 
      samples at concentrations of 0.01-2.22 mg/kg, and none of which exceeded the 
      maximum residue limits (MRLs) set in China. The results showed that the risk of 
      food safety by consumption of medlar products caused by the use of pesticides was 
      low. The validated method could be used for rapid and accurate screening of 
      multi-class multi-pesticide residues in Medlar for food safety.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhuang, Ming
AU  - Zhuang M
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Science, China Agricultural University, Beijing 100193, China.
FAU - Yao, Wei
AU  - Yao W
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Science, China Agricultural University, Beijing 100193, China; Beijing 
      Vocational College of Agriculture, Beijing 102500, China.
FAU - Han, Lijun
AU  - Han L
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Science, China Agricultural University, Beijing 100193, China. Electronic 
      address: hlj2000@cau.edu.cn.
FAU - Bi, Yingying
AU  - Bi Y
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Science, China Agricultural University, Beijing 100193, China.
FAU - Qiao, Chengkui
AU  - Qiao C
AD  - Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, 
      Zhengzhou 450009, China.
FAU - Lv, Xinru
AU  - Lv X
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Science, China Agricultural University, Beijing 100193, China.
FAU - Cao, Mengyuan
AU  - Cao M
AD  - Innovation Center of Pesticide Research, Department of Applied Chemistry, College 
      of Science, China Agricultural University, Beijing 100193, China.
FAU - Xie, Hanzhong
AU  - Xie H
AD  - Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, 
      Zhengzhou 450009, China.
LA  - eng
PT  - Journal Article
DEP - 20230611
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Pesticides)
RN  - 0 (Pesticide Residues)
SB  - IM
MH  - *Pesticides/analysis
MH  - Tandem Mass Spectrometry/methods
MH  - *Pesticide Residues/analysis
MH  - Chromatography, High Pressure Liquid
MH  - Vegetables/chemistry
MH  - Solid Phase Extraction/methods
OTO - NOTNLM
OT  - Box-behnken design
OT  - Environmental contaminants
OT  - HPLC-MS/MS
OT  - Method optimization
OT  - Residue analysis
COIS- Declaration of Competing Interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Lijun Han reports financial support was provided by Beijing Natural 
      Science Foundation. Lijun Han reports financial support was provided by Tianjin 
      Municipal Natural Science Foundation. Lijun Han reports financial support was 
      provided by Hebei Provincial Natural Science Foundation.
EDAT- 2023/06/14 01:10
MHDA- 2023/06/19 13:08
CRDT- 2023/06/13 18:04
PHST- 2023/03/01 00:00 [received]
PHST- 2023/05/18 00:00 [revised]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/06/14 01:10 [pubmed]
PHST- 2023/06/13 18:04 [entrez]
AID - S0147-6513(23)00606-1 [pii]
AID - 10.1016/j.ecoenv.2023.115102 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Aug;261:115102. doi: 10.1016/j.ecoenv.2023.115102. 
      Epub 2023 Jun 11.