PMID- 37311392 OWN - NLM STAT- MEDLINE DCOM- 20230619 LR - 20230619 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 261 DP - 2023 Aug TI - Association between whole blood essential trace elements and cognitive function in older adults. PG - 115114 LID - S0147-6513(23)00618-8 [pii] LID - 10.1016/j.ecoenv.2023.115114 [doi] AB - BACKGROUND: Essential trace elements (ETEs) are essential nutrients for keeping the nervous system functioning. Associations between ETEs and cognitive function are still inconclusive and limited. OBJECTIVES: We aimed to investigate the individual and joint associations between ETEs and cognitive function among older adults. METHODS: A population (N = 2181) at an average age>/= 65 from Yiwu cohort in China was available for this study. Whole blood chromium (Cr), selenium (Se), manganese (Mn), and copper (Cu) concentrations were measured by inductively coupled plasma mass spectrometry (ICP-MS). Cognitive function was assessed using the Mini-Mental State Examination (MMSE), consisting of five specific cognitive domains: orientation, registry, attention and calculation, recall, and language and praxis. Linear regression, restricted cubic spline (RCS) analysis, and Bayesian kernel machine regression (BKMR) were used to analyze the individual and joint associations between ETEs and cognitive function. RESULTS: The association between Cr and MMSE score presented an inverted-U shape (Q3 versus Q1: beta = 0.774, 95 % CI: 0.297, 1.250; Q4 versus Q1: beta = 0.481, 95 % CI: 0.006, 0.956); and Cr was especially associated with the registry, recall, and language and praxis. Per IQR (36.32 mug/L) increase of Se was positively associated with the MMSE score (beta = 0.497, 95 % CI: 0.277, 0.717) and all five cognitive domains. The BKMR showed that the dose-response association between Se and cognitive function increased initially and then decreased with increasing Se concentration when fixed the other ETEs in median. ETEs mixture was positively associated with cognitive function, and Se (posterior inclusion probabilities, PIPs = 0.915) was the most important contributor within the ETEs mixture. CONCLUSIONS: The nonlinear association between Cr and cognitive function suggested further exploration of an appropriate concentration range for ETEs. A positive association between mixed ETEs and cognitive function is a reminder that their joint association should be considered. Further prospective studies or intervention studies are warranted to validate our findings in the future. CI - Copyright (c) 2023. Published by Elsevier Inc. FAU - Lin, Yao-Yao AU - Lin YY AD - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Meng, Lin AU - Meng L AD - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Guo, Fan-Jia AU - Guo FJ AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Zhang, Xin-Han AU - Zhang XH AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Yang, Dan-Dan AU - Yang DD AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Yao, Xue-Cheng AU - Yao XC AD - Department of Public Health, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, China. FAU - Jin, Ming-Juan AU - Jin MJ AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Wang, Jian-Bing AU - Wang JB AD - Department of Public Health, National Clinical Research Center for Child Health of Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. FAU - Tang, Meng-Ling AU - Tang ML AD - Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: tangml@zju.edu.cn. FAU - Chen, Kun AU - Chen K AD - Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address: ck@zju.edu.cn. LA - eng PT - Journal Article DEP - 20230611 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Trace Elements) RN - H6241UJ22B (Selenium) RN - 0R0008Q3JB (Chromium) SB - IM MH - Humans MH - Aged MH - *Trace Elements MH - Prospective Studies MH - Bayes Theorem MH - *Selenium MH - Chromium MH - Cognition OTO - NOTNLM OT - Cognitive function OT - Essential trace element OT - Joint association OT - Mixtures OT - Older adults COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/06/14 01:10 MHDA- 2023/06/19 13:08 CRDT- 2023/06/13 18:04 PHST- 2023/02/23 00:00 [received] PHST- 2023/05/09 00:00 [revised] PHST- 2023/06/05 00:00 [accepted] PHST- 2023/06/19 13:08 [medline] PHST- 2023/06/14 01:10 [pubmed] PHST- 2023/06/13 18:04 [entrez] AID - S0147-6513(23)00618-8 [pii] AID - 10.1016/j.ecoenv.2023.115114 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2023 Aug;261:115114. doi: 10.1016/j.ecoenv.2023.115114. Epub 2023 Jun 11.