PMID- 37313029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231031
IS  - 2008-126X (Print)
IS  - 2228-7442 (Electronic)
IS  - 2008-126X (Linking)
VI  - 13
IP  - 5
DP  - 2022 Sep-Oct
TI  - Effects of Memantine on the Spontaneous Firing Frequency of Hippocampal CA1 
      Pyramidal Neurons in Intact and Alzheimer Rat Model: An Electrophysiological 
      Study.
PG  - 661-674
LID - 10.32598/bcn.2021.1970.1 [doi]
AB  - INTRODUCTION: Memantine (MEM) is a noncompetitive N-methyl-D-aspartate receptor 
      (NMDAR) antagonist clinically used for the treatment of Alzheimer disease (AD) in 
      mild to severe conditions. The present study was conducted to investigate the 
      effects of memantine on the spontaneous firing frequency of CA1 pyramidal neurons 
      in rats caused by an electrical lesion of Nucleus Basalis Magnocellularis (NBM). 
      Then, this model of AD rats was compared with the intact adult male rats. 
      METHODS: In this study, adult male rats were divided into two groups. Group I 
      (lesion of NBM, n=53) includes the following subgroups: lesion+saline, 
      sham+saline, lesion+MEM 5 mg/kg, lesion+MEM 10 mg/kg, and lesion+MEM 20mg/kg. 
      Group II (intact, n=48) includes the following subgroups: intact+saline, 
      intact+MEM 3mg/kg, intact+MEM 5mg/kg, and intact+MEM 10mg/kg. Extracellular 
      single-unit recording (15 min baseline+105 min after MEM or saline) was performed 
      under urethane-anesthetized rats. RESULTS: The results showed that the mean 
      frequency of CA1 pyramidal neurons after saline in the lesion+saline (P<0.001) 
      group significantly decreases compared with the intact+saline and sham+saline 
      groups. In addition, after saline and memantine, the mean frequency of CA1 
      pyramidal neurons in the lesion+MEM 10 mg/kg (P<0.01) and lesion+MEM 20 mg/kg 
      (P<0.001) groups significantly increased compared with the lesion+saline group. 
      Also, the mean frequencies of CA1 pyramidal neurons in the intact+MEM 10 mg/kg 
      (P<0.001) group significantly decreased compared with the intact+saline group. 
      CONCLUSION: Results showed that memantine increases the electrical activity of 
      CA1 pyramidal neurons in a rat model of AD. Furthermore, in the intact adult male 
      rats, the low-dose memantine, contrary to high dose, does not decrease the 
      electrical activity of CA1 pyramidal neurons.
CI  - Copyright(c) 2022 Iranian Neuroscience Society.
FAU - Zamani, Nastaran
AU  - Zamani N
AUID- ORCID: 0000-0001-9293-190X
AD  - Department of Biology, School of Science, Payame Noor University, Tehran, Iran.
FAU - Moazedi, Ahmad Ali
AU  - Moazedi AA
AUID- ORCID: 0000-0003-1346-2426
AD  - Department of Biology, School of Science, Shahid Chamran University of Ahvaz, 
      Ahvaz, Iran.
AD  - Stem Cell and Transgenic Technology Research Center, Shahid Chamran University of 
      Ahvaz, Ahvaz, Iran.
FAU - Afarinesh Khaki, Mohamad Reza
AU  - Afarinesh Khaki MR
AUID- ORCID: 0000-0002-5122-9900
AD  - Kerman Cognitive Research Center, Kerman Neuroscience Research Center, Institute 
      of Neuropharmachology, Kerman University of Medical Sciences, Kerman, Iran.
FAU - Pourmehdi Boroujeni, Mehdi
AU  - Pourmehdi Boroujeni M
AUID- ORCID: 0000-0002-8996-744X
AD  - Department of Food Hygiene, School of Veterinary Medicine, Shahid Chamran 
      University of Ahvaz, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220901
PL  - Iran
TA  - Basic Clin Neurosci
JT  - Basic and clinical neuroscience
JID - 101575211
PMC - PMC10258597
OTO - NOTNLM
OT  - Acetylcholine
OT  - Alzheimer disease
OT  - Hippocampal neurons
OT  - Memantine
OT  - Single-unit recording
COIS- Conflict of interest The authors declared no conflict of interest.
EDAT- 2023/06/14 06:42
MHDA- 2023/06/14 06:43
PMCR- 2022/09/01
CRDT- 2023/06/14 03:51
PHST- 2019/08/05 00:00 [received]
PHST- 2020/02/05 00:00 [revised]
PHST- 2020/04/19 00:00 [accepted]
PHST- 2023/06/14 06:43 [medline]
PHST- 2023/06/14 06:42 [pubmed]
PHST- 2023/06/14 03:51 [entrez]
PHST- 2022/09/01 00:00 [pmc-release]
AID - BCN-13-661 [pii]
AID - 10.32598/bcn.2021.1970.1 [doi]
PST - ppublish
SO  - Basic Clin Neurosci. 2022 Sep-Oct;13(5):661-674. doi: 10.32598/bcn.2021.1970.1. 
      Epub 2022 Sep 1.