PMID- 37313333
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230615
IS  - 0972-7531 (Print)
IS  - 0976-3260 (Electronic)
IS  - 0972-7531 (Linking)
VI  - 30
IP  - 1
DP  - 2023 Jan
TI  - Homocysteine, Vitamins B6, B12, and Folate and the Risk of Ischemic and 
      Hemorrhagic Stroke: A Case-control Study from Northeast India.
PG  - 33-39
LID - 10.1177/09727531221124425 [doi]
AB  - BACKGROUND: Stroke is a major leading global health complication. Identification 
      and management of risk factors associated with stroke can help in prior 
      detection, prevention, and improvement in patient care. PURPOSE: To investigate 
      the prevalence of hyperhomocysteinemia (HHcy) and Vitamins B6, B12, and folate 
      deficiency in stroke patients and also to assess other risk factors associated 
      with ischemic and hemorrhagic stroke. METHODS: Detail history of all the subjects 
      in the study including history of hypertension, anemia, fasting glucose, carotid 
      artery thickness, smoking, alcohol, and dietary intake was recorded. Standard 
      assays for homocysteine (Hcy), Vitamins B6, B12, and folate estimation were done. 
      Lipid and renal profile tests were also performed. The prevalence and odds of 
      having HHcy, Vitamins B6, B12, and folate deficiency, and other risk factors in 
      ischemic and hemorrhagic stroke patients were evaluated. Student's t-tests and 
      chi-square tests were done for statistical validation of the data. RESULTS: 
      Prevalence of HHcy and Vitamins B6, B12, and folate deficiency was not observed 
      in ischemic cases. HHcy and folate deficiency was found to be prevalent in 
      hemorrhagic stroke patients. The odds that a person with HHcy and folate 
      deficiency has hemorrhagic stroke was found to be significantly high. CONCLUSION: 
      In our study, high Hcy and low folate levels emerged as risk factors for 
      hemorrhagic stroke.
CI  - (c) The Author(s) 2022.
FAU - Ghose, Manash
AU  - Ghose M
AD  - Department of Neurology, GNRC Hospitals, Dispur, Guwahati, Assam, India.
FAU - Das, Madhumita
AU  - Das M
AD  - Department of Biochemistry, GNRC Medical, North Guwahati, Assam, India.
FAU - Das, Rupjyoti
AU  - Das R
AD  - Department of Neurology, GNRC Hospitals, Dispur, Guwahati, Assam, India.
FAU - Barua, Amit Ranjan
AU  - Barua AR
AD  - Department of Neurology, GNRC Medical, North Guwahati, Assam, India.
FAU - Deka, Prasenjit
AU  - Deka P
AD  - Department of Neurology, GNRC Hospitals, Six Mile, Guwahati, Assam, India.
FAU - Barman, Aparajita
AU  - Barman A
AD  - Department of Neurology, GNRC Hospitals, Dispur, Guwahati, Assam, India.
FAU - Lahan, Vivekananda
AU  - Lahan V
AD  - Department of Neurology, GNRC Hospitals, Six Mile, Guwahati, Assam, India.
FAU - Choudhury, Dhruba Jyoti
AU  - Choudhury DJ
AD  - Department of Neurology, GNRC Medical, North Guwahati, Assam, India.
FAU - Sharma, Jai Prakash
AU  - Sharma JP
AD  - Department of Neurology, GNRC Medical, North Guwahati, Assam, India.
FAU - Mathur, Manik
AU  - Mathur M
AD  - Department of Neurology, GNRC Hospitals, Dispur, Guwahati, Assam, India.
FAU - Borah, Nomal Chandra
AU  - Borah NC
AD  - Department of Neurology, GNRC Hospitals, Dispur, Guwahati, Assam, India.
FAU - Choudhury, Nupur
AU  - Choudhury N
AD  - Department of Research and Analytics, GNRC Hospitals, Dispur, Assam, India.
FAU - Barman, Ananya
AU  - Barman A
AUID- ORCID: 0000-0003-1533-2174
AD  - Department of Research and Analytics, GNRC Hospitals, Dispur, Assam, India.
LA  - eng
PT  - Journal Article
DEP - 20221003
PL  - United States
TA  - Ann Neurosci
JT  - Annals of neurosciences
JID - 101523367
PMC - PMC10259151
OTO - NOTNLM
OT  - Case-control study
OT  - folate
OT  - hemorrhagic stroke
OT  - homocysteine
OT  - ischemic stroke
COIS- The authors declare that there is no conflict of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/06/14 06:42
MHDA- 2023/06/14 06:43
PMCR- 2023/01/01
CRDT- 2023/06/14 03:55
PHST- 2022/06/09 00:00 [received]
PHST- 2022/08/18 00:00 [accepted]
PHST- 2023/06/14 06:43 [medline]
PHST- 2023/06/14 06:42 [pubmed]
PHST- 2023/06/14 03:55 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.1177_09727531221124425 [pii]
AID - 10.1177/09727531221124425 [doi]
PST - ppublish
SO  - Ann Neurosci. 2023 Jan;30(1):33-39. doi: 10.1177/09727531221124425. Epub 2022 Oct 
      3.