PMID- 37313414
OWN - NLM
STAT- MEDLINE
DCOM- 20230615
LR  - 20230615
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - HLA allele and haplotype frequencies of registered stem cell donors in Chile.
PG  - 1175135
LID - 10.3389/fimmu.2023.1175135 [doi]
LID - 1175135
AB  - Patients in need of hematopoietic stem cell transplantation often rely on 
      unrelated stem cell donors matched in certain human leukocyte antigen (HLA) 
      genes. Donor search is complicated by the extensive allelic variability of the 
      HLA system. Therefore, large registries of potential donors are maintained in 
      many countries worldwide. Population-specific HLA characteristics determine the 
      registry benefits for patients and also the need for further regional donor 
      recruitment. In this work, we analyzed HLA allele and haplotype frequencies of 
      donors of DKMS Chile, the first Chilean donor registry, with self-assessed 
      "non-Indigenous" (n=92,788) and "Mapuche" (n=1,993) ancestry. We identified HLA 
      alleles that were distinctly more abundant in the Chilean subpopulations than in 
      worldwide reference populations, four of them particularly characteristic for the 
      Mapuche subpopulation, namely B*39:09g, B*35:09, DRB1*04:07g, and DRB1*16:02g. 
      Both population subsamples carried haplotypes of both Native American and 
      European origin at high frequencies, reflecting Chile's complex history of 
      admixture and immigration. Matching probability analysis revealed limited 
      benefits for Chilean patients (both non-Indigenous and Mapuche) from donor 
      registries of non-Chilean donors, thus indicating a need for ongoing significant 
      donor recruitment efforts in Chile.
CI  - Copyright (c) 2023 Solloch, Giani, Pattillo Garnham, Sauter, Bernas, Lange, 
      Barriga, Fernandez-Vina and Schmidt.
FAU - Solloch, Ute V
AU  - Solloch UV
AD  - DKMS, Tubingen, Germany.
FAU - Giani, Anette S
AU  - Giani AS
AD  - Fundacion de Beneficencia Publica DKMS, Santiago, Chile.
FAU - Pattillo Garnham, Maria Ignacia
AU  - Pattillo Garnham MI
AD  - Fundacion de Beneficencia Publica DKMS, Santiago, Chile.
FAU - Sauter, Jurgen
AU  - Sauter J
AD  - DKMS, Tubingen, Germany.
FAU - Bernas, Stefanie N
AU  - Bernas SN
AD  - DKMS, Tubingen, Germany.
FAU - Lange, Vinzenz
AU  - Lange V
AD  - DKMS Life Science Lab gGmbH, Dresden, Germany.
FAU - Barriga, Francisco
AU  - Barriga F
AD  - Fundacion de Beneficencia Publica DKMS, Santiago, Chile.
FAU - Fernandez-Vina, Marcelo A
AU  - Fernandez-Vina MA
AD  - Department of Pathology, Stanford University, Stanford, CA, United States.
FAU - Schmidt, Alexander H
AU  - Schmidt AH
AD  - DKMS, Tubingen, Germany.
AD  - DKMS Life Science Lab gGmbH, Dresden, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230529
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Humans
MH  - Chile
MH  - Alleles
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation
PMC - PMC10258311
OTO - NOTNLM
OT  - Chile
OT  - HLA
OT  - HSCT
OT  - donor registry
OT  - haplotype frequency
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/06/14 06:42
MHDA- 2023/06/15 06:42
PMCR- 2023/01/01
CRDT- 2023/06/14 03:57
PHST- 2023/02/27 00:00 [received]
PHST- 2023/05/15 00:00 [accepted]
PHST- 2023/06/15 06:42 [medline]
PHST- 2023/06/14 06:42 [pubmed]
PHST- 2023/06/14 03:57 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1175135 [doi]
PST - epublish
SO  - Front Immunol. 2023 May 29;14:1175135. doi: 10.3389/fimmu.2023.1175135. 
      eCollection 2023.