PMID- 37313582
OWN - NLM
STAT- MEDLINE
DCOM- 20230725
LR  - 20230730
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 101
IP  - 9
DP  - 2023 Sep
TI  - Transcranial direct current stimulation alleviates nociceptive behavior in male 
      rats with neuropathic pain by regulating oxidative stress and reducing 
      neuroinflammation.
PG  - 1457-1470
LID - 10.1002/jnr.25204 [doi]
AB  - Transcranial direct curent stimulation (tDCS) and trans-spinal direct current 
      stimulation (tsDCS) are promising therapies for pain that can alter the 
      excitability of neuronal activity in cerebral cortex. The aim of the study is to 
      investigate the therapeutic effects of direct current stimulation (DCS) over the 
      spinal cord and cerebral cortex on oxidative stress and neuroinflammation in rats 
      with chronic constriction injury (CCI). Male Wistar rats were randomly divided 
      into four experimental groups: Sham, CCI, CCI + tDCS and CCI + tsDCS. The 
      neuropathic pain model was induced by using the CCI model. Rats with neuropathy 
      were treated with cathodal tDCS and tsDCS stimulations consisting of 0.5 mA for 
      30 min a day for 7 days from day 8 onwards. Locomotor activity was measured by 
      open-field test and nociceptive behavior was assessed by hot-plate, tail-flick 
      and Randall-Selitto tests. Following the behavioral experiments, total oxidant 
      capacity (TOC), total antioxidant capacity (TAC) and proinflammatory cytokine 
      levels were evaluated in spinal cord and cerebral cortex tissues. The CCI model 
      induced significant mechanical and thermal hyperalgesia. Nociceptive behaviors in 
      rats with CCI were reversed by DCS treatment. Higher TOC and lower TAC levels 
      were detected in the spinal cord and cerebral cortex tissues of the CCI rats 
      compared to the control. tsDCS treatment amended oxidant/antioxidant status. 
      Moreover, tsDCS modulated the central levels of Tumor necrosis factor-alpha (TNF-alpha), 
      interleukin 1-beta (IL-1beta), IL-6 and IL-18. tsDCS stimulation showed better 
      therapeutic effect on neuropathic pain by regulating oxidant/antioxidant levels 
      and reducing neuroinflammation. DCS, especially at spinal level, may be a 
      promising therapeutic strategy that can be used alone or in combination with 
      other effective treatments for alleviating neuropathic pain.
CI  - (c) 2023 The Authors. Journal of Neuroscience Research published by Wiley 
      Periodicals LLC.
FAU - Akcay, Guven
AU  - Akcay G
AD  - Faculty of Medicine, Department of Biophysics, Hitit University, Corum, Turkey.
FAU - Nemutlu Samur, Dilara
AU  - Nemutlu Samur D
AD  - Faculty of Medicine, Department of Pharmacology, Alanya Alaaddin Keykubat 
      University, Antalya, Turkey.
FAU - Derin, Narin
AU  - Derin N
AD  - Faculty of Medicine, Department of Biophysics, Akdeniz University, Antalya, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230614
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Antioxidants)
RN  - 0 (Oxidants)
SB  - IM
MH  - Rats
MH  - Male
MH  - Animals
MH  - *Transcranial Direct Current Stimulation
MH  - Rats, Wistar
MH  - Antioxidants/therapeutic use
MH  - Neuroinflammatory Diseases
MH  - Nociception
MH  - Sciatic Nerve
MH  - *Neuralgia/therapy/pathology
MH  - Hyperalgesia/drug therapy
MH  - Spinal Cord/pathology
MH  - Oxidative Stress
MH  - Oxidants/pharmacology/therapeutic use
OTO - NOTNLM
OT  - chronic constriction injury
OT  - neuroinflammation
OT  - neuropathic pain
OT  - tDCS
EDAT- 2023/06/14 06:42
MHDA- 2023/07/25 06:42
CRDT- 2023/06/14 04:01
PHST- 2023/03/30 00:00 [revised]
PHST- 2023/01/22 00:00 [received]
PHST- 2023/05/03 00:00 [accepted]
PHST- 2023/07/25 06:42 [medline]
PHST- 2023/06/14 06:42 [pubmed]
PHST- 2023/06/14 04:01 [entrez]
AID - 10.1002/jnr.25204 [doi]
PST - ppublish
SO  - J Neurosci Res. 2023 Sep;101(9):1457-1470. doi: 10.1002/jnr.25204. Epub 2023 Jun 
      14.