PMID- 37313667
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230616
IS  - 2586-6060 (Electronic)
IS  - 2586-6052 (Print)
IS  - 2586-6052 (Linking)
VI  - 38
IP  - 2
DP  - 2023 May
TI  - Percent fluid overload for prediction of fluid de-escalation in critically ill 
      patients in Saudi Arabia: a prospective observational study.
PG  - 209-216
LID - 10.4266/acc.2022.01550 [doi]
AB  - BACKGROUND: Percent fluid overload greater than 5% is associated with increased 
      mortality. The appropriate time for fluid deresuscitation depends on the 
      patient's radiological and clinical findings. This study aimed to assess the 
      applicability of percent fluid overload calculations for evaluating the need for 
      fluid deresuscitation in critically ill patients. METHODS: This was a 
      single-center, prospective, observational study of critically ill adult patients 
      requiring intravenous fluid administration. The study's primary outcome was 
      median percent fluid accumulation on the day of fluid deresuscitation or 
      intensive care unit (ICU) discharge, whichever came first. RESULTS: A total of 
      388 patients was screened between August 1, 2021, and April 30, 2022. Of these, 
      100 with a mean age of 59.8+/-16.2 years were included for analysis. The mean Acute 
      Physiology and Chronic Health Evaluation (APACHE) II score was 15.4+/-8.0. 
      Sixty-one patients (61.0%) required fluid deresuscitation during their ICU stay, 
      while 39 (39.0%) did not. Median percent fluid accumulation on the day of 
      deresuscitation or ICU discharge was 4.5% (interquartile range [IQR], 1.7%-9.1%) 
      and 5.2% (IQR, 2.9%-7.7%) in patients requiring deresuscitation and those who did 
      not, respectively. Hospital mortality occurred in 25 (40.9%) of patients with 
      deresuscitation and six (15.3%) patients who did not require it (P=0.007). 
      CONCLUSIONS: The percent fluid accumulation on the day of fluid deresuscitation 
      or ICU discharge was not statistically different between patients who required 
      fluid deresuscitation and those who did not. A larger sample size is needed to 
      confirm these findings.
FAU - Alharbi, Reham A
AU  - Alharbi RA
AD  - Division of Pharmaceutical Care, King Faisal Specialist Hospital and Research 
      Center, Jeddah, Saudi Arabia.
FAU - Aldardeer, Namareq F
AU  - Aldardeer NF
AD  - Division of Pharmaceutical Care, King Faisal Specialist Hospital and Research 
      Center, Jeddah, Saudi Arabia.
FAU - Heaphy, Emily L G
AU  - Heaphy ELG
AD  - Department of Research, King Faisal Specialist Hospital and Research Center, 
      Jeddah, Saudi Arabia.
FAU - Alabbasi, Ahmad H
AU  - Alabbasi AH
AD  - Nahdi Medical Company, Medina, Saudi Arabia.
FAU - Albuqami, Amjad M
AU  - Albuqami AM
AD  - United Pharmacy, Jeddah, Saudi Arabia.
FAU - Hawa, Hassan
AU  - Hawa H
AD  - Joint CCT in Acute and Intensive Care Medicine (UK), Department of Critical Care 
      Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi 
      Arabia.
LA  - eng
PT  - Journal Article
DEP - 20230516
PL  - Korea (South)
TA  - Acute Crit Care
JT  - Acute and critical care
JID - 101726905
PMC - PMC10265412
OTO - NOTNLM
OT  - critical care
OT  - de-escalation
OT  - fluid overload
OT  - prospective
COIS- CONFLICT OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/06/14 06:42
MHDA- 2023/06/14 06:43
PMCR- 2023/05/01
CRDT- 2023/06/14 04:35
PHST- 2022/12/16 00:00 [received]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/06/14 06:43 [medline]
PHST- 2023/06/14 06:42 [pubmed]
PHST- 2023/06/14 04:35 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - acc.2022.01550 [pii]
AID - acc-2022-01550 [pii]
AID - 10.4266/acc.2022.01550 [doi]
PST - ppublish
SO  - Acute Crit Care. 2023 May;38(2):209-216. doi: 10.4266/acc.2022.01550. Epub 2023 
      May 16.