PMID- 37313732
OWN - NLM
STAT- MEDLINE
DCOM- 20230803
LR  - 20230803
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 11
IP  - 30
DP  - 2023 Aug 2
TI  - Nanocellulose-based hydrogels for drug delivery.
PG  - 7004-7023
LID - 10.1039/d3tb00478c [doi]
AB  - Hydrogels, as a class of three-dimensional (3D) polymer networks, are important 
      candidates for drug delivery owing to their high porosity and hydrophilicity. 
      Generally, clinical applications put forward various requirements for drug 
      delivery systems (DDSs), such as low toxic side effects, high biocompatibility, 
      targeting, controllable release, and high drug loading. In recent years, 
      nanocellulose, including cellulose nanocrystals (CNCs) and cellulose nanofibrils 
      (CNFs), has emerged as a promising material for hydrogel-based DDSs. This is due 
      to its high surface area, abundant surface hydroxyl groups that can be easily 
      chemically modified for multifunctionalization, natural origin leading to high 
      biocompatibility and degradability, etc. This review provides a comprehensive 
      overview of the preparation methods for hydrogels based on CNCs/CNFs for use in 
      drug delivery systems, including physical crosslinking and chemical crosslinking. 
      Additionally, various carrier forms such as hydrogel particles, hydrogel films, 
      injectable hydrogels, and sprayable hydrogels are discussed. Key drug delivery 
      parameters including loading and release efficiency as well as responses to 
      different stimuli are also examined in detail. Finally, in view of the 
      subdivision of drug delivery, the opportunities and challenges of nano cellulose 
      based hydrogels were proposed from the perspective of application, and the 
      potential research directions were pointed out.
FAU - Ai, Yusen
AU  - Ai Y
AD  - State Key Laboratory of Chemical Engineering, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, P. R. China.
FAU - Lin, Zhongxin
AU  - Lin Z
AD  - State Key Laboratory of Chemical Engineering, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, P. R. China.
FAU - Zhao, Wenqi
AU  - Zhao W
AD  - Tianjin Medical University General Hospital, Tianjin 300052, P. R. China. 
      zxwqdcdy@126.com.
FAU - Cui, Mei
AU  - Cui M
AUID- ORCID: 0000-0003-2304-3903
AD  - State Key Laboratory of Chemical Engineering, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, P. R. China.
FAU - Qi, Wei
AU  - Qi W
AUID- ORCID: 0000-0002-7378-1392
AD  - State Key Laboratory of Chemical Engineering, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, P. R. China.
FAU - Huang, Renliang
AU  - Huang R
AUID- ORCID: 0000-0003-0797-3473
AD  - Zhejiang Institute of Tianjin University, Ningbo, Zhejiang, 315201, P. R. China.
AD  - School of Marine Science and Technology, Tianjin University, Tianjin 300072, P. 
      R. China. surx@tju.edu.cn.
FAU - Su, Rongxin
AU  - Su R
AUID- ORCID: 0000-0001-9778-9113
AD  - State Key Laboratory of Chemical Engineering, School of Chemical Engineering and 
      Technology, Tianjin University, Tianjin 300072, P. R. China.
AD  - Zhejiang Institute of Tianjin University, Ningbo, Zhejiang, 315201, P. R. China.
AD  - School of Marine Science and Technology, Tianjin University, Tianjin 300072, P. 
      R. China. surx@tju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230802
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Hydrogels)
RN  - 9004-34-6 (Cellulose)
RN  - 0 (Polymers)
SB  - IM
MH  - *Hydrogels/chemistry
MH  - Drug Delivery Systems/methods
MH  - Cellulose/chemistry
MH  - Polymers
MH  - *Nanoparticles/chemistry
EDAT- 2023/06/14 06:42
MHDA- 2023/08/03 06:43
CRDT- 2023/06/14 05:26
PHST- 2023/08/03 06:43 [medline]
PHST- 2023/06/14 06:42 [pubmed]
PHST- 2023/06/14 05:26 [entrez]
AID - 10.1039/d3tb00478c [doi]
PST - epublish
SO  - J Mater Chem B. 2023 Aug 2;11(30):7004-7023. doi: 10.1039/d3tb00478c.