PMID- 37316589 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230616 IS - 1869-4101 (Print) IS - 1869-4101 (Electronic) IS - 1869-4101 (Linking) VI - 14 IP - 1 DP - 2023 Jun 14 TI - Radiomics analysis of contrast-enhanced computed tomography in predicting the International Neuroblastoma Pathology Classification in neuroblastoma. PG - 106 LID - 10.1186/s13244-023-01418-5 [doi] LID - 106 AB - PURPOSE: To predict the International Neuroblastoma Pathology Classification (INPC) in neuroblastoma using a computed tomography (CT)-based radiomics approach. METHODS: We enrolled 297 patients with neuroblastoma retrospectively and divided them into a training group (n = 208) and a testing group (n = 89). To balance the classes in the training group, a Synthetic Minority Over-sampling Technique was applied. A logistic regression radiomics model based on the radiomics features after dimensionality reduction was then constructed and validated in both the training and testing groups. To evaluate the diagnostic performance of the radiomics model, the receiver operating characteristic curve and calibration curve were utilized. Moreover, the decision curve analysis to assess the net benefits of the radiomics model at different high-risk thresholds was employed. RESULTS: Seventeen radiomics features were used to construct radiomics model. In the training group, radiomics model achieved an area under the curve (AUC), accuracy, sensitivity, and specificity of 0.851 (95% confidence interval (CI) 0.805-0.897), 0.770, 0.694, and 0.847, respectively. In the testing group, radiomics model achieved an AUC, accuracy, sensitivity, and specificity of 0.816 (95% CI 0.725-0.906), 0.787, 0.793, and 0.778, respectively. The calibration curve indicated that the radiomics model was well fitted in both the training and testing groups (p > 0.05). Decision curve analysis further confirmed that the radiomics model performed well at different high-risk thresholds. CONCLUSION: Radiomics analysis of contrast-enhanced CT demonstrates favorable diagnostic capabilities in distinguishing the INPC subgroups of neuroblastoma. CRITICAL RELEVANCE STATEMENT: Radiomics features of contrast-enhanced CT images correlate with the International Neuroblastoma Pathology Classification (INPC) of neuroblastoma. CI - (c) 2023. The Author(s). FAU - Wang, Haoru AU - Wang H AD - Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. FAU - Xie, Mingye AU - Xie M AD - Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. FAU - Chen, Xin AU - Chen X AD - Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. FAU - Zhu, Jin AU - Zhu J AD - Department of Pathology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. FAU - Zhang, Li AU - Zhang L AD - Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. FAU - Ding, Hao AU - Ding H AD - Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. FAU - Pan, Zhengxia AU - Pan Z AD - Department of Cardiothoracic Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. panzhengxia005@sina.com. FAU - He, Ling AU - He L AD - Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Road 2, Yuzhong District, Chongqing, 400014, China. doctorheling@yeah.net. LA - eng GR - 20200155/Basic Research and Frontier Exploration Project (Yuzhong District, Chongqing, China)/ PT - Journal Article DEP - 20230614 PL - Germany TA - Insights Imaging JT - Insights into imaging JID - 101532453 PMC - PMC10267098 OTO - NOTNLM OT - Computed tomography OT - Neuroblastoma OT - Pathology OT - Radiomics COIS- The authors declare that they have no competing interests. EDAT- 2023/06/15 01:08 MHDA- 2023/06/15 01:09 PMCR- 2023/06/14 CRDT- 2023/06/14 23:22 PHST- 2022/12/06 00:00 [received] PHST- 2023/03/30 00:00 [accepted] PHST- 2023/06/15 01:09 [medline] PHST- 2023/06/15 01:08 [pubmed] PHST- 2023/06/14 23:22 [entrez] PHST- 2023/06/14 00:00 [pmc-release] AID - 10.1186/s13244-023-01418-5 [pii] AID - 1418 [pii] AID - 10.1186/s13244-023-01418-5 [doi] PST - epublish SO - Insights Imaging. 2023 Jun 14;14(1):106. doi: 10.1186/s13244-023-01418-5.