PMID- 37317905
OWN - NLM
STAT- Publisher
LR  - 20230615
IS  - 1875-6182 (Electronic)
IS  - 1871-5257 (Linking)
DP  - 2023 Jun 14
TI  - Philadelphia Chromosome Positive Chronic Myelogenous Leukemia Blastic Crisis in A 
      Patient with Unusual Primary Myelofibrosis Characteristics; A Case Report.
LID - 10.2174/1871525721666230614110621 [doi]
AB  - INTRODUCTION: Myeloproliferative neoplasms (MPNs) are divided into BCR-ABL 
      positive Chronic myeloid leukemia (CML) and BCR-ABL negative MPNs including 
      Polycythemia vera (PV), Essential Thrombocythemia (ET) and Primary myelofibrosis 
      (PMF). Evaluation of the Philadelphia chromosome in MPNs is a diagnostic 
      requirement for classic CML. CASE REPORT: In 2020, a 37-year-old woman with 
      negative cytogenetic testing for Janus kinase2 (JAK2), Calreticulin (CALR), 
      myeloproliferative leukemia virus oncogene (MPL), and positive for BCR-ABL1 
      mutation with reticular fibrosis in bone marrow was diagnosed as CML. Some years 
      ago, the patient had been diagnosed with PMF with evidence of histiocytic 
      necrotizing lymphadenitis or Kikuchi-Fujimoto disease (KFD). The BCR-ABL fusion 
      gene was initially evaluated which was negative. Then, Cutaneous squamous cell 
      carcinoma (cSCC) was confirmed by Dermatopathologist with palpable splenomegaly 
      and high white blood cell (WBC) count with basophilia. Finally, BCR-ABL was 
      detected positive by the fluorescence in situ hybridization (FISH) and 
      quantitative real-time polymerase chain reaction (qRT-PCR). In fact, the 
      co-occurrence of PMF with CML was identified. CONCLUSION: This case study 
      highlighted the importance of some cytogenetic methods in the detection and 
      classification of MPNs. It is recommended that physicians pay more attention to 
      it and be aware of the planning treatment.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Razmara Lak, Elahe
AU  - Razmara Lak E
AD  - Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
FAU - Sharifzadeh, Sedigheh
AU  - Sharifzadeh S
AD  - Diagnostic Laboratory Sciences and Technology Research Center, School of 
      Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Ramzi, Mani
AU  - Ramzi M
AD  - Hematology research center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Mokhtari, Maral
AU  - Mokhtari M
AD  - Department of Pathology, Shahid Faghihi Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Asadpouri, Reza
AU  - Asadpouri R
AD  - Department of Medical Parasitology, Faculty of Medicine, Ahvaz Jundishapur 
      University of Medical Sciences, Iran.
FAU - Abedi, Elham
AU  - Abedi E
AD  - Hematology research center, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Tamaddon, Gholamhossein
AU  - Tamaddon G
AD  - Diagnostic Laboratory Sciences and Technology Research Center, School of 
      Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
LA  - eng
PT  - Case Reports
DEP - 20230614
PL  - Netherlands
TA  - Cardiovasc Hematol Agents Med Chem
JT  - Cardiovascular & hematological agents in medicinal chemistry
JID - 101266881
SB  - IM
OTO - NOTNLM
OT  - BCR-ABL positive Chronic myeloid leukemia
OT  - Cutaneous squamous cell carcinoma
OT  - Myeloproliferative neoplasms
OT  - Primary myelofibrosis
OT  - fluorescence in situ hybridization
OT  - histiocytic necrotizing lymphadenitis
EDAT- 2023/06/15 06:42
MHDA- 2023/06/15 06:42
CRDT- 2023/06/15 05:34
PHST- 2022/11/12 00:00 [received]
PHST- 2023/02/22 00:00 [revised]
PHST- 2023/03/29 00:00 [accepted]
PHST- 2023/06/15 06:42 [medline]
PHST- 2023/06/15 06:42 [pubmed]
PHST- 2023/06/15 05:34 [entrez]
AID - CHAMC-EPUB-132515 [pii]
AID - 10.2174/1871525721666230614110621 [doi]
PST - aheadofprint
SO  - Cardiovasc Hematol Agents Med Chem. 2023 Jun 14. doi: 
      10.2174/1871525721666230614110621.