PMID- 37319368
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 12
DP  - 2023 Nov 17
TI  - Type 2 Diabetes Family History as a Significant Index on the Clinical 
      Heterogeneity Differentiation in Type 1 Diabetes.
PG  - e1633-e1641
LID - 10.1210/clinem/dgad363 [doi]
AB  - CONTEXT: Family history of type 2 diabetes (T2D) is an important but neglected 
      parameter; however, its role in identifying the heterogeneity and subtypes of 
      type 1 diabetes (T1D) remains unclear. OBJECTIVE: We investigated the effect of 
      family history of T2D on the clinical phenotype of T1D patients and evaluated its 
      value in T1D classification. METHODS: A total of 1410 T1D patients were enrolled 
      in this prospective study. Information on family history of T2D in first-degree 
      relatives (FDRs) was collected by research nurses using a semi-structured 
      questionnaire as previously described. The effect of family history of T2D on 
      clinical characteristics was evaluated in overall and subgroups of T1D patients 
      stratified by islet autoantibodies, onset age, and human leukocyte antigen (HLA) 
      genotype. Cluster analysis was performed to identify family history of 
      T2D-related subgroups. RESULTS: A total of 10% (141/1410) of patients had at 
      least 1 FDR diagnosed with T2D. A milder phenotype associated with family history 
      of T2D was present in overall T1D patients, including older onset age (P < .001), 
      higher body mass index (P < .001), higher fasting and postprandial C-peptide 
      levels (all P < .01), lower positive rates of all islet autoantibodies, and 
      susceptible HLA genotypes (all P < .05). Clinical heterogeneity associated with 
      family history of T2D in the T1D subgroup stratified by autoimmunity, age of 
      onset, and HLA genotypes was consistent. Using family history of T2D as a cluster 
      variable, T1D patients were divided into 5 clusters, and patients in the T2D 
      family history cluster displayed a milder phenotype than others. CONCLUSION: 
      Family history of T2D should be considered as an important indicator for precise 
      subclassification of T1D patients based on clinical heterogeneity.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Wang, Qianrong
AU  - Wang Q
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Xie, Yuting
AU  - Xie Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Xia, Ying
AU  - Xia Y
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Xie, Zhiguo
AU  - Xie Z
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Huang, Gan
AU  - Huang G
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Fan, Li
AU  - Fan L
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Zhou, Zhiguang
AU  - Zhou Z
AUID- ORCID: 0000-0002-0374-1838
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
FAU - Li, Xia
AU  - Li X
AUID- ORCID: 0000-0001-8665-7983
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology (Central South University), Ministry of Education, and 
      Department of Metabolism and Endocrinology, The Second Xiangya Hospital of 
      Central South University, Changsha, Hunan 410011, China.
LA  - eng
GR  - 2022YFC2010102/National Key R&D Program of China/
GR  - 2020RC4044/Science and Technology Innovation Program of Hunan Province/
GR  - 82070812/National Natural Science Foundation of China/
GR  - 2021JC0003/Natural Science Foundation of Hunan Province/
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 1/diagnosis
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - Prospective Studies
MH  - Autoantibodies
MH  - Autoimmunity
MH  - HLA Antigens
MH  - Histocompatibility Antigens Class II
OTO - NOTNLM
OT  - cluster analysis
OT  - family history
OT  - heterogeneity
OT  - type 1 diabetes
OT  - type 2 diabetes
EDAT- 2023/06/15 19:14
MHDA- 2023/11/27 12:44
CRDT- 2023/06/15 15:37
PHST- 2023/03/11 00:00 [received]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/06/15 19:14 [pubmed]
PHST- 2023/06/15 15:37 [entrez]
AID - 7199084 [pii]
AID - 10.1210/clinem/dgad363 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Nov 17;108(12):e1633-e1641. doi: 
      10.1210/clinem/dgad363.