PMID- 37319430
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20240120
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 12
DP  - 2023 Nov 17
TI  - Childhood Obesity, Diabetes. and Cardiovascular Disease Risk.
PG  - 3051-3066
LID - 10.1210/clinem/dgad361 [doi]
AB  - This mini-review aims to briefly summarize the pathophysiology of childhood 
      obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk 
      in children and adolescents. Recent data on efficacy of lifestyle interventions, 
      medications, and metabolic surgery for obesity, T2DM, and CVD risk factors are 
      also reviewed. We conducted a PubMed search of English-language original and 
      review articles relevant to childhood obesity, T2DM, and CVD risk factors, and 
      biomarkers in children with an emphasis on recent publications. Childhood obesity 
      arises from an intricate interaction between genetic, physiologic, environmental, 
      and socioeconomic factors. The rise in the prevalence of childhood obesity is 
      associated with the development of comorbidities including T2DM and CVD at an 
      early age. A multipronged approach is central to the detection, monitoring, and 
      management of childhood obesity and associated adverse metabolic consequences.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Salama, Mostafa
AU  - Salama M
AD  - Division of Pediatric Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 
      55905, USA.
AD  - Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Balagopal, Babu
AU  - Balagopal B
AD  - Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
AD  - Department of Biomedical Research, Nemours Children's Health System, 
      Jacksonville, FL 32207, USA.
FAU - Fennoy, Ilene
AU  - Fennoy I
AD  - Division of Pediatric Endocrinology, Diabetes and Metabolism, Columbia 
      University, New York, NY 10032, USA.
FAU - Kumar, Seema
AU  - Kumar S
AUID- ORCID: 0000-0001-8004-4924
AD  - Division of Pediatric Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 
      55905, USA.
AD  - Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
EIN - J Clin Endocrinol Metab. 2024 Apr 19;109(5):e1422. PMID: 38245377
MH  - Adolescent
MH  - Child
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/etiology/complications
MH  - *Pediatric Obesity/complications/epidemiology
MH  - Risk Factors
MH  - *Cardiovascular Diseases/etiology/complications
MH  - Comorbidity
OTO - NOTNLM
OT  - cardiovascular
OT  - childhood obesity
OT  - diabetes
OT  - pathophysiology
OT  - treatment
EDAT- 2023/06/15 19:14
MHDA- 2023/11/27 12:42
CRDT- 2023/06/15 17:25
PHST- 2023/05/03 00:00 [received]
PHST- 2023/11/27 12:42 [medline]
PHST- 2023/06/15 19:14 [pubmed]
PHST- 2023/06/15 17:25 [entrez]
AID - 7199095 [pii]
AID - 10.1210/clinem/dgad361 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Nov 17;108(12):3051-3066. doi: 
      10.1210/clinem/dgad361.