PMID- 37322514
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230619
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 15
IP  - 1
DP  - 2023 Jun 16
TI  - Associations of non-traditional cardiovascular risk factors and body mass index 
      with metabolic syndrome in the Chinese elderly population.
PG  - 129
LID - 10.1186/s13098-023-01047-4 [doi]
LID - 129
AB  - BACKGROUND: Metabolic syndrome (MetS), a clustering of traditional cardiovascular 
      risk factors (CVRF), is currently one of the major global public health burdens. 
      However, associations between MetS and non-traditional CVRF represented by uric 
      acid (UA), homocysteine (HCY) and hypersensitive C-reactive protein (HsCRP) have 
      not been well explored in the elderly population, especially when considering 
      body mass index (BMI). METHODS: Participants from the Shanghai Elderly 
      Cardiovascular Health (SHECH) study cohort in 2017 were analyzed. MetS was 
      defined using the modified American Heart Association/National Heart, Lung, and 
      Blood Institute Scientific Statement. Logistic regression models were used to 
      assess associations of non-traditional CVRF, BMI with MetS. RESULTS: Of the 4360 
      participants analyzed, 2378 (54.5%) had MetS, the mean (SD) UA was 331 (86) 
      micromol/L, and the median (IQR) HCY and HsCRP were 15 (13-18) micromol/L and 1.0 
      (0.5-2.1) mg/L, respectively. Participants with higher non-traditional CVRF 
      tended to have a higher significant risk of MetS (P < 0.001), which did not 
      changed substantially in most population subgroups (P-interaction > 0.05). BMI 
      mediated 43.89% (95%CI: 30.38-57.40%), 37.34% (95% CI: 13.86-60.83%) and 30.99% 
      (95%CI: 13.16-48.83%) of associations of hyperuricemia (HUA), 
      hyperhomocysteinemia (HHCY) and high HsCRP (HHsCRP) with MetS, respectively. 
      Abnormal non-traditional CVRF combined with overweight/obesity greatly increased 
      MetS risk (adjusted OR(95%CI): HUA + Overweight: 5.860(4.059-8.461); 
      6.148(3.707-10.194); HHCY + Overweight: 3.989(3.107-5.121); HHCY + Obese: 
      5.746(4.064-8.123); HHsCRP + Overweight: 4.026(2.906-5.580); HHsCRP + Obese: 
      7.717(4.508-13.210)). CONCLUSIONS: In the Chinese elderly population, HUA, HHCY, 
      and HHsCRP were all significantly and independently associated with MetS, 
      supporting the potential of focusing on non-traditional CVRF interventions for 
      preventing and controlling MetS. BMI played moderate mediating roles in 
      associations between non-traditional CVRF and MetS, and abnormal non-traditional 
      CVRF combined with overweight/obesity had significant synergistic effects on MetS 
      risk, highlighting the importance of better weight management in the elderly 
      population.
CI  - (c) 2023. The Author(s).
FAU - You, Aijun
AU  - You A
AD  - Department of Epidemiology and Public Health, Tongji University School of 
      Medicine, Shanghai, 200092, China.
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China.
AD  - Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical 
      University, Shanghai, 200433, China.
FAU - Li, Yaxin
AU  - Li Y
AD  - Department of Epidemiology and Public Health, Tongji University School of 
      Medicine, Shanghai, 200092, China.
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China.
FAU - Shen, Chaonan
AU  - Shen C
AD  - Department of Epidemiology and Public Health, Tongji University School of 
      Medicine, Shanghai, 200092, China.
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China.
AD  - Institute of Integrated Traditional Chinese and Western Medicine for 
      Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai, 
      200120, China.
FAU - Fan, Huimin
AU  - Fan H
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China.
AD  - Institute of Integrated Traditional Chinese and Western Medicine for 
      Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai, 
      200120, China.
FAU - He, Jia
AU  - He J
AD  - Department of Epidemiology and Public Health, Tongji University School of 
      Medicine, Shanghai, 200092, China.
AD  - Department of Health Statistics, Faculty of Health Service, Naval Medical 
      University, Shanghai, 200433, China.
AD  - Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical 
      University, Shanghai, 200433, China.
FAU - Liu, Zhongmin
AU  - Liu Z
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China.
AD  - Institute of Integrated Traditional Chinese and Western Medicine for 
      Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai, 
      200120, China.
FAU - Xue, Qian
AU  - Xue Q
AD  - Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical 
      University, Shanghai, 200433, China. chyybb@yeah.net.
FAU - Zhang, Yuzhen
AU  - Zhang Y
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China. Yzzhang-tj@tongji.edu.cn.
AD  - Institute of Integrated Traditional Chinese and Western Medicine for 
      Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai, 
      200120, China. Yzzhang-tj@tongji.edu.cn.
FAU - Zheng, Liang
AU  - Zheng L
AD  - Department of Epidemiology and Public Health, Tongji University School of 
      Medicine, Shanghai, 200092, China. zhengliang@tongji.edu.cn.
AD  - Research Center for Translational Medicine, Shanghai East Hospital, Tongji 
      University School of Medicine, Shanghai, 200120, China. zhengliang@tongji.edu.cn.
AD  - Institute of Integrated Traditional Chinese and Western Medicine for 
      Cardiovascular Chronic Diseases, Tongji University School of Medicine, Shanghai, 
      200120, China. zhengliang@tongji.edu.cn.
LA  - eng
GR  - SKJP220227143/the Science and Technology Plan Project of Jiangxi Provincial 
      Health Commission/
PT  - Journal Article
DEP - 20230616
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC10273701
OTO - NOTNLM
OT  - Body mass index
OT  - Cardiovascular disease
OT  - Metabolic syndrome
OT  - Non-traditional cardiovascular risk factors
OT  - The elderly population
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/06/16 01:08
MHDA- 2023/06/16 01:09
PMCR- 2023/06/16
CRDT- 2023/06/15 23:42
PHST- 2023/02/20 00:00 [received]
PHST- 2023/03/29 00:00 [accepted]
PHST- 2023/06/16 01:09 [medline]
PHST- 2023/06/16 01:08 [pubmed]
PHST- 2023/06/15 23:42 [entrez]
PHST- 2023/06/16 00:00 [pmc-release]
AID - 10.1186/s13098-023-01047-4 [pii]
AID - 1047 [pii]
AID - 10.1186/s13098-023-01047-4 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2023 Jun 16;15(1):129. doi: 10.1186/s13098-023-01047-4.