PMID- 37322625
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 0304-4920 (Print)
IS  - 0304-4920 (Linking)
VI  - 66
IP  - 3
DP  - 2023 May-Jun
TI  - Upregulated TNF-alpha and lactate following ERK-SGK1 activation in the spinal dorsal 
      horn underlies chronic postsurgical pain.
PG  - 144-152
LID - 10.4103/cjop.CJOP-D-22-00085 [doi]
AB  - Skin/muscle incision and retraction (SMIR) during surgeries can lead to chronic 
      postsurgical pain (CPSP). The underlying mechanisms are still unclear. In the 
      present study, we showed that SMIR of the thigh induced phosphorylation of 
      extracellular signal-regulated kinase (ERK), followed by serum- and 
      glucocorticoid-inducible kinase-1 (SGK1) activation in the spinal dorsal horn. 
      Intrathecal injection of PD98059, an ERK inhibitor, or GSK650394, a SGK1 
      inhibitor, significantly attenuated mechanical pain hypersensitivity in SMIR 
      rats. The level of tumor necrosis factor alpha and lactate in spinal cord was 
      significantly decreased by PD98059 or GSK650394 injection. Furthermore, PD98059 
      decreased the activation of SGK1 in the spinal dorsal horn. These results 
      indicate that ERK-SGK1 activation followed by proinflammatory mediator release in 
      the spinal dorsal horn underlies CPSP.
FAU - Li, Yuying
AU  - Li Y
AD  - School of Medical Technology and Nursing, Shenzhen Polytechnic, Shenzhen, 
      Guangdong, China.
FAU - Shi, Wenjuan
AU  - Shi W
AD  - Affiliated Shenzhen Maternity and Child Healthcare Hospital, Southern Medical 
      University, Shenzhen, Guangdong, China.
FAU - Dai, Juanli
AU  - Dai J
AD  - Department of Neurology, Xiehe Shenzhen Hospital, Huazhong University of Science 
      and Technology, Shenzhen, Guangdong, China.
FAU - Jia, Qi
AU  - Jia Q
AD  - School of Medical Technology and Nursing, Shenzhen Polytechnic, Shenzhen, 
      Guangdong, China.
FAU - Guo, Gang
AU  - Guo G
AD  - School of Medical Technology and Nursing, Shenzhen Polytechnic, Shenzhen, 
      Guangdong, China.
FAU - Zhang, Yanling
AU  - Zhang Y
AD  - Shenzhen Eye Hospital, Shenzhen, Guangdong, China.
FAU - Zhang, Weihong
AU  - Zhang W
AD  - School of Medical Technology and Nursing, Shenzhen Polytechnic, Shenzhen, 
      Guangdong, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Chin J Physiol
JT  - The Chinese journal of physiology
JID - 7804502
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - 56887611DJ (2-cyclopentyl-4-(5-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl)-benzoic 
      acid)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Extracellular Signal-Regulated MAP Kinases
MH  - *Tumor Necrosis Factor-alpha
MH  - Rats, Sprague-Dawley
MH  - Hyperalgesia
MH  - Lactic Acid
MH  - Pain, Postoperative
MH  - Spinal Cord Dorsal Horn
MH  - Spinal Cord
OTO - NOTNLM
OT  - Chronic postsurgical pain
OT  - ERK
OT  - SGK1
OT  - lactate
OT  - spinal dorsal horn
OT  - tumor necrosis factor alpha
COIS- None
EDAT- 2023/06/16 06:42
MHDA- 2023/06/19 13:08
CRDT- 2023/06/16 00:23
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/06/16 06:42 [pubmed]
PHST- 2023/06/16 00:23 [entrez]
AID - ChinJPhysiol_2023_66_3_144_377576 [pii]
AID - 10.4103/cjop.CJOP-D-22-00085 [doi]
PST - ppublish
SO  - Chin J Physiol. 2023 May-Jun;66(3):144-152. doi: 10.4103/cjop.CJOP-D-22-00085.