PMID- 37323180
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231019
IS  - 2218-6751 (Print)
IS  - 2226-4477 (Electronic)
IS  - 2218-6751 (Linking)
VI  - 12
IP  - 5
DP  - 2023 May 31
TI  - Assessing how lung cancer screening guidelines contribute to racial disparities 
      in screening access.
PG  - 1122-1132
LID - 10.21037/tlcr-22-816 [doi]
AB  - BACKGROUND: Lung cancer (LC) is the leading cause of cancer-related deaths in the 
      United States (U.S.), with non-White people who smoke often bearing the burden of 
      the highest rate of LC mortality. This is often due to later stage diagnoses, 
      leading to poor prognosis and outcomes. We assess here how the eligibility 
      criteria for LC screening set by the U.S. Preventive Services Task Force (USPSTF) 
      and the Centers for Medicare and Medicaid Services (CMS) could contribute to 
      racial disparities in screening access. METHODS: This paper analyzes data from 
      the National Health and Nutrition Examination Survey (NHANES), an annual survey 
      conducted by the Centers for Disease Control and Prevention (CDC) that gathers 
      health and nutrition data from a representative sample of the U.S. population. 
      After excluding those who were ineligible for LC screening, the final cohort of 
      participants was 5,001, which consisted of 2,669 people who formerly smoked and 
      2,332 people who currently smoke. RESULTS: Out of 608 participants who were 
      eligible for LC screening, 77.5% were non-Hispanic White (NHW) and 8.7% were 
      non-Hispanic Black (NHB) participants versus 69.4% and 10.8% among 4,393 
      ineligible participants. Age, pack-years, and age along with pack-years were the 
      most frequent reasons for ineligibility. LC screening ineligible NHW participants 
      were statistically significantly older and had higher mean pack-years than the 
      other racial and ethnic groups. NHB participants among the ineligible group had 
      higher urinary cotinine levels compared to NHW participants. CONCLUSIONS: This 
      paper underscores the need for more individualized risk estimates when 
      determining eligibility for LC screening, which could include biomarkers of 
      smoking exposure. The analysis shows that current screening criteria, which rely 
      solely on factors such as age and pack years, contribute to LC racial 
      disparities.
CI  - 2023 Translational Lung Cancer Research. All rights reserved.
FAU - Ivic-Pavlicic, Tara
AU  - Ivic-Pavlicic T
AD  - Institute for Translational Epidemiology, Icahn School of Medicine at Mount 
      Sinai, New York, NY, USA.
FAU - Joshi, Shivam
AU  - Joshi S
AD  - Institute for Translational Epidemiology, Icahn School of Medicine at Mount 
      Sinai, New York, NY, USA.
FAU - Zegarelli, Angelo
AU  - Zegarelli A
AD  - Institute for Translational Epidemiology, Icahn School of Medicine at Mount 
      Sinai, New York, NY, USA.
FAU - Taioli, Emanuela
AU  - Taioli E
AD  - Institute for Translational Epidemiology, Icahn School of Medicine at Mount 
      Sinai, New York, NY, USA.
AD  - Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New 
      York, NY, USA.
AD  - Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 
      USA.
LA  - eng
PT  - Journal Article
DEP - 20230515
PL  - China
TA  - Transl Lung Cancer Res
JT  - Translational lung cancer research
JID - 101646875
CIN - Transl Lung Cancer Res. 2023 Sep 28;12(9):1834-1837. PMID: 37854162
PMC - PMC10261853
OTO - NOTNLM
OT  - Lung cancer screening
OT  - biomarkers
OT  - cotinine
OT  - low-dose computed tomography (LDCT)
OT  - race
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://tlcr.amegroups.com/article/view/10.21037/tlcr-22-816/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2023/06/16 06:42
MHDA- 2023/06/16 06:43
PMCR- 2023/05/31
CRDT- 2023/06/16 03:55
PHST- 2022/11/17 00:00 [received]
PHST- 2023/04/25 00:00 [accepted]
PHST- 2023/06/16 06:43 [medline]
PHST- 2023/06/16 06:42 [pubmed]
PHST- 2023/06/16 03:55 [entrez]
PHST- 2023/05/31 00:00 [pmc-release]
AID - tlcr-12-05-1122 [pii]
AID - 10.21037/tlcr-22-816 [doi]
PST - ppublish
SO  - Transl Lung Cancer Res. 2023 May 31;12(5):1122-1132. doi: 10.21037/tlcr-22-816. 
      Epub 2023 May 15.