PMID- 37323224
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20230619
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2023
DP  - 2023
TI  - Association between Severity of Diabetic Retinopathy and Cardiac Function in 
      Patients with Type 2 Diabetes.
PG  - 6588932
LID - 10.1155/2023/6588932 [doi]
LID - 6588932
AB  - BACKGROUND: The purpose of this research was to assess the relationship between 
      the severity of diabetic retinopathy (DR) and indexes of left ventricle (LV) 
      structure and function in type 2 diabetes mellitus (T2DM). METHODS: Retrospective 
      analysis of 790 patients with T2DM and preserved LV ejection fraction. 
      Retinopathy stages were classified as no DR, early nonproliferative DR, moderate 
      to severe nonproliferative DR, or proliferative DR. The electrocardiogram was 
      used to assess myocardial conduction function. Echocardiography was used to 
      evaluate myocardial structure and function. RESULTS: Patients were divided into 
      three groups based on the DR status: no DR group (NDR, n = 475), nonproliferative 
      DR group (NPDR, n = 247), and proliferative DR group (PDR, n = 68). LV 
      interventricular septal thickness (IVST) increased significantly with more severe 
      retinopathy (NDR: 10.00 +/- 1.09; NPDR: 10.42 +/- 1.21; and PDR: 10.66 +/- 1.58; P < 
      0.001). Multivariate logistic regression analysis showed that the significant 
      correlation of IVST persisted between subjects with no retinopathy and 
      proliferative DR (odds ratio = 1.35, P = 0.026). Indices of myocardial conduction 
      function were assessed by electrocardiogram differences among groups of 
      retinopathy (all P < 0.001). In multiple-adjusted linear regression analyses, the 
      increasing degree of retinopathy was closely correlated with heart rate (beta = 
      1.593, P = 0.027), PR interval (beta = 4.666, P = 0.001), and QTc interval (beta = 
      8.807, P = 0.005). CONCLUSION: The proliferative DR was independently associated 
      with worse cardiac structure and function by echocardiography. Furthermore, the 
      severity of retinopathy significantly correlated with abnormalities of the 
      electrocardiogram in patients with T2DM.
CI  - Copyright (c) 2023 YanYan Chen et al.
FAU - Chen, YanYan
AU  - Chen Y
AUID- ORCID: 0000-0002-9681-6105
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Li, MengYing
AU  - Li M
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Fu, JianFang
AU  - Fu J
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Liu, XiangYang
AU  - Liu X
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Liu, LiWen
AU  - Liu L
AUID- ORCID: 0000-0001-9838-5727
AD  - Department of Ultrasound, Xijing Hospital, Air Force Medical University, Xi'an, 
      Shaanxi 710032, China.
FAU - Ta, ShengJun
AU  - Ta S
AD  - Department of Ultrasound, Xijing Hospital, Air Force Medical University, Xi'an, 
      Shaanxi 710032, China.
FAU - Lu, ZuoWei
AU  - Lu Z
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Li, ZePing
AU  - Li Z
AD  - Nanchang University Queen Mary School, Nanchang 330038, China.
FAU - Zhou, Jie
AU  - Zhou J
AUID- ORCID: 0000-0002-9711-4316
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
FAU - Li, XiaoMiao
AU  - Li X
AUID- ORCID: 0000-0002-2254-3650
AD  - Department of Endocrinology, Xijing Hospital, Air Force Medical University, 
      Xi'an, Shaanxi 710032, China.
LA  - eng
PT  - Journal Article
DEP - 20230607
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
SB  - IM
MH  - Humans
MH  - *Diabetic Retinopathy
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Retrospective Studies
MH  - Severity of Illness Index
PMC - PMC10266918
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this article.
EDAT- 2023/06/16 06:42
MHDA- 2023/06/19 13:08
PMCR- 2023/06/07
CRDT- 2023/06/16 03:56
PHST- 2022/07/29 00:00 [received]
PHST- 2023/01/26 00:00 [revised]
PHST- 2023/05/05 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/06/16 06:42 [pubmed]
PHST- 2023/06/16 03:56 [entrez]
PHST- 2023/06/07 00:00 [pmc-release]
AID - 10.1155/2023/6588932 [doi]
PST - epublish
SO  - J Diabetes Res. 2023 Jun 7;2023:6588932. doi: 10.1155/2023/6588932. eCollection 
      2023.