PMID- 37323526
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230619
IS  - 1524-5012 (Print)
IS  - 2831-4107 (Electronic)
IS  - 1524-5012 (Linking)
VI  - 23
IP  - 2
DP  - 2023 Summer
TI  - Rate of Intraoperative Crystalloid Administration During Thoracic Surgery Is 
      Causal in Reducing Postoperative Hospital Length of Stay.
PG  - 106-119
LID - 10.31486/toj.22.0113 [doi]
AB  - Background: Studies in thoracic surgery have long raised concerns that 
      intraoperative administration of intravenous fluids exacerbates or causes 
      postoperative complications and hence advocate fluid restriction. Methods: This 
      retrospective 3-year study investigated the role of intraoperative crystalloid 
      administration rates on the duration of postoperative hospital length of stay 
      (phLOS) and on the incidences of previously reported adverse events (AEs) in 222 
      consecutive patients following thoracic surgery. Results: Higher rates of 
      intraoperative crystalloid administration were significantly associated with 
      shorter phLOS (P=0.0006) and with less variance in phLOS. Dose-response curves 
      showed progressive decreases in the postoperative incidences of surgical, 
      cardiovascular, pulmonary, renal, other, and long-term AEs with higher 
      intraoperative crystalloid administration rates. Conclusion: The rate of 
      intravenous crystalloid administration during thoracic surgery was significantly 
      associated with duration of and variance in phLOS, and dose-response curves 
      showed progressive decreases in the incidences of AEs associated with this 
      surgery. We cannot confirm that restrictive intraoperative crystalloid 
      administration benefits patients undergoing thoracic surgery.
CI  - (c)2023 by the author(s); Creative Commons Attribution License (CC BY).
FAU - Smith, Morgan T
AU  - Smith MT
AD  - The University of Queensland Medical School, Ochsner Clinical School, New 
      Orleans, LA.
FAU - Peairs, Ashley D
AU  - Peairs AD
AD  - Department of Anesthesiology and Perioperative Medicine, Ochsner Clinic 
      Foundation, New Orleans, LA.
FAU - Nossaman, Bobby D
AU  - Nossaman BD
AD  - The University of Queensland Medical School, Ochsner Clinical School, New 
      Orleans, LA.
AD  - Department of Anesthesiology and Perioperative Medicine, Ochsner Clinic 
      Foundation, New Orleans, LA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ochsner J
JT  - Ochsner journal
JID - 101125795
PMC - PMC10262950
OTO - NOTNLM
OT  - Colloids
OT  - crystalloid solutions
OT  - intraoperative care
OT  - perfusion
OT  - postoperative complications
OT  - thoracic surgery
EDAT- 2023/06/16 06:42
MHDA- 2023/06/16 06:43
PMCR- 2023/06/01
CRDT- 2023/06/16 03:59
PHST- 2023/06/16 06:43 [medline]
PHST- 2023/06/16 06:42 [pubmed]
PHST- 2023/06/16 03:59 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - toj.22.0113 [pii]
AID - 10.31486/toj.22.0113 [doi]
PST - ppublish
SO  - Ochsner J. 2023 Summer;23(2):106-119. doi: 10.31486/toj.22.0113.