PMID- 37323542
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20231116
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 18
DP  - 2023
TI  - Myeloid-Specific SIRT6 Deletion Protects Against Particulate Matter 
      (PM(2.5))-Induced Airway Inflammation.
PG  - 1135-1144
LID - 10.2147/COPD.S398796 [doi]
AB  - PURPOSE: Particulate matter (PM(2.5)) is a common risk factor for airway 
      inflammation. Alveolar macrophages play a critical role in airway inflammation. 
      Sirtuin 6 (SIRT6) is a class Ill histone deacetylase that exerts an 
      anti-inflammatory effect in airway diseases. However, the role of SIRT6 on 
      PM2.5-induced airway inflammation in macrophages remains unclear. We aimed to 
      determine whether SIRT6 protects against PM(2.5)-induced airway inflammation in 
      macrophages. METHODS: The effect of SIRT6 on PM(2.5)-induced airway inflammation 
      was assessed by using THP1 cells or bone marrow-derived macrophages (BMDMs) 
      exposed to PM(2.5) in vitro and myeloid cell-specific SIRT6 conditional knockout 
      mice (Sirt6(fl/fl)-LysMCre) in vivo. RESULTS: PM2.5 increased SIRT6 expression in 
      THP1 cells, but SIRT6 gene silencing decreased PM2.5 induced inflammatory 
      cytokines in THP1 cells. Moreover, the expression of SIRT6 and inflammatory 
      cytokines was also decreased in BMDMs with myeloid-specific deletion of SIRT6 
      after stimulation of PM(2.5). In vivo, Sirt6(fl/fl)-LysMCre mice substantially 
      decreased airway inflammation in response to PM(2.5) exposure. CONCLUSION: Our 
      results revealed that SIRT6 promotes the PM(2.5)-induced airway inflammation in 
      macrophages and indicated that inhibition of SIRT6 in macrophages may represent 
      therapeutic strategy for airway disorders induced by airborne particulate 
      pollution.
CI  - (c) 2023 Chen et al.
FAU - Chen, Shaopeng
AU  - Chen S
AD  - Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of 
      Guangdong Medical University, Dongguan, People's Republic of China.
AD  - Blood Donation Service Department, Zhanjiang Blood Center, Zhanjiang, People's 
      Republic of China.
FAU - Wu, Mindan
AU  - Wu M
AD  - Department of Pulmonary and Critical Care Medicine, Shantou Central Hospital, 
      Shantou, People's Republic of China.
FAU - Xiong, Zhilin
AU  - Xiong Z
AD  - Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of 
      Guangdong Medical University, Dongguan, People's Republic of China.
FAU - Huang, Jiewen
AU  - Huang J
AD  - Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of 
      Guangdong Medical University, Dongguan, People's Republic of China.
FAU - Lv, Yingying
AU  - Lv Y
AD  - Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of 
      Guangdong Medical University, Dongguan, People's Republic of China.
FAU - Li, Yuyan
AU  - Li Y
AUID- ORCID: 0000-0003-0062-879X
AD  - Department of Pulmonary and Critical Care Medicine, Dongguan Hospital of Southern 
      Medical University, Dongguan, People's Republic of China.
FAU - Zeng, Minjuan
AU  - Zeng M
AD  - Laboratory Animal Center, Guangdong Medical University, Zhanjiang, People's 
      Republic of China.
FAU - Lai, Tianwen
AU  - Lai T
AUID- ORCID: 0000-0001-9921-3425
AD  - Institute of Respiratory Diseases, The First Dongguan Affiliated Hospital of 
      Guangdong Medical University, Dongguan, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230610
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
RN  - 0 (Particulate Matter)
RN  - 0 (Cytokines)
RN  - EC 3.5.1.- (Sirtuins)
RN  - EC 2.4.2.31 (Sirt6 protein, mouse)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Particulate Matter/toxicity
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Inflammation/chemically induced/genetics/prevention & control
MH  - Cytokines/metabolism
MH  - *Sirtuins/genetics
PMC - PMC10266380
OTO - NOTNLM
OT  - SIRT6
OT  - lung inflammation
OT  - macrophage
OT  - particulate matter
COIS- The authors declare no competing interests.
EDAT- 2023/06/16 06:42
MHDA- 2023/06/19 13:08
PMCR- 2023/06/10
CRDT- 2023/06/16 03:59
PHST- 2022/11/23 00:00 [received]
PHST- 2023/04/30 00:00 [accepted]
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/06/16 06:42 [pubmed]
PHST- 2023/06/16 03:59 [entrez]
PHST- 2023/06/10 00:00 [pmc-release]
AID - 398796 [pii]
AID - 10.2147/COPD.S398796 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2023 Jun 10;18:1135-1144. doi: 
      10.2147/COPD.S398796. eCollection 2023.