PMID- 37323820
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230619
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Print)
IS  - 1792-1074 (Linking)
VI  - 26
IP  - 1
DP  - 2023 Jul
TI  - Pleomorphic undifferentiated sarcoma of the mediastinal thymus: A case report and 
      literature review.
PG  - 306
LID - 10.3892/ol.2023.13892 [doi]
LID - 306
AB  - Pleomorphic undifferentiated sarcoma (PUS) of the mediastinal thymus is a rare 
      type of cancer. In the present case report, a 67-year-old female patient 
      presenting a mediastinal mass for >1 year was assessed for clinical 
      characteristics, histopathological, immunohistochemical expression and gene 
      mutation using fluorescence in situ hybridization (FISH), and relevant literature 
      was reviewed. Histological analysis revealed nodular changes of different sizes 
      in the thymus, which consisted of a mixture of pleomorphic and spindle cells. The 
      pleomorphic cells with distinct atypia were giant cells and multinucleated cells 
      with large cell sizes and frequent nuclear divisions. The spindle cells were mild 
      to moderate atypical and arranged in a woven pattern, and nuclear division was 
      rare. Immunohistochemical analysis indicated that vimentin was diffusively 
      expressed in tumor cells. No amplification was found in CDX2 and MDM4 genes using 
      the FISH analysis. In conclusion, mediastinal thymus neoplasm should be 
      considered in the presence of PUS and it is an exclusionary diagnosis based on 
      clinical and pathological examination of the patient.
CI  - Copyright: (c) Chen et al.
FAU - Chen, Xiaodan
AU  - Chen X
AD  - Department of Pathology, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang 311200, P.R. China.
FAU - Yang, Junjie
AU  - Yang J
AD  - Department of Pathology, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang 311200, P.R. China.
FAU - Huang, Bin
AU  - Huang B
AD  - Department of Pathology, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang 311200, P.R. China.
FAU - Liu, Hongsheng
AU  - Liu H
AD  - Department of Pathology, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang 311200, P.R. China.
FAU - Chen, Lijiang
AU  - Chen L
AD  - Department of Pathology, The First People's Hospital of Xiaoshan District, 
      Hangzhou, Zhejiang 311200, P.R. China.
LA  - eng
PT  - Case Reports
DEP - 20230601
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC10265395
OTO - NOTNLM
OT  - clinicopathology
OT  - mediastinal thymus
OT  - pleomorphism
OT  - undifferentiated sarcoma
COIS- The authors declare that they have no competing interests.
EDAT- 2023/06/16 06:42
MHDA- 2023/06/16 06:43
PMCR- 2023/06/01
CRDT- 2023/06/16 04:03
PHST- 2023/02/02 00:00 [received]
PHST- 2023/05/05 00:00 [accepted]
PHST- 2023/06/16 06:43 [medline]
PHST- 2023/06/16 06:42 [pubmed]
PHST- 2023/06/16 04:03 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - OL-26-1-13892 [pii]
AID - 10.3892/ol.2023.13892 [doi]
PST - epublish
SO  - Oncol Lett. 2023 Jun 1;26(1):306. doi: 10.3892/ol.2023.13892. eCollection 2023 
      Jul.