PMID- 37326107
OWN - NLM
STAT- MEDLINE
DCOM- 20230705
LR  - 20230705
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 14
IP  - 13
DP  - 2023 Jul 3
TI  - Human milk phospholipid analog improved the digestion and absorption of 
      1,3-dioleoyl-2-palmitoyl-glycerol.
PG  - 6106-6114
LID - 10.1039/d2fo03759a [doi]
AB  - The present study investigated the effects of a human milk phospholipid analog 
      (HPLA) on the digestion and absorption of 1,3-dioleoyl-2-palmitoyl-glycerol 
      (OPO). The HPLA contained 26.48% phosphatidylethanolamine (PE), 24.64% 
      phosphatidylcholine (PC), 36.19% sphingomyelin (SM), 6.35% phosphatidylinositol 
      (PI), and 6.32% phosphatidylserine (PS), with 40.51% C16:0, 17.02% C18:0, 29.19% 
      C18:1, and 13.26% C18:2. The HPLA prevented OPO from hydrolysis during the in 
      vitro gastric phase, while it facilitated the digestion of OPO during the in 
      vitro intestinal stage, resulting in the production of large amounts of 
      diglycerides (DAGs) and monoglycerides (MAGs). In vivo experimental results 
      showed that the HPLA might increase the gastric emptying rate of OPO and increase 
      the hydrolysis and absorption of OPO at an early stage of intestinal digestion. 
      Notably, fatty acids in the serum of the OPO group decreased to their initial 
      value at 5 h, while the serum of the OPO + HPLA (OPOH) group still contained a 
      high level of fatty acids indicating that the HPLA was helpful in maintaining 
      serum lipid at a high level, which might be beneficial for sustainably providing 
      energy for babies. The present study provides data support for the potential 
      application of Chinese human milk phospholipid analogs in infant formulas.
FAU - Wei, Teng
AU  - Wei T
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang 330047, Jiangxi, China. lijing66@ncu.edu.cn.
FAU - Wu, Yanping
AU  - Wu Y
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang 330047, Jiangxi, China. lijing66@ncu.edu.cn.
FAU - Sun, Yong
AU  - Sun Y
AUID- ORCID: 0000-0003-2324-7180
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang 330047, Jiangxi, China. lijing66@ncu.edu.cn.
FAU - Deng, Zeyuan
AU  - Deng Z
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang 330047, Jiangxi, China. lijing66@ncu.edu.cn.
FAU - Li, Jing
AU  - Li J
AUID- ORCID: 0000-0002-2271-7761
AD  - State Key Laboratory of Food Science and Technology, Nanchang University, 
      Nanchang 330047, Jiangxi, China. lijing66@ncu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230703
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 21I29V2935 (2-palmitoylglycerol)
RN  - 0 (Phospholipids)
RN  - 306-23-0 (4-hydroxyphenyllactic acid)
RN  - 0 (Triglycerides)
RN  - 0 (Fatty Acids)
SB  - IM
MH  - Infant
MH  - Humans
MH  - *Phospholipids
MH  - *Milk, Human
MH  - Triglycerides
MH  - Fatty Acids
MH  - Digestion
EDAT- 2023/06/16 13:10
MHDA- 2023/07/05 06:42
CRDT- 2023/06/16 06:37
PHST- 2023/07/05 06:42 [medline]
PHST- 2023/06/16 13:10 [pubmed]
PHST- 2023/06/16 06:37 [entrez]
AID - 10.1039/d2fo03759a [doi]
PST - epublish
SO  - Food Funct. 2023 Jul 3;14(13):6106-6114. doi: 10.1039/d2fo03759a.