PMID- 37326123
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230724
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 47
IP  - 8
DP  - 2023 Aug 1
TI  - ALK-positive Large B-Cell Lymphoma With Multiple Epithelial Antigen Expression 
      and PABPC1::ALK Fusion : A Novel Molecular Alteration.
PG  - 950-954
LID - 10.1097/PAS.0000000000002069 [doi]
AB  - Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (LBCL) is a very 
      rare type of LBCL with an aggressive clinical course and poor prognosis. This 
      diagnosis can be challenging given the varied morphology (immunoblastic, 
      plasmablastic, or anaplastic), frequent lack of B-cell antigens, and especially 
      in cases with expression of epithelial antigens. Here, we report a case of 
      ALK-positive LBCL with unusual expression of 4 epithelial-associated markers 
      (AE1/AE3, CK8/18, EMA, and GATA3) and novel poly(A) binding protein cytoplasmic 1 
      (PABPC1) :: ALK fusion which has not been previously reported in this entity. 
      This case also emphasizes the use of comprehensive immunophenotyping that 
      includes multiple lineage-specific antibodies when faced with a malignancy 
      without a clear differentiation to avoid misdiagnosis. This case only achieved 
      partial response to combination chemotherapy, radiation, and ALK inhibitor 
      regimens, and furthers our understanding of this uncommon lymphoma.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Fu, Jian Jeff
AU  - Fu JJ
AD  - Department of Pathology and Laboratory Medicine, Temple University Health System.
FAU - Seth, Anjali
AU  - Seth A
AD  - Department of Pathology and Laboratory Medicine, Temple University Health System.
FAU - Ali, Nadia
AU  - Ali N
AD  - Department of Medicine Section of Hematology, Temple University Hospital, 
      Philadelphia, PA.
FAU - Chandar, Ashwin
AU  - Chandar A
AD  - Department of Medicine Section of Hematology, Temple University Hospital, 
      Philadelphia, PA.
FAU - Bains, Ashish
AU  - Bains A
AUID- ORCID: 0000-0003-0421-8819
AD  - Department of Pathology and Laboratory Medicine, Temple University Health System.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230619
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
SB  - IM
MH  - Humans
MH  - *Receptor Protein-Tyrosine Kinases/genetics/metabolism
MH  - Anaplastic Lymphoma Kinase/genetics
MH  - *Lymphoma, Large B-Cell, Diffuse/diagnosis
MH  - Plasma Cells/pathology
COIS- Conflicts of Interest and Source of Funding: The authors have disclosed that they 
      have no significant relationships with, or financial interest in, any commercial 
      companies pertaining to this article.
EDAT- 2023/06/16 13:10
MHDA- 2023/07/19 06:43
CRDT- 2023/06/16 06:37
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/06/16 13:10 [pubmed]
PHST- 2023/06/16 06:37 [entrez]
AID - 00000478-990000000-00183 [pii]
AID - 10.1097/PAS.0000000000002069 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2023 Aug 1;47(8):950-954. doi: 10.1097/PAS.0000000000002069. 
      Epub 2023 Jun 19.