PMID- 37326824
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20230922
IS  - 1572-994X (Electronic)
IS  - 0920-8569 (Linking)
VI  - 59
IP  - 5
DP  - 2023 Oct
TI  - Zika virus infection induces expression of NRF2 and antioxidant systems in 
      trophoblast cells.
PG  - 781-785
LID - 10.1007/s11262-023-02014-x [doi]
AB  - The nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor 
      that plays a critical role in the xenobiotic and stress responses. During viral 
      infection, NRF2 can modulate the host metabolism and innate immunity; however, 
      the most common activity of NRF2 in viral diseases is controlling reactive oxygen 
      species (ROS). The Zika virus (ZIKV) is involved in a vertical infection in 
      pregnancy, with reported fetal health consequences. However, the possibility that 
      ZIKV regulates NRF2 expression in placental trophoblasts has not been 
      investigated. In this report, we evaluated the upregulation of NRF2 and 
      antioxidant enzymes in a trophoblast-like cell. These findings could help us 
      understand the antioxidant mechanism underlying the ZIKV infection in the 
      placenta during pregnancy.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Cervantes, Manuel Adrian Velazquez
AU  - Cervantes MAV
AD  - Laboratorio de Virologia Perinatal y Diseno Molecular de Antigenos y 
      Biomarcadores, Departamento de Inmuno-Bioquimica, Instituto Nacional de 
      Perinatologia "Isidro Espinosa de los Reyes", Ciudad de Mexico, Mexico.
FAU - Martinez, Julio Angel Vazquez
AU  - Martinez JAV
AD  - Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
FAU - Garcia, Luis Didider Gonzalez
AU  - Garcia LDG
AD  - Laboratorio de Virologia Perinatal y Diseno Molecular de Antigenos y 
      Biomarcadores, Departamento de Inmuno-Bioquimica, Instituto Nacional de 
      Perinatologia "Isidro Espinosa de los Reyes", Ciudad de Mexico, Mexico.
FAU - Ortega, Orestes Lopez
AU  - Ortega OL
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM) U1151, 
      Institut Necker Enfants Malades, Universite Paris Descartes, Sorbonne Paris Cite, 
      Paris, France.
FAU - Romero, Haruki Arevalo
AU  - Romero HA
AD  - Laboratorio de Inmunologia y Microbiologia Molecular, Division Academica 
      Multidisciplinaria de Jalpa de Mendez, Universidad Juarez Autonoma de Tabasco, 
      Jalpa de Mendez, Mexico.
FAU - Estrada, Araceli Montoya
AU  - Estrada AM
AD  - Coordinacion de Ginecologia y Endocrinologia Perinatal, Instituto Nacional de 
      Perinatologia "Isidro Espinosa de los Reyes", Ciudad de Mexico, Mexico.
FAU - Castillo, Macario Martinez
AU  - Castillo MM
AD  - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, 
      Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron, Casco de Santo 
      Tomas, 11340, Ciudad de Mexico, Mexico.
FAU - Pliego, Arturo Flores
AU  - Pliego AF
AD  - Departamento de Inmuno-Bioquimica, Instituto Nacional de Perinatologia "Isidro 
      Espinosa de los Reyes", Ciudad de Mexico, Mexico.
FAU - Reyes, Guadalupe Leon
AU  - Reyes GL
AD  - Laboratorio de Genomica del Metabolismo Oseo, Instituto Nacional de Medicina 
      Genomica, Ciudad de Mexico, Mexico.
FAU - Repetto, Addy Cecilia Helguera
AU  - Repetto ACH
AD  - Departamento de Inmuno-Bioquimica, Instituto Nacional de Perinatologia "Isidro 
      Espinosa de los Reyes", Ciudad de Mexico, Mexico.
FAU - Cordero, Julio Garcia
AU  - Cordero JG
AD  - Departamento de Biomedicina Molecular, CINVESTAV IPN, Av. IPN # 2508 Col. San 
      Pedro Zacatenco, 07360, Mexico, D.F., Mexico.
FAU - Juarez, Moises Leon
AU  - Juarez ML
AD  - Laboratorio de Virologia Perinatal y Diseno Molecular de Antigenos y 
      Biomarcadores, Departamento de Inmuno-Bioquimica, Instituto Nacional de 
      Perinatologia "Isidro Espinosa de los Reyes", Ciudad de Mexico, Mexico. 
      moisesleoninper@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20230616
PL  - United States
TA  - Virus Genes
JT  - Virus genes
JID - 8803967
RN  - 0 (Antioxidants)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
SB  - IM
MH  - Female
MH  - Humans
MH  - Pregnancy
MH  - Antioxidants/metabolism
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - Placenta
MH  - Trophoblasts/metabolism
MH  - *Zika Virus/genetics
MH  - *Zika Virus Infection
OTO - NOTNLM
OT  - Oxidative stress
OT  - Placenta
OT  - ROS
OT  - Trophoblast
OT  - Zika virus
EDAT- 2023/06/16 13:10
MHDA- 2023/09/14 06:42
CRDT- 2023/06/16 11:15
PHST- 2023/03/08 00:00 [received]
PHST- 2023/06/08 00:00 [accepted]
PHST- 2023/09/14 06:42 [medline]
PHST- 2023/06/16 13:10 [pubmed]
PHST- 2023/06/16 11:15 [entrez]
AID - 10.1007/s11262-023-02014-x [pii]
AID - 10.1007/s11262-023-02014-x [doi]
PST - ppublish
SO  - Virus Genes. 2023 Oct;59(5):781-785. doi: 10.1007/s11262-023-02014-x. Epub 2023 
      Jun 16.