PMID- 37328507
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20231116
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jun 16
TI  - Triple network model of brain connectivity changes related to adverse mood 
      effects in an oral contraceptive placebo-controlled trial.
PG  - 209
LID - 10.1038/s41398-023-02470-x [doi]
LID - 209
AB  - Combined oral contraceptives (COC) are among the most commonly used contraceptive 
      methods worldwide, and mood side effects are the major reason for discontinuation 
      of treatment. We here investigate the directed connectivity patterns associated 
      with the mood side effects of an androgenic COC in a double-blind randomized, 
      placebo-controlled trial in women with a history of affective COC side effects 
      (n = 34). We used spectral dynamic causal modeling on a triple network model 
      consisting of the default mode network (DMN), salience network (SN) and executive 
      control network (ECN). Within this framework, we assessed the treatment-related 
      changes in directed connectivity associated with adverse mood side effects. 
      Overall, during COC use, we found a pattern of enhanced connectivity within the 
      DMN and decreased connectivity within the ECN. The dorsal anterior cingulate 
      cortex (SN) mediates an increased recruitment of the DMN by the ECN during 
      treatment. Mood lability was the most prominent COC-induced symptom and also 
      arose as the side effect most consistently related to connectivity changes. 
      Connections that were related to increased mood lability showed increased 
      connectivity during COC treatment, while connections that were related to 
      decreased mood lability showed decreased connectivity during COC treatment. Among 
      these, the connections with the highest effect size could also predict the 
      participants' treatment group above chance.
CI  - (c) 2023. The Author(s).
FAU - Hidalgo-Lopez, Esmeralda
AU  - Hidalgo-Lopez E
AUID- ORCID: 0000-0001-8521-8970
AD  - Department of Psychology, University of Salzburg, Salzburg, Austria. 
      esmehl@umich.edu.
AD  - Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria. 
      esmehl@umich.edu.
AD  - Department of Psychology, University of Michigan, Ann Arbor, MI, USA. 
      esmehl@umich.edu.
AD  - Department of Anesthesiology, Chronic Pain and Fatigue Research Center, 
      University of Michigan, Ann Arbor, MI, USA. esmehl@umich.edu.
FAU - Engman, Jonas
AU  - Engman J
AUID- ORCID: 0000-0002-3648-3652
AD  - Department of Psychology, Uppsala University, 751 85, Uppsala, Sweden.
FAU - Poromaa, Inger Sundstrom
AU  - Poromaa IS
AUID- ORCID: 0000-0002-2491-2042
AD  - Department of Women's and Children's Health, Uppsala University, 751 85, Uppsala, 
      Sweden.
AD  - Centre for Women's Mental Health during the Reproductive Lifespan, Uppsala 
      University, 751 85, Uppsala, Sweden.
FAU - Gingnell, Malin
AU  - Gingnell M
AD  - Department of Psychology, Uppsala University, 751 85, Uppsala, Sweden.
AD  - Department of Women's and Children's Health, Uppsala University, 751 85, Uppsala, 
      Sweden.
AD  - Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
FAU - Pletzer, Belinda
AU  - Pletzer B
AD  - Department of Psychology, University of Salzburg, Salzburg, Austria. 
      belinda.pletzer@plus.ac.at.
AD  - Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria. 
      belinda.pletzer@plus.ac.at.
LA  - eng
GR  - Starting Grant 850953/EC | EU Framework Programme for Research and Innovation 
      H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 
      Excellent Science - European Research Council)/
GR  - Starting Grant 850953/EC | EU Framework Programme for Research and Innovation 
      H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 
      Excellent Science - European Research Council)/
GR  - K2008-54X-200642-01-3/Vetenskapsradet (Swedish Research Council)/
GR  - K2008-54X-200642-01-3/Vetenskapsradet (Swedish Research Council)/
GR  - K2008-54X-200642-01-3/Vetenskapsradet (Swedish Research Council)/
GR  - 2007-1955/Forskningsradet om Halsa, Arbetsliv och Valfard (Swedish Research 
      Council for Health, Working Life and Welfare)/
GR  - 2007-2116/Forskningsradet om Halsa, Arbetsliv och Valfard (Swedish Research 
      Council for Health, Working Life and Welfare)/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230616
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Contraceptives, Oral, Combined)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Brain/diagnostic imaging
MH  - *Affect
MH  - Brain Mapping
MH  - Contraceptives, Oral, Combined/adverse effects
MH  - Contraception
MH  - Magnetic Resonance Imaging
PMC - PMC10276024
COIS- Over the past three years, I. Sundstrom-Poromaa has served occasionally on 
      advisory boards or acted as invited speaker at scientific meetings for Bayer 
      Health Care, Gedeon Richter, Peptonics, Shire/Takeda, and Sandoz. None of the 
      other authors has any conflicts of interest.
EDAT- 2023/06/17 05:11
MHDA- 2023/06/19 16:16
PMCR- 2023/06/16
CRDT- 2023/06/16 23:18
PHST- 2022/08/16 00:00 [received]
PHST- 2023/05/12 00:00 [accepted]
PHST- 2023/05/02 00:00 [revised]
PHST- 2023/06/19 16:16 [medline]
PHST- 2023/06/17 05:11 [pubmed]
PHST- 2023/06/16 23:18 [entrez]
PHST- 2023/06/16 00:00 [pmc-release]
AID - 10.1038/s41398-023-02470-x [pii]
AID - 2470 [pii]
AID - 10.1038/s41398-023-02470-x [doi]
PST - epublish
SO  - Transl Psychiatry. 2023 Jun 16;13(1):209. doi: 10.1038/s41398-023-02470-x.