PMID- 37328790
OWN - NLM
STAT- MEDLINE
DCOM- 20230619
LR  - 20231120
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Jun 16
TI  - H-type hypertension is a risk factor for chronic total coronary artery occlusion: 
      a cross-sectional study from southwest China.
PG  - 301
LID - 10.1186/s12872-023-03345-1 [doi]
LID - 301
AB  - BACKGROUND: Chronic total coronary occlusion (CTO) is serious and the "last 
      bastion" of percutaneous coronary intervention. Hypertension and 
      hyperhomocysteinemia (HHCY) are synergistic and significantly increase 
      cardiovascular event risk. The relationship between H-type hypertension and CTO 
      remains unclear; thus, this cross-sectional study investigated this potential 
      association. METHODS: Between January 2018 and June 2022, 1446 individuals from 
      southwest China were recruited to participate in this study. CTO was defined as 
      complete coronary artery occlusion persisting for over three months. H-type 
      hypertension was defined as hypertension with plasma homocysteine 
      levels >/= 15 micromol/L. Multivariate logistic regression models were applied to 
      assess the association between H-type hypertension and CTO. Receiver operating 
      characteristic (ROC) curves were generated to determine the accuracy of H-type 
      hypertension in predicting CTO. RESULTS: Of the 1446 individuals, 397 had CTO, 
      and 545 had H-type hypertension. After multivariate adjustment, the odds ratio 
      (OR) for CTO in individuals with H-type hypertension was 2.3-fold higher (95% CI 
      1.01-5.26) than that in healthy controls. The risk of CTO is higher in 
      individuals with H-type hypertension than in those with isolated HHCY and 
      hypertension. The area under the ROC curve for CTO was 0.685 (95% CI, 
      0.653-0.717) for H-type hypertension. CONCLUSIONS: In southwest China, H-type 
      hypertension is significantly related to the occurrence of CTO. TRIAL 
      REGISTRATION: This retrospective study was registered with the Chinese Clinical 
      Trials Registry ( http://www.chictr.org.cn , ChiCTR2100050519.2.2).
CI  - (c) 2023. The Author(s).
FAU - Xiao, Kaiyong
AU  - Xiao K
AD  - Department of Cardiology, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China. keyea1@126.com.
FAU - Xv, Zhe
AU  - Xv Z
AD  - Department of Pediatric Medicine, Guangyuan Central Hospital, 16 Jingxiangzi, 
      Lizhou District, Guangyuan, 628017, Sichuan, China.
FAU - Xv, Yuling
AU  - Xv Y
AD  - Sterilization Supply Center, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China.
FAU - Wang, Jianping
AU  - Wang J
AD  - Department of Cardiology, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China.
FAU - Xiao, Lian
AU  - Xiao L
AD  - Department of Cardiology, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China.
FAU - Kang, Zhou
AU  - Kang Z
AD  - Department of Medical Statistics, Guangyuan Central Hospital, 16 Jingxiangzi, 
      Lizhou District, Guangyuan, 628017, Sichuan, China.
FAU - Zhu, Jianhui
AU  - Zhu J
AD  - Department of Cardiology, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China.
FAU - He, Zhongwei
AU  - He Z
AD  - Department of Cardiology, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China.
FAU - Huang, Guan
AU  - Huang G
AD  - Medical Laboratory Center, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou 
      District, Guangyuan, 628017, Sichuan, China.
LA  - eng
SI  - ChiCTR/ChiCTR2100050519
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230616
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Humans
MH  - *Coronary Occlusion/diagnostic imaging/epidemiology
MH  - Cross-Sectional Studies
MH  - Treatment Outcome
MH  - Coronary Vessels
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Hypertension/diagnosis/epidemiology
MH  - *Percutaneous Coronary Intervention
MH  - Chronic Disease
MH  - Registries
MH  - Coronary Angiography
PMC - PMC10273712
OTO - NOTNLM
OT  - Chronic total coronary occlusion
OT  - Coronary artery disease
OT  - Coronary occlusion
OT  - H-type hypertension
OT  - Homocysteine
OT  - Hyperhomocysteinemia
COIS- The authors declare no competing interests.
EDAT- 2023/06/17 05:11
MHDA- 2023/06/19 16:16
PMCR- 2023/06/16
CRDT- 2023/06/16 23:36
PHST- 2023/03/31 00:00 [received]
PHST- 2023/06/13 00:00 [accepted]
PHST- 2023/06/19 16:16 [medline]
PHST- 2023/06/17 05:11 [pubmed]
PHST- 2023/06/16 23:36 [entrez]
PHST- 2023/06/16 00:00 [pmc-release]
AID - 10.1186/s12872-023-03345-1 [pii]
AID - 3345 [pii]
AID - 10.1186/s12872-023-03345-1 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2023 Jun 16;23(1):301. doi: 10.1186/s12872-023-03345-1.