PMID- 37329155
OWN - NLM
STAT- MEDLINE
DCOM- 20230907
LR  - 20230907
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 37
IP  - 9
DP  - 2023 Sep
TI  - Anti-inflammatory effect of dictamnine on allergic rhinitis via suppression of 
      the LYN kinase-mediated molecular signaling pathway during mast cell activation.
PG  - 4236-4250
LID - 10.1002/ptr.7904 [doi]
AB  - Mast cells (MCs) are important therapeutic targets for allergic diseases. 
      High-affinity immunoglobulin E (IgE) Fc receptors (FcepsilonRI) trigger abnormal 
      activation of MCs. Allergic rhinitis (AR) is an IgE-mediated antigen inhalation 
      reaction that occurs in the nasal mucosa. MC aggravation and dysfunction were 
      observed during the early stages of AR pathogenesis. Herb-derived dictamnine 
      exhibits anti-inflammatory effects. Here, we investigated the pharmacological 
      effects of herb-derived dictamnine on IgE-induced activation of MCs and an 
      ovalbumin (OVA)-induced murine AR model. The results indicated that dictamnine 
      attenuated OVA-induced local allergic reactions and reduced body temperature in 
      OVA-challenged mice with active systemic anaphylaxis. Additionally, dictamnine 
      decreased the frequency of nasal rubbing and sneezing in an OVA-induced murine AR 
      model. Moreover, dictamnine inhibited FcepsilonRI-activated MC activation in a 
      dose-dependent manner without causing cytotoxicity, reduced the activation of the 
      tyrosine kinase LYN in LAD2 cells, and downregulated the phosphorylation of 
      PLCgamma1, IP3R, PKC, Erk1/2, and Akt, which are downstream of LYN. In conclusion, 
      dictamnine suppressed the OVA-stimulated murine model of AR and activated 
      IgE-induced MCs via the LYN kinase-mediated molecular signaling pathway, 
      suggesting that dictamnine may be a promising treatment for AR.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Liu, Rui
AU  - Liu R
AUID- ORCID: 0000-0003-1235-4263
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
FAU - Zhang, Yonghui
AU  - Zhang Y
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
FAU - Wang, Yuejin
AU  - Wang Y
AUID- ORCID: 0000-0002-0833-211X
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
FAU - Huang, Yihan
AU  - Huang Y
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
FAU - Gao, Jiapan
AU  - Gao J
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
FAU - Tian, Xi
AU  - Tian X
AD  - Department of Nephrology, The Affiliated Hospital of Northwest University, Xi'an, 
      China.
FAU - Ma, Tianyou
AU  - Ma T
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
FAU - Zhang, Tao
AU  - Zhang T
AUID- ORCID: 0000-0003-1823-7164
AD  - School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
LA  - eng
GR  - 81872837/National Natural Science Foundation of China/
GR  - 81903572/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230616
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - HQZ3798D0A (dictamnine)
RN  - 9006-59-1 (Ovalbumin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Ovalbumin
MH  - *Mast Cells
MH  - Immunoglobulin E/metabolism
MH  - Signal Transduction
MH  - *Rhinitis, Allergic/drug therapy
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Mice, Inbred BALB C
MH  - Disease Models, Animal
OTO - NOTNLM
OT  - LYN kinase
OT  - allergic rhinitis
OT  - dictamnine
OT  - inflammation
OT  - mast cells
EDAT- 2023/06/17 09:42
MHDA- 2023/09/07 06:42
CRDT- 2023/06/17 03:07
PHST- 2023/04/14 00:00 [revised]
PHST- 2022/11/24 00:00 [received]
PHST- 2023/05/19 00:00 [accepted]
PHST- 2023/09/07 06:42 [medline]
PHST- 2023/06/17 09:42 [pubmed]
PHST- 2023/06/17 03:07 [entrez]
AID - 10.1002/ptr.7904 [doi]
PST - ppublish
SO  - Phytother Res. 2023 Sep;37(9):4236-4250. doi: 10.1002/ptr.7904. Epub 2023 Jun 16.