PMID- 37330336
OWN - NLM
STAT- MEDLINE
DCOM- 20230908
LR  - 20230908
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 47
IP  - 3
DP  - 2023 Sep
TI  - Opposing impacts of HLA-G haplotypes PROMO-G010104-UTR-3 and 
      PROMO-G010101b/c-UTR-4 on risk of recurrent implantation failure.
PG  - 103225
LID - S1472-6483(23)00272-9 [pii]
LID - 10.1016/j.rbmo.2023.04.016 [doi]
AB  - RESEARCH QUESTION: The human leukocyte antigen (HLA) class Ib molecules HLA-F and 
      HLA-G are implicated in pregnancy success, but how do HLA-G and HLA-F genetic 
      polymorphisms impact recurrent implantation failure (RIF)? DESIGN: Prospective 
      cohort study at a fertility clinic including a cohort of 84 women experiencing 
      RIF and 35 IVF controls to assess the influence of HLA-G haplotypes and 
      diplotypes and HLA-F single nucleotide polymorphisms (SNP) on RIF. RESULTS: 
      Over-representation trends for HLA-F SNP genotypes rs1362126, rs2523405 and 
      rs2523393, previously linked with a short time-to-pregnancy, were detected in 
      female control groups compared with RIF patients with no identified pathology 
      linked to infertility. The HLA-G promoter haplotype PROMO-G010101b/c linked with 
      the HLA-G 3'-untranslated region (3'UTR) haplotype UTR-4, which previously has 
      been associated with positive IVF outcome and pregnancy success, was less 
      frequent in the RIF group. For RIF patients carrying the UTR-4 haplotype, the 
      odds ratio (OR) was 0.27 (95% CI 0.12-0.66; P = 0.0044, P(c) = 0.026). The HLA-G 
      PROMO-G010104-UTR-3 haplotype was associated with an increased risk of RIF. For 
      RIF patients carrying the UTR-3 haplotype, the OR was 5.86 (95% CI 1.52-26.23; 
      P = 0.0115, P(c) = 0.069). CONCLUSIONS: These results show that specific HLA-G 
      haplotypes based on the promoter region and the 3'UTR are either associated with 
      an increased risk of reduced fertility, including the manifestation of RIF, and 
      lower chance of achieving pregnancy, or with a reduced risk of experiencing RIF.
CI  - Copyright (c) 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Papuchova, Henrieta
AU  - Papuchova H
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department 
      of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research 
      Consortium, Zealand University Hospital, Denmark.
FAU - Saxtorph, Malene Hviid
AU  - Saxtorph MH
AD  - Department of Clinical Medicine, University of Copenhagen, Denmark; The 
      ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department 
      of Gynecology, Obstetrics and Fertility, Zealand University Hospital, Denmark.
FAU - Hallager, Trine
AU  - Hallager T
AD  - The ReproHealth Research Consortium, Zealand University Hospital, Denmark; 
      Department of Pathology, Zealand University Hospital, Denmark.
FAU - Jepsen, Ida E
AU  - Jepsen IE
AD  - Department of Clinical Medicine, University of Copenhagen, Denmark; The 
      ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department 
      of Gynecology, Obstetrics and Fertility, Zealand University Hospital, Denmark.
FAU - Eriksen, Jens O
AU  - Eriksen JO
AD  - The ReproHealth Research Consortium, Zealand University Hospital, Denmark; 
      Department of Pathology, Zealand University Hospital, Denmark.
FAU - Persson, Gry
AU  - Persson G
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department 
      of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research 
      Consortium, Zealand University Hospital, Denmark.
FAU - Funck, Tina
AU  - Funck T
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department 
      of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research 
      Consortium, Zealand University Hospital, Denmark.
FAU - Weisdorf, Iben
AU  - Weisdorf I
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department 
      of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research 
      Consortium, Zealand University Hospital, Denmark.
FAU - Macklon, Nicholas
AU  - Macklon N
AD  - Department of Clinical Medicine, University of Copenhagen, Denmark; The 
      ReproHealth Research Consortium, Zealand University Hospital, Denmark; Department 
      of Gynecology, Obstetrics and Fertility, Zealand University Hospital, Denmark; 
      London Women's Clinic, London, UK.
FAU - Larsen, Lise Grupe
AU  - Larsen LG
AD  - The ReproHealth Research Consortium, Zealand University Hospital, Denmark; 
      Department of Pathology, Zealand University Hospital, Denmark.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TVF
AD  - Department of Clinical Biochemistry, Centre for Immune Regulation and 
      Reproductive Immunology (CIRRI), Zealand University Hospital, Denmark; Department 
      of Clinical Medicine, University of Copenhagen, Denmark; The ReproHealth Research 
      Consortium, Zealand University Hospital, Denmark. Electronic address: 
      tvh@regionsjaelland.dk.
LA  - eng
PT  - Journal Article
DEP - 20230503
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (HLA-G Antigens)
RN  - 0 (3' Untranslated Regions)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Haplotypes
MH  - *HLA-G Antigens/genetics
MH  - Gene Frequency
MH  - 3' Untranslated Regions
MH  - Prospective Studies
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - HLA-F
OT  - HLA-G
OT  - Haplotypes
OT  - Pregnancy
OT  - Recurrent implantation failure
EDAT- 2023/06/18 01:07
MHDA- 2023/09/08 06:43
CRDT- 2023/06/17 21:54
PHST- 2023/03/05 00:00 [received]
PHST- 2023/04/24 00:00 [revised]
PHST- 2023/04/26 00:00 [accepted]
PHST- 2023/09/08 06:43 [medline]
PHST- 2023/06/18 01:07 [pubmed]
PHST- 2023/06/17 21:54 [entrez]
AID - S1472-6483(23)00272-9 [pii]
AID - 10.1016/j.rbmo.2023.04.016 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2023 Sep;47(3):103225. doi: 10.1016/j.rbmo.2023.04.016. 
      Epub 2023 May 3.