PMID- 37332011
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 38
IP  - 10
DP  - 2023 Oct
TI  - Relationship between gluten availability and celiac disease prevalence: A 
      geo-epidemiologic systematic review.
PG  - 1695-1709
LID - 10.1111/jgh.16260 [doi]
AB  - Celiac disease is a global disease requiring genetic susceptibility and gluten 
      exposure to trigger immune-mediated enteropathy. The effect of the degree of 
      gluten-containing grain availability on celiac disease prevalence is unknown. Our 
      objective was to compare country-based gluten availability to celiac prevalence 
      using a systematic literature review. We searched MEDLINE, Embase, Cochrane, and 
      Scopus until May 2021. We included population-based serum screening with 
      confirmatory testing (second serological study or small intestine biopsy) and 
      excluded specific, high-risk, or referral populations. We determined 
      country-specific gluten availability using the United Nations food balance for 
      wheat, barley, and rye. Human leukocyte antigen (HLA) frequencies were obtained 
      from allelefrequencies.net. The primary outcome was association between 
      gluten-containing grain availability and celiac disease prevalence. Generalized 
      linear mixed models method with Poisson's link was used for analysis. We 
      identified 5641 articles and included 120 studies on 427 146 subjects from 41 
      countries. Celiac disease prevalence was 0-3.1%, median 0.75% (interquartile 
      range 0.35, 1.22). Median wheat supply was 246 g/capita/day (interquartile range 
      214.8, 360.7). The risk ratio (RR) for wheat availability on celiac disease was 
      1.002 (95% confidence interval [CI]: 1.0001, 1.004, P = 0.036). A protective 
      association was seen with barley, RR 0.973 (95% CI: 0.956, 0.99, P = 0.003), and 
      rye, RR 0.989 (95% CI: 0.982, 0.997, P = 0.006). The RR for gross domestic 
      product on celiac disease prevalence was 1.009 (95% CI: 1.005, 1.014, P < 0.001). 
      The RR for HLA-DQ2 was 0.982 (95% CI: 0.979, 0.986, P < 0.001), and that for 
      HLA-DQ8 was 0.957 (95% CI: 0.950, 0.964, P < 0.001). In this geo-epidemiologic 
      study, gluten-containing grain availability showed mixed associations with celiac 
      disease prevalence.
CI  - (c) 2023 Journal of Gastroenterology and Hepatology Foundation and John Wiley & 
      Sons Australia, Ltd.
FAU - Jansson-Knodell, Claire L
AU  - Jansson-Knodell CL
AUID- ORCID: 0000-0001-6148-4203
AD  - Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and 
      Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Celdir, Melis G
AU  - Celdir MG
AD  - Department of Gastroenterology, University of Iowa Hospitals and Clinics, Iowa 
      City, Iowa, USA.
FAU - Hujoel, Isabel A
AU  - Hujoel IA
AD  - Department of Gastroenterology, University of Washington, Seattle, Washington, 
      USA.
FAU - Lyu, Ruishen
AU  - Lyu R
AD  - Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, 
      USA.
FAU - Gardinier, David
AU  - Gardinier D
AD  - Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and 
      Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Weekley, Kendra
AU  - Weekley K
AD  - Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and 
      Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
FAU - Prokop, Larry J
AU  - Prokop LJ
AD  - Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota, USA.
FAU - Rubio-Tapia, Alberto
AU  - Rubio-Tapia A
AD  - Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and 
      Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
LA  - eng
GR  - AGA2022-13-07/AGA Research Foundation/
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20230618
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Humans
MH  - *Celiac Disease/epidemiology/etiology/diagnosis
MH  - Glutens/adverse effects
MH  - Genetic Predisposition to Disease
MH  - Biopsy
OTO - NOTNLM
OT  - biopsy
OT  - epidemiology
OT  - global
OT  - grain
OT  - seropositive
EDAT- 2023/06/19 00:42
MHDA- 2023/10/23 00:42
CRDT- 2023/06/18 23:35
PHST- 2023/05/04 00:00 [revised]
PHST- 2023/03/10 00:00 [received]
PHST- 2023/05/31 00:00 [accepted]
PHST- 2023/10/23 00:42 [medline]
PHST- 2023/06/19 00:42 [pubmed]
PHST- 2023/06/18 23:35 [entrez]
AID - 10.1111/jgh.16260 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2023 Oct;38(10):1695-1709. doi: 10.1111/jgh.16260. Epub 
      2023 Jun 18.