PMID- 37332095
OWN - NLM
STAT- MEDLINE
DCOM- 20240306
LR  - 20240314
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
VI  - 36
IP  - 3
DP  - 2024 Mar
TI  - Long-term efficacy of antireflux mucosectomy in patients with refractory 
      gastroesophageal reflux disease.
PG  - 305-313
LID - 10.1111/den.14617 [doi]
AB  - OBJECTIVES: Minimally invasive treatments have been applied for gastroesophageal 
      reflux disease (GERD), but the long-term results are controversial. Antireflux 
      mucosectomy (ARMS) is a simple endoscopic procedure that does not require the 
      insertion of a foreign body. We provide the first report on the long-term results 
      of ARMS. METHODS: This was a single-center, single-arm trial, prospective study 
      of 88 patients with proton pump inhibitor (PPI)-refractory GERD who underwent 
      ARMS between June 2012 and June 2017. Primary outcomes were the rates of 
      long-term effectiveness and PPI discontinuation. Secondary outcomes were to 
      compare patients' preoperative background characteristics, questionnaire, and 
      multichannel intraluminal impedance and pH monitoring data to examine the 
      predictive factors of ARMS. The clinical course was reviewed, including the need 
      for additional treatment after ARMS. RESULTS: Antireflux mucosectomy produced a 
      long-term effect in 68.3% of the patients, and PPI could be discontinued in 42% 
      of patients. There were significant differences in age, intensity of preoperative 
      symptoms, and acid-related indicators. Forty-five percent (27/60) had reflux 
      hypersensitivity and ARMS provided long-term effectiveness in 81% of 
      these patients. There was no significant difference in subjective symptom 
      assessment between those with short-term and long-term efficacy. Additional 
      treatment was administered in 23% (14/60) and scheduled at 1-2 years' follow-up. 
      CONCLUSIONS: Antireflux mucosectomy showed long-term efficacy, and many of the 
      cases with short-term effects were able to maintain them. In addition, ARMS is 
      also effective in patients with reflux hypersensitivity, and provides a treatment 
      option that bridges the gap between surgical and medical treatment.
CI  - (c) 2023 Japan Gastroenterological Endoscopy Society.
FAU - Sumi, Kazuya
AU  - Sumi K
AUID- ORCID: 0000-0002-5484-8504
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Inoue, Haruhiro
AU  - Inoue H
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Ando, Ryohei
AU  - Ando R
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Fujiyoshi, Mary Raina Angeli
AU  - Fujiyoshi MRA
AUID- ORCID: 0000-0002-5860-9164
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Fujiyoshi, Yusuke
AU  - Fujiyoshi Y
AUID- ORCID: 0000-0002-5893-6552
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Tanabe, Mayo
AU  - Tanabe M
AUID- ORCID: 0000-0001-6126-5684
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Shimamura, Yuto
AU  - Shimamura Y
AUID- ORCID: 0000-0003-4107-9264
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
FAU - Onimaru, Manabu
AU  - Onimaru M
AD  - Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20230713
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - Endoscopy
MH  - *Gastroesophageal Reflux/diagnosis
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - antireflux mucosectomy
OT  - gastroesophageal reflux disease
OT  - proton pump inhibitor
OT  - reflux hypersensitivity
EDAT- 2023/06/19 00:42
MHDA- 2024/03/06 06:43
CRDT- 2023/06/18 23:42
PHST- 2023/04/03 00:00 [received]
PHST- 2023/06/15 00:00 [accepted]
PHST- 2024/03/06 06:43 [medline]
PHST- 2023/06/19 00:42 [pubmed]
PHST- 2023/06/18 23:42 [entrez]
AID - 10.1111/den.14617 [doi]
PST - ppublish
SO  - Dig Endosc. 2024 Mar;36(3):305-313. doi: 10.1111/den.14617. Epub 2023 Jul 13.