PMID- 37333060
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231106
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2023
DP  - 2023
TI  - Comparison of Biological Properties and Clinical Application of Mesenchymal Stem 
      Cells from the Mesoderm and Ectoderm.
PG  - 4547875
LID - 10.1155/2023/4547875 [doi]
LID - 4547875
AB  - Since the discovery of mesenchymal stem cells (MSCs) in the 1970s, they have been 
      widely used in the treatment of a variety of diseases because of their wide 
      sources, strong differentiation potential, rapid expansion in vitro, low 
      immunogenicity, and so on. At present, most of the related research is on 
      mesoderm-derived MSCs (M-MSCs) such as bone marrow MSCs and adipose-derived MSCs. 
      As a type of MSC, ectoderm-derived MSCs (E-MSCs) have a stronger potential for 
      self-renewal, multidirectional differentiation, and immunomodulation and have 
      more advantages than M-MSCs in some specific conditions. This paper analyzes the 
      relevant research development of E-MSCs compared with that of M-MSCs; summarizes 
      the extraction, discrimination and culture, biological characteristics, and 
      clinical application of E-MSCs; and discusses the application prospects of 
      E-MSCs. This summary provides a theoretical basis for the better application of 
      MSCs from both ectoderm and mesoderm in the future.
CI  - Copyright (c) 2023 Zhenning Wang et al.
FAU - Wang, Zhenning
AU  - Wang Z
AUID- ORCID: 0009-0004-2587-9653
AD  - Medical School of Chinese PLA, Beijing 100853, China.
AD  - Department of Orthodontics, The First Medical Center, Chinese PLA General 
      Hospital, Beijing 100853, China.
FAU - Huang, Meng
AU  - Huang M
AD  - Medical School of Chinese PLA, Beijing 100853, China.
AD  - Department of Orthodontics, The First Medical Center, Chinese PLA General 
      Hospital, Beijing 100853, China.
FAU - Zhang, Yu
AU  - Zhang Y
AUID- ORCID: 0000-0001-7466-3227
AD  - Medical School of Chinese PLA, Beijing 100853, China.
AD  - Department of Orthodontics, The First Medical Center, Chinese PLA General 
      Hospital, Beijing 100853, China.
FAU - Jiang, Xiaoxia
AU  - Jiang X
AUID- ORCID: 0000-0003-1401-9653
AD  - Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
FAU - Xu, Lulu
AU  - Xu L
AUID- ORCID: 0000-0003-1082-1067
AD  - Department of Orthodontics, The First Medical Center, Chinese PLA General 
      Hospital, Beijing 100853, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230610
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC10276766
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/06/19 06:42
MHDA- 2023/06/19 06:43
PMCR- 2023/06/10
CRDT- 2023/06/19 02:44
PHST- 2022/05/10 00:00 [received]
PHST- 2023/05/04 00:00 [revised]
PHST- 2023/05/23 00:00 [accepted]
PHST- 2023/06/19 06:43 [medline]
PHST- 2023/06/19 06:42 [pubmed]
PHST- 2023/06/19 02:44 [entrez]
PHST- 2023/06/10 00:00 [pmc-release]
AID - 10.1155/2023/4547875 [doi]
PST - epublish
SO  - Stem Cells Int. 2023 Jun 10;2023:4547875. doi: 10.1155/2023/4547875. eCollection 
      2023.