PMID- 3733313
OWN - NLM
STAT- MEDLINE
DCOM- 19860917
LR  - 20131121
IS  - 0172-4622 (Print)
IS  - 0172-4622 (Linking)
VI  - 7
IP  - 3
DP  - 1986 Jun
TI  - Inheritance of human skeletal muscle and anaerobic capacity adaptation to 
      high-intensity intermittent training.
PG  - 167-71
AB  - The role of heredity in the response of maximal anaerobic capacities and skeletal 
      muscle histochemical and biochemical characteristics to a 15-week cycle ergometer 
      training program involving both continuous and interval work patterns was 
      investigated in 14 pairs of monozygotic twins. The training program consisted 
      mainly of series of ergocycle supramaximal exercises lasting from 15 s to 90 s 
      and performed 4 and 5 times a week. The subjects were submitted to 10 s and 90 s 
      all-out ergocycle tests to estimate maximal anaerobic alactacid (AAC) and 
      lactacid (ALC) capacities, respectively. Muscle fiber types and creatine kinase 
      (CK), hexokinase (HK), phosphofructokinase (PFK), lactate dehydrogenase (LDH), 
      malate dehydrogenase (MDH), 3-hydroxyacyl CoA dehydrogenase (HADH), and 
      oxoglutarate dehydrogenase (OGDH) activities were determined in a biopsy from the 
      vastus lateralis. Training increased AAC, ALC, fiber type I proportion, MDH, 
      HADH, and OGDH (P less than 0.05) and decreased fiber type IIb proportion and the 
      PFK/OGDH ratio. No significant change was observed for CK, HK, PFK, and LDH. 
      Large interindividual differences in the response to training were observed for 
      all variables. However, intraclass correlations indicated that the extent of the 
      response of ALC and CK, HK, LDH, MDH, and OGDH activities and of the PFK/OGDH 
      activity ratio to training were significantly similar within pairs of twins. 
      Although the role of heredity appeared absent for the changes in fiber type 
      proportions and in anaerobic alactacid capacity, the present results suggest that 
      the response of anaerobic lactacid capacity and most enzyme activities to 
      high-intensity intermittent training is significantly determined by the genotype.
FAU - Simoneau, J A
AU  - Simoneau JA
FAU - Lortie, G
AU  - Lortie G
FAU - Boulay, M R
AU  - Boulay MR
FAU - Marcotte, M
AU  - Marcotte M
FAU - Thibault, M C
AU  - Thibault MC
FAU - Bouchard, C
AU  - Bouchard C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Lactates)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Anaerobiosis
MH  - Biopsy
MH  - Female
MH  - *Genetics, Medical
MH  - Genotype
MH  - Histocytochemistry
MH  - Humans
MH  - Lactates/metabolism
MH  - Lactic Acid
MH  - Male
MH  - Muscles/*enzymology
MH  - *Physical Education and Training
MH  - Physical Exertion
MH  - Time Factors
MH  - Twins, Monozygotic
EDAT- 1986/06/01 00:00
MHDA- 1986/06/01 00:01
CRDT- 1986/06/01 00:00
PHST- 1986/06/01 00:00 [pubmed]
PHST- 1986/06/01 00:01 [medline]
PHST- 1986/06/01 00:00 [entrez]
AID - 10.1055/s-2008-1025756 [doi]
PST - ppublish
SO  - Int J Sports Med. 1986 Jun;7(3):167-71. doi: 10.1055/s-2008-1025756.