PMID- 37335106
OWN - NLM
STAT- Publisher
LR  - 20230619
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
DP  - 2023 Jun 19
TI  - Crosstalk between dietary pomegranate and gut microbiota: evidence of health 
      benefits.
PG  - 1-27
LID - 10.1080/10408398.2023.2219763 [doi]
AB  - Gut microbiota (GM) is an invisible organ that plays an important role in human 
      health. Increasing evidence suggests that polyphenols in pomegranate 
      (punicalagin, PU) could serve as prebiotics to modulate the composition and 
      function of GM. In turn, GM transform PU into bioactive metabolites such as 
      ellagic acid (EA) and urolithin (Uro). In this review, the interplay between 
      pomegranate and GM is thoroughly described by unveiling a dialog in which both 
      actors seem to affect each other's roles. In a first dialog, the influence of 
      bioactive compounds from pomegranate on GM is described. The second act shows how 
      the GM biotransform pomegranate phenolics into Uro. Finally, the health benefits 
      of Uro and that related molecular mechanism are summarized and discussed. Intake 
      of pomegranate promotes beneficial bacteria in GM (e.g. Lactobacillus spp., 
      Bifidobacterium spp.) while reducing the growth of harmful bacteria (e.g. 
      Bacteroides fragilis group, Clostridia). Akkermansia muciniphila, and 
      Gordonibacter spp., among others, biotransform PU and EA into Uro. Uro 
      contributes to strengthening intestinal barrier and reducing inflammatory 
      processes. Yet, Uro production varies greatly among individuals and depend on GM 
      composition. Uro-producing bacteria and precise metabolic pathways need to be 
      further elucidated therefore contributing to personalized and precision 
      nutrition.
FAU - Yin, Yantao
AU  - Yin Y
AD  - Key Laboratory of Meat Processing and Quality Control, College of Food Science 
      and Technology, Nanjing Agricultural University, Nanjing, China.
AD  - TECAL Research Group, IPROCAR Research Institute, Universidad de Extremadura, 
      Caceres, Spain.
FAU - Martinez, Remigio
AU  - Martinez R
AD  - TECAL Research Group, IPROCAR Research Institute, Universidad de Extremadura, 
      Caceres, Spain.
AD  - Infectious Diseases Unit. Animal Health Department, University of Extremadura, 
      Caceres, Spain.
AD  - Departamento de Sanidad Animal, Grupo de Investigacion en Sanidad Animal y 
      Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, University of 
      Cordoba, Cordoba, Spain.
FAU - Zhang, Wangang
AU  - Zhang W
AD  - Key Laboratory of Meat Processing and Quality Control, College of Food Science 
      and Technology, Nanjing Agricultural University, Nanjing, China.
FAU - Estevez, Mario
AU  - Estevez M
AD  - TECAL Research Group, IPROCAR Research Institute, Universidad de Extremadura, 
      Caceres, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230619
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
SB  - IM
OAB - Gut microbiota plays a critical role in maintaining host health.Pomegranate is 
      rich in bioactive components.Consumption of pomegranate positively modulates gut 
      microbiota.Gut microbiota can transform ellagitannins in pomegranate into 
      urolithin.Urolithin has high bioavailability and multiple health benefits.
OABL- eng
OTO - NOTNLM
OT  - Gut microbiota
OT  - health benefit
OT  - pomegranate
OT  - urolithin
EDAT- 2023/06/19 13:08
MHDA- 2023/06/19 13:08
CRDT- 2023/06/19 09:03
PHST- 2023/06/19 13:08 [medline]
PHST- 2023/06/19 13:08 [pubmed]
PHST- 2023/06/19 09:03 [entrez]
AID - 10.1080/10408398.2023.2219763 [doi]
PST - aheadofprint
SO  - Crit Rev Food Sci Nutr. 2023 Jun 19:1-27. doi: 10.1080/10408398.2023.2219763.