PMID- 37335239
OWN - NLM
STAT- MEDLINE
DCOM- 20230714
LR  - 20230924
IS  - 1473-5830 (Electronic)
IS  - 0954-6928 (Linking)
VI  - 34
IP  - 5
DP  - 2023 Aug 1
TI  - Effects of olive oil and flaxseed consumption in a healthy diet on endothelial 
      function, plasma lipids and inflammatory factors of patients with coronary heart 
      disease: a randomized clinical trial.
PG  - 332-340
LID - 10.1097/MCA.0000000000001259 [doi]
AB  - OBJECTIVES: A healthy lifestyle, including a healthy diet has been associated 
      with an improvement in cardiovascular risk factors. The aim of the present study 
      was to assess the effect of olive oil and flaxseed consumption as part of a 
      healthy diet on endothelial function, plasma inflammatory factors, and lipid 
      profile in patients with coronary heart disease (CHD). METHOD: This randomized 
      nonblinded trial was performed on CHD patients. In the control group, 
      participants received general heart-healthy dietary recommendations while in the 
      intervention group, in addition to these recommendations, the participants 
      consumed 25 ml of olive oil and 30 g of flaxseeds daily for 3 months. At baseline 
      and after 3 months, changes in brachial flow-mediated dilation (FMD), plasma 
      asymmetric dimethyl arginine, interleukin-6 (IL-6), IL-10, high-sensitivity 
      C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), monocyte 
      chemoattractant protein-1 (MCP-1), and lipids and lipoproteins were measured. 
      RESULTS: A total of 50 patients finished the trial ( n  = 24 in the intervention 
      and n  = 26 in the control groups). Compared to the control group, consumption of 
      flaxseed and olive oil significantly improved brachial artery FMD%, and reduced 
      plasma IL-6, TNF-alpha, MCP-1, total cholesterol, and tended to reduce hs-CRP, and 
      non-HDL-cholesterol but the concentration of other study indices were not 
      different between the two groups. CONCLUSION: Inclusion of olive oil and flaxseed 
      in the diet of CHD patients may contribute to secondary prevention by improving 
      endothelial function and plasma inflammatory factors.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Khandouzi, Nafiseh
AU  - Khandouzi N
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, Shahid Beheshti University of Medical Sciences.
FAU - Zahedmehr, Ali
AU  - Zahedmehr A
AD  - Cardiovascular Intervention Research Center.
FAU - Asadian, Sanaz
AU  - Asadian S
AD  - Department of Radiology, Rajaie Cardiovascular, Medical & Research Center, Iran 
      University of Medical Sciences, Tehran, Iran.
FAU - Nasrollahzadeh, Javad
AU  - Nasrollahzadeh J
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, Shahid Beheshti University of Medical Sciences.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230605
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Olive Oil)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Humans
MH  - Olive Oil
MH  - *Flax/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Diet, Healthy
MH  - *Coronary Disease/prevention & control
MH  - Cholesterol
EDAT- 2023/06/19 13:08
MHDA- 2023/07/14 13:06
CRDT- 2023/06/19 10:06
PHST- 2023/07/14 13:06 [medline]
PHST- 2023/06/19 13:08 [pubmed]
PHST- 2023/06/19 10:06 [entrez]
AID - 00019501-202308000-00006 [pii]
AID - 10.1097/MCA.0000000000001259 [doi]
PST - ppublish
SO  - Coron Artery Dis. 2023 Aug 1;34(5):332-340. doi: 10.1097/MCA.0000000000001259. 
      Epub 2023 Jun 5.