PMID- 37335848
OWN - NLM
STAT- MEDLINE
DCOM- 20231205
LR  - 20231216
IS  - 2327-6924 (Electronic)
IS  - 2327-6886 (Linking)
VI  - 35
IP  - 12
DP  - 2023 Dec 1
TI  - Exploring novel approaches to food allergy management.
PG  - 843-852
LID - 10.1097/JXX.0000000000000905 [doi]
AB  - Nurse practitioners are likely to encounter pediatric and adult patients with 
      symptoms of food allergy who need an accurate diagnosis, emergency treatment 
      plans, and options for management. The pathophysiology of immunoglobulin E 
      (IgE)-mediated food allergy, current and emerging diagnostics, treatment, and 
      emergency management is briefly reviewed, and promising new and potential future 
      treatment options are discussed. Currently, Food and Drug Administration-approved 
      oral immunotherapy (OIT) treatment for peanut allergy, but clinical trials are 
      underway to explore multiple-allergen OIT and alternate routes for IT such as 
      sublingual and epicutaneous. Treatments that modulate the immune system are also 
      potential treatments for food allergies (FAs), including biologic agents. 
      Omalizumab, an anti-IgE therapy, dupilumab, an interleukin-4Ra receptor 
      monoclonal antibody, and etokimab, an anti-IL-33, are all being studied for the 
      treatment of food allergy. There is hope that these novel therapies for FAs will 
      be a viable option translated to the practice setting in the near future, so that 
      strict avoidance is not the only treatment plan for FAs. Nurse practitioners can 
      support their patients with FAs and their families by keeping abreast of progress 
      in food allergy research and assisting patients to consider novel treatment 
      options, when appropriate, using shared decision making.
CI  - Copyright (c) 2023 American Association of Nurse Practitioners.
FAU - Howard-Ruben, Josie
AU  - Howard-Ruben J
AUID- ORCID: 0000-0001-5665-3527
AD  - Department of Adult Health and Gerontological Nursing, Rush University College of 
      Nursing, Chicago, Illinois.
FAU - Doucette, Julianne
AU  - Doucette J
AUID- ORCID: 0000-0002-6999-0327
AD  - Department of Women, Children, and Family Nursing, Rush University College of 
      Nursing, Chicago, Illinois.
LA  - eng
PT  - Journal Article
DEP - 20231201
PL  - United States
TA  - J Am Assoc Nurse Pract
JT  - Journal of the American Association of Nurse Practitioners
JID - 101600770
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
MH  - United States
MH  - Humans
MH  - Child
MH  - *Food Hypersensitivity/drug therapy
MH  - Allergens/therapeutic use
MH  - Desensitization, Immunologic
MH  - Administration, Oral
MH  - Immunoglobulin E
COIS- Competing interests: The authors report no conflicts of interest.
EDAT- 2023/06/19 19:12
MHDA- 2023/12/05 12:42
CRDT- 2023/06/19 14:32
PHST- 2023/02/23 00:00 [received]
PHST- 2023/05/10 00:00 [accepted]
PHST- 2023/12/05 12:42 [medline]
PHST- 2023/06/19 19:12 [pubmed]
PHST- 2023/06/19 14:32 [entrez]
AID - 01741002-990000000-00135 [pii]
AID - 10.1097/JXX.0000000000000905 [doi]
PST - epublish
SO  - J Am Assoc Nurse Pract. 2023 Dec 1;35(12):843-852. doi: 
      10.1097/JXX.0000000000000905.