PMID- 37336106 OWN - NLM STAT- MEDLINE DCOM- 20231023 LR - 20231030 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 458 DP - 2023 Sep 15 TI - Environmental pollutant pre- and polyfluoroalkyl substances are associated with electrocardiogram parameters disorder in adults. PG - 131832 LID - S0304-3894(23)01115-9 [pii] LID - 10.1016/j.jhazmat.2023.131832 [doi] AB - Environmental pollutants exposure might disrupt cardiac function, but evidence about the associations of per- and polyfluoroalkyl substances (PFASs) exposure and cardiac conduction system remains sparse. To explore the associations between serum PFASs exposure and electrocardiogram (ECG) parameters changes in adults, we recruited 1229 participants (mean age: 55.1 years) from communities of Guangzhou, China. 13 serum PFASs with detection rate > 85% were analyzed finally. We selected 6 ECG parameters [heart rate (HR), PR interval, QRS duration, Bazett heart rate-corrected QT interval (QTc), QRS electric axis and RV5 + SV1 voltage] as outcomes. Generalized linear models (GLMs) and Bayesian kernel machine regression (BKMR) model were conducted to explore the associations of individual and joint PFASs exposure and ECG parameters changes, respectively. We detected significant associations of PFASs exposure with decreased HR, QRS duration, but with increased PR interval. For example, at the 95th percentile of 6:2 Cl-PFESA, HR and QRS duration were - 6.98 [95% confidence interval (CI): - 9.07, - 4.90] and - 6.54(95% CI: -9.05, -4.03) lower, but PR interval was 7.35 (95% CI: 3.52, 11.17) longer than those at the 25th percentile. Similarly, significant joint associations were observed in HR, PR interval and QRS duration when analyzed by BKMR model. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Fan, Yuan-Yuan AU - Fan YY AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Chu, Chu AU - Chu C AD - Guangdong Cardiovascular Institute, Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. FAU - Zhang, Yun-Ting AU - Zhang YT AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Zhao, Kun AU - Zhao K AD - Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. FAU - Liang, Li-Xia AU - Liang LX AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Huang, Jing-Wen AU - Huang JW AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Zhou, Jia-Xin AU - Zhou JX AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Guo, Li-Hao AU - Guo LH AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Wu, Lu-Yin AU - Wu LY AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Lin, Li-Zi AU - Lin LZ AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Liu, Ru-Qing AU - Liu RQ AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. FAU - Feng, Wenru AU - Feng W AD - Department of Environmental Health, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China. Electronic address: gzcdc_fengwr@gz.gov.cn. FAU - Dong, Guang-Hui AU - Dong GH AD - Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn. FAU - Zhao, Xiaomiao AU - Zhao X AD - Department of Reproductive Medicine, Department of Obstetrics and Gynecology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address: zhaoxmiao@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230615 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - Humans MH - Adult MH - Middle Aged MH - *Environmental Pollutants MH - Bayes Theorem MH - Environmental Exposure MH - Electrocardiography MH - *Fluorocarbons/toxicity OTO - NOTNLM OT - Electrocardiogram (ECG) OT - Heart rate (HR) OT - PFASs OT - PR interval OT - QRS duration COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/06/20 01:09 MHDA- 2023/10/23 00:44 CRDT- 2023/06/19 18:05 PHST- 2023/01/26 00:00 [received] PHST- 2023/05/14 00:00 [revised] PHST- 2023/06/09 00:00 [accepted] PHST- 2023/10/23 00:44 [medline] PHST- 2023/06/20 01:09 [pubmed] PHST- 2023/06/19 18:05 [entrez] AID - S0304-3894(23)01115-9 [pii] AID - 10.1016/j.jhazmat.2023.131832 [doi] PST - ppublish SO - J Hazard Mater. 2023 Sep 15;458:131832. doi: 10.1016/j.jhazmat.2023.131832. Epub 2023 Jun 15.