PMID- 37336521
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230705
IS  - 2093-2278 (Print)
IS  - 2093-2286 (Electronic)
IS  - 2093-2278 (Linking)
VI  - 53
IP  - 3
DP  - 2023 Jun
TI  - Sinus augmentation with poly(epsilon)caprolactone-beta tricalcium phosphate scaffolds, 
      mesenchymal stem cells and platelet rich plasma for one-stage dental implantation 
      in minipigs.
PG  - 218-232
LID - 10.5051/jpis.2300660033 [doi]
AB  - PURPOSE: This study evaluated the efficacy of a tube-shaped poly(epsilon) caprolactone 
      - beta tricalcium phosphate (PCL-TCP) scaffold with the incorporation of human 
      umbilical cord-derived mesenchymal stem cells (hUCMSCs) and platelet-rich plasma 
      (PRP) for bone regeneration in the procedure of single-stage sinus augmentation 
      and dental implantation in minipigs. METHODS: Implants were placed in the 
      bilateral sides of the maxillary sinuses of 5 minipigs and allocated to a 
      PCL-TCP+hUCMSCs+PRP group (n=5), a PCL-TCP+PRP group (n=5), and a PCL-TCP-only 
      group (n=6). After 12 weeks, bone regeneration was evaluated with soft X-rays, 
      micro-computed tomography, fluorescence microscopy, and histomorphometric 
      analysis. RESULTS: Four implants failed (2 each in the PCL-TCP+hUCMSCs+PRP and 
      PCL-TCP+hUCMSC groups). An analysis of the grayscale levels and bone-implant 
      contact ratio showed significantly higher mean values in the PCL-TCP+hUCMSCs+PRP 
      than in the PCL-TCP group (P=0.045 and P=0.016, respectively). In 
      fluoromicroscopic images, new bone formation around the outer surfaces of the 
      scaffolds was observed in the PCL-TCP+hUCMSCs+PRP group, suggesting a tenting 
      effect of the specially designed scaffolds. Bone regeneration at the 
      scaffold-implant interfaces was observed in all 3 groups. CONCLUSIONS: Using a 
      tube-shaped, honeycombed PCL-TCP scaffold with hUCMSCs and PRP may serve to 
      enhance bone formation and dental implants' osseointegration in the procedure of 
      simultaneous sinus lifting and dental implantation.
CI  - Copyright (c) 2023. Korean Academy of Periodontology.
FAU - Nam, Jeong-Hun
AU  - Nam JH
AUID- ORCID: 0000-0003-3957-0476
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National 
      University, Seoul, Korea.
FAU - Almansoori, Akram Abdo
AU  - Almansoori AA
AUID- ORCID: 0000-0001-7134-9195
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National 
      University, Seoul, Korea.
AD  - Dental Life Science Research Institute, Innovation Research & Support Center for 
      Dental Science, Seoul National University Dental Hospital, Seoul, Korea.
FAU - Kwon, Oh-Jun
AU  - Kwon OJ
AUID- ORCID: 0000-0002-0457-6539
AD  - Department of Oral & Maxillofacial Surgery, School of Dentistry, Seoul National 
      University, Seoul, Korea.
FAU - Seo, Young-Kwon
AU  - Seo YK
AUID- ORCID: 0000-0001-7533-9605
AD  - Department of Chemical and Biochemical Engineering, College of Engineering, 
      Dongkuk University, Seoul, Korea.
FAU - Kim, Bongju
AU  - Kim B
AUID- ORCID: 0000-0001-7309-5977
AD  - Dental Life Science Research Institute, Innovation Research & Support Center for 
      Dental Science, Seoul National University Dental Hospital, Seoul, Korea.
FAU - Kim, Young-Kyun
AU  - Kim YK
AUID- ORCID: 0000-0002-7268-3870
AD  - Department of Oral & Maxillofacial Surgery, Section of Dentistry, Seoul National 
      University Bundang Hospital, Seongnam, Korea.
FAU - Lee, Jong-Ho
AU  - Lee JH
AUID- ORCID: 0000-0002-8843-545X
AD  - Dental Life Science Research Institute, Innovation Research & Support Center for 
      Dental Science, Seoul National University Dental Hospital, Seoul, Korea.
AD  - Oral Oncology Clinic, National Cancer Center, Ilsan, Korea.
FAU - Pang, KangMi
AU  - Pang K
AUID- ORCID: 0000-0001-9148-9080
AD  - Department of Oral & Maxillofacial Surgery, Seoul National University Gwanak 
      Dental Hospital, Seoul, Korea. pkm81@snu.ac.kr.
LA  - eng
GR  - HI20C2114/Korea Health Industry Development Institute/Republic of Korea
PT  - Journal Article
DEP - 20230512
PL  - Korea (South)
TA  - J Periodontal Implant Sci
JT  - Journal of periodontal & implant science
JID - 101526931
PMC - PMC10315254
OTO - NOTNLM
OT  - Dental implants
OT  - Platelet-rich plasma
OT  - Sinus floor augmentation
OT  - Stem cells
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2023/06/20 01:09
MHDA- 2023/06/20 01:10
PMCR- 2023/06/01
CRDT- 2023/06/19 20:12
PHST- 2023/01/13 00:00 [received]
PHST- 2023/03/10 00:00 [revised]
PHST- 2023/04/03 00:00 [accepted]
PHST- 2023/06/20 01:10 [medline]
PHST- 2023/06/20 01:09 [pubmed]
PHST- 2023/06/19 20:12 [entrez]
PHST- 2023/06/01 00:00 [pmc-release]
AID - 53.e16 [pii]
AID - 10.5051/jpis.2300660033 [doi]
PST - ppublish
SO  - J Periodontal Implant Sci. 2023 Jun;53(3):218-232. doi: 10.5051/jpis.2300660033. 
      Epub 2023 May 12.