PMID- 37337143
OWN - NLM
STAT- MEDLINE
DCOM- 20230621
LR  - 20230701
IS  - 1471-2180 (Electronic)
IS  - 1471-2180 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Jun 19
TI  - Meta-analysis of the effects of proton pump inhibitors on the human gut 
      microbiota.
PG  - 171
LID - 10.1186/s12866-023-02895-w [doi]
LID - 171
AB  - Mounting evidence has linked changes in human gut microbiota to proton pump 
      inhibitor (PPI) use. Accordingly, multiple studies have analyzed the gut 
      microbiomes of PPI users, but PPI-microbe interactions are still understudied. 
      Here, we performed a meta-analysis of four studies with available 16S rRNA gene 
      amplicon sequencing data to uncover the potential changes in human gut microbes 
      among PPI users. Despite some differences, we found common features of the 
      PPI-specific microbiota, including a decrease in the Shannon diversity index and 
      the depletion of bacteria from the Ruminococcaceae and Lachnospiraceae families, 
      which are crucial short-chain fatty acid-producers. Through training based on 
      multiple studies, using a random forest classification model, we further verified 
      the representativeness of the six screened gut microbial genera and 20 functional 
      genes as PPI-related biomarkers, with AUC values of 0.748 and 0.879, 
      respectively. Functional analysis of the PPI-associated 16S rRNA microbiome 
      revealed enriched carbohydrate- and energy-associated genes, mostly encoding 
      fructose-1,6-bisphosphatase and pyruvate dehydrogenase, among others. In this 
      study, we have demonstrated alterations in bacterial abundance and functional 
      metabolic potential related to PPI use, as a basis for future studies on 
      PPI-induced adverse effects.
CI  - (c) 2023. The Author(s).
FAU - Zhang, Jiayi
AU  - Zhang J
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 
      Jiangsu, 214122, People's Republic of China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi, 214122, 
      Jiangsu, China.
FAU - Zhang, Chengcheng
AU  - Zhang C
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 
      Jiangsu, 214122, People's Republic of China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi, 214122, 
      Jiangsu, China.
FAU - Zhang, Qingsong
AU  - Zhang Q
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 
      Jiangsu, 214122, People's Republic of China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi, 214122, 
      Jiangsu, China.
FAU - Yu, Leilei
AU  - Yu L
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 
      Jiangsu, 214122, People's Republic of China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi, 214122, 
      Jiangsu, China.
FAU - Chen, Wei
AU  - Chen W
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 
      Jiangsu, 214122, People's Republic of China.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi, 214122, 
      Jiangsu, China.
FAU - Xue, Yuzheng
AU  - Xue Y
AD  - Department of Gastroenterology, Affiliated Hospital of Jiangnan University, 
      Jiangsu Province, Wuxi, China. xueyz001@163.com.
FAU - Zhai, Qixiao
AU  - Zhai Q
AD  - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 
      Jiangsu, 214122, People's Republic of China. zhaiqixiao@sina.com.
AD  - School of Food Science and Technology, Jiangnan University, Wuxi, 214122, 
      Jiangsu, China. zhaiqixiao@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20230619
PL  - England
TA  - BMC Microbiol
JT  - BMC microbiology
JID - 100966981
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (RNA, Ribosomal, 16S)
SB  - IM
MH  - Humans
MH  - Proton Pump Inhibitors/pharmacology
MH  - *Gastrointestinal Microbiome/genetics
MH  - RNA, Ribosomal, 16S/genetics
MH  - Feces/microbiology
MH  - *Microbiota
MH  - Bacteria/genetics
MH  - Clostridiales/genetics
PMC - PMC10278323
OTO - NOTNLM
OT  - Biomarkers
OT  - Gut microbiota
OT  - Meta-analysis
OT  - Proton pump inhibitors
OT  - Supervised learning technique
COIS- The authors declare no competing interests.
EDAT- 2023/06/20 01:09
MHDA- 2023/06/21 06:42
PMCR- 2023/06/19
CRDT- 2023/06/19 23:29
PHST- 2023/01/27 00:00 [received]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/06/21 06:42 [medline]
PHST- 2023/06/20 01:09 [pubmed]
PHST- 2023/06/19 23:29 [entrez]
PHST- 2023/06/19 00:00 [pmc-release]
AID - 10.1186/s12866-023-02895-w [pii]
AID - 2895 [pii]
AID - 10.1186/s12866-023-02895-w [doi]
PST - epublish
SO  - BMC Microbiol. 2023 Jun 19;23(1):171. doi: 10.1186/s12866-023-02895-w.