PMID- 37337740
OWN - NLM
STAT- Publisher
LR - 20230620
IS - 2724-6116 (Electronic)
IS - 2724-6116 (Linking)
DP - 2023 Jun 20
TI - Results of semaglutide in patients older than 70 years, a real-world study of
efficacy and safety.
LID - 10.23736/S2724-6507.23.03985-4 [doi]
AB - BACKGROUND: The aim of this study is to investigate the use of once-weekly
semaglutide in a real population of patients with type 2 diabetes mellitus (T2DM)
over 70 years in two Spanish hospitals. METHODS: An observational, retrospective,
and multicenter clinical study was designed. It included 60 patients with T2DM,
with a mean age of 76.5 years, 63.3% women, and a mean of 15.5 years of evolution
of T2DM, all managed in the outpatient clinical setting. The primary endpoint was
the change in HbA1c from baseline to the end of the study. The
secondary endpoints included changes in body weight and the proportion of
patients achieving HbA1c <7.0% and body weight loss >5%. RESULTS:
After 12 months of follow-up, the reductions in HbA1c were -0.61+/-0.9%
(P<0.0001) in the total cohort. Body weight reductions were -8.2+/-5.3 kg
(P<0.0001). Overall, 67% reached the objective of an HbA1c level of
<7%, and 73% achieved a weight loss of >/=5%. CONCLUSIONS: In routine clinical
practice in Spain, the use of semaglutide once a week was associated with
statistically significant and clinically relevant improvements in
HbA1c and body weight in adults aged over 70 years with T2DM, without
notable adverse effects, which supports real-world use.
FAU - Garcia DE Lucas, Maria D
AU - Garcia DE Lucas MD
AD - Department of Internal Medicine, Costa del Sol Hospital, Marbella, Spain.
FAU - Perez-Belmonte, Luis
AU - Perez-Belmonte L
AD - Department of Internal Medicine, Regional University Hospital and Biomedical
Research Institute, Malaga, Spain.
FAU - Aviles-Bueno, Beatriz
AU - Aviles-Bueno B
AD - Department of Nephrology, Costa del Sol Hospital, Marbella, Spain.
FAU - Jimenez-Millan, Anabel
AU - Jimenez-Millan A
AD - Department of Endocrinology, University Hospital of Puerto Real, Puerto Real,
Spain.
FAU - Rivas Ruiz, Francisco
AU - Rivas Ruiz F
AD - Research Unit, Costa del Sol Hospital, Marbella, Spain.
FAU - Miramontes-Gonzalez, Jose P
AU - Miramontes-Gonzalez JP
AD - Department Internal Medicine, Rio Hortega University Hospital, Valladolid
University, Valladolid, Spain - jpmiramontes@hotmail.com.
LA - eng
PT - Journal Article
DEP - 20230620
PL - Italy
TA - Minerva Endocrinol (Torino)
JT - Minerva endocrinology
JID - 101777342
SB - IM
EDAT- 2023/06/20 06:42
MHDA- 2023/06/20 06:42
CRDT- 2023/06/20 03:37
PHST- 2023/06/20 06:42 [medline]
PHST- 2023/06/20 06:42 [pubmed]
PHST- 2023/06/20 03:37 [entrez]
AID - S2724-6507.23.03985-4 [pii]
AID - 10.23736/S2724-6507.23.03985-4 [doi]
PST - aheadofprint
SO - Minerva Endocrinol (Torino). 2023 Jun 20. doi: 10.23736/S2724-6507.23.03985-4.