PMID- 37340095
OWN - NLM
STAT- MEDLINE
DCOM- 20230726
LR  - 20230726
IS  - 1447-073X (Electronic)
IS  - 1447-073X (Linking)
VI  - 98
IP  - 4
DP  - 2023 Sep
TI  - Clinical anatomy of the precuneus and pathogenesis of the schizophrenia.
PG  - 473-481
LID - 10.1007/s12565-023-00730-w [doi]
AB  - Recent evidence has shown that the precuneus plays a role in the pathogenesis of 
      schizophrenia. The precuneus is a structure of the parietal lobe's medial and 
      posterior cortex, representing a central hub involved in multimodal integration 
      processes. Although neglected for several years, the precuneus is highly complex 
      and crucial for multimodal integration. It has extensive connections with 
      different cerebral areas and is an interface between external stimuli and 
      internal representations. In human evolution, the precuneus has increased in size 
      and complexity, allowing the development of higher cognitive functions, such as 
      visual-spatial ability, mental imagery, episodic memory, and other tasks involved 
      in emotional processing and mentalization. This paper reviews the functions of 
      the precuneus and discusses them concerning the psychopathological aspects of 
      schizophrenia. The different neuronal circuits, such as the default mode network 
      (DMN), in which the precuneus is involved and its alterations in the structure 
      (grey matter) and the disconnection of pathways (white matter) are described.
CI  - (c) 2023. The Author(s), under exclusive licence to Japanese Association of 
      Anatomists.
FAU - Messina, Antonino
AU  - Messina A
AUID- ORCID: 0000-0002-3594-8542
AD  - Department of Clinical and Experimental Medicine, Psychiatry Unit, University of 
      Catania, Catania, Italy. thomessina@gmail.com.
FAU - Cucci, Giuseppe
AU  - Cucci G
AD  - Mental Health Department, Enna, Italy.
FAU - Crescimanno, Caterina
AU  - Crescimanno C
AD  - Faculty of Medicine and Surgery, "Kore" University, Enna, Italy.
FAU - Signorelli, Maria Salvina
AU  - Signorelli MS
AD  - Department of Clinical and Experimental Medicine, Psychiatry Unit, University of 
      Catania, Catania, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230620
PL  - Japan
TA  - Anat Sci Int
JT  - Anatomical science international
JID - 101154140
SB  - IM
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Brain Mapping
MH  - *Schizophrenia/pathology
MH  - Parietal Lobe/pathology/physiology
MH  - Cerebral Cortex
MH  - Neural Pathways/physiology
OTO - NOTNLM
OT  - Default mode network
OT  - Multimodal integration
OT  - Parietal lobe
OT  - Precuneus
OT  - Schizophrenia
EDAT- 2023/06/21 01:07
MHDA- 2023/07/26 06:43
CRDT- 2023/06/20 23:25
PHST- 2023/01/13 00:00 [received]
PHST- 2023/05/12 00:00 [accepted]
PHST- 2023/07/26 06:43 [medline]
PHST- 2023/06/21 01:07 [pubmed]
PHST- 2023/06/20 23:25 [entrez]
AID - 10.1007/s12565-023-00730-w [pii]
AID - 10.1007/s12565-023-00730-w [doi]
PST - ppublish
SO  - Anat Sci Int. 2023 Sep;98(4):473-481. doi: 10.1007/s12565-023-00730-w. Epub 2023 
      Jun 20.