PMID- 37340286
OWN - NLM
STAT- Publisher
LR  - 20230620
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Linking)
DP  - 2023 Jun 20
TI  - Abnormal cerebral blood flow and brain function in type 2 diabetes mellitus.
LID - 10.1007/s12020-023-03342-6 [doi]
AB  - PURPOSE: Type 2 diabetes mellitus (T2DM) lead to impaired cerebral blood 
      perfusion, which leads to changes in brain function and affects the cognitive 
      function of patients. In this study, cerebral blood flow (CBF) was used to 
      evaluate the effect of T2DM on cerebral perfusion, and functional connectivity 
      (FC) analysis was further used to explore whether the FC between the abnormal CBF 
      region and the whole brain was changed. In addition, amplitude of low-frequency 
      fluctuation (ALFF) and degree centrality (DC) were used to investigate the 
      changes in spontaneous activity and connectivity strength of the brain network. 
      METHODS: We recruited 40 T2DM patients and 55 healthy controls (HCs). They 
      underwent 3D-T1WI, rs-fMRI, arterial spin labeling (ASL) sequence scans and a 
      series of cognitive tests. Cognitive test scores and brain imaging indicators 
      were compared between the two groups, and the relationships among laboratory 
      indicators, cognitive test scores, and brain imaging indicators were explored in 
      the T2DM group. RESULTS: Compared to HCs, The CBF values of Calcarine_L and 
      Precuneus_R in the T2DM group were lower. The DC value of Paracentral_Lobule_L 
      and Precuneus_L, and the ALFF value of Hippocampus_L in the T2DM group were 
      higher. In addition, the CBF values of Calcarine_L was negatively correlated with 
      fasting insulin and HOMA_IR. CONCLUSION: This study found that there were regions 
      of cerebral hypoperfusion in T2DM patients, which are associated with insulin 
      resistance. In addition, we found abnormally elevated brain activity and enhanced 
      functional connectivity in T2DM patients, which we speculated was the 
      compensatory mechanism of brain neural activity.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Li, Mingrui
AU  - Li M
AUID- ORCID: 0000-0003-0836-4135
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
AD  - Department of Magnatic Resonance Imaging, Zhanjiang First Hospital of Traditional 
      Chinese Medicine, Zhanjiang, China.
FAU - Li, Yifan
AU  - Li Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Zhao, Kui
AU  - Zhao K
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qin, Chunhong
AU  - Qin C
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Chen, Yuna
AU  - Chen Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Liu, Yujie
AU  - Liu Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China.
FAU - Qiu, Shijun
AU  - Qiu S
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China. qiu-sj@163.com.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China. qiu-sj@163.com.
FAU - Tan, Xin
AU  - Tan X
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China. banzi00@126.com.
FAU - Liang, Yi
AU  - Liang Y
AD  - First Clinical Medical College, Guangzhou University of Chinese Medicine, 
      Guangzhou, China. lysogood@126.com.
AD  - Department of Radiology, the First Affiliated Hospital of Guangzhou University of 
      Chinese Medicine, Guangzhou, China. lysogood@126.com.
LA  - eng
GR  - Grant No. 81920108019/National Natural Science Foundation of China/
GR  - Grant No. 81920108019/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20230620
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
SB  - IM
OTO - NOTNLM
OT  - Cognitive function.
OT  - Resting state
OT  - Type 2 diabetes mellitus
OT  - cerebral blood flow
EDAT- 2023/06/21 01:07
MHDA- 2023/06/21 01:07
CRDT- 2023/06/20 23:33
PHST- 2022/08/07 00:00 [received]
PHST- 2023/02/25 00:00 [accepted]
PHST- 2023/06/21 01:07 [medline]
PHST- 2023/06/21 01:07 [pubmed]
PHST- 2023/06/20 23:33 [entrez]
AID - 10.1007/s12020-023-03342-6 [pii]
AID - 10.1007/s12020-023-03342-6 [doi]
PST - aheadofprint
SO  - Endocrine. 2023 Jun 20. doi: 10.1007/s12020-023-03342-6.