PMID- 37341066
OWN - NLM
STAT- MEDLINE
DCOM- 20230901
LR  - 20230902
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 12
IP  - 15
DP  - 2023 Aug
TI  - MCP-1 expression in breast cancer and its association with distant relapse.
PG  - 16221-16230
LID - 10.1002/cam4.6284 [doi]
AB  - BACKGROUND: Distant relapse of breast cancer complicates management of the 
      disease and accounts for 90% of breast cancer-related deaths. Monocyte 
      chemoattractant protein-1 (MCP-1) has critical roles in breast cancer progression 
      and is widely accepted as a pro-metastatic chemokine. METHODS: This study 
      explored MCP-1 expression in the primary tumour of 251 breast cancer patients. A 
      simplified 'histoscore' was used to determine if each tumour had high or low 
      expression of MCP-1. Patient breast cancers were retrospectively staged based on 
      available patient data. p < 0.05 was used to determine significance and changes 
      in hazard ratios between models were considered. RESULTS: Low MCP-1 expression in 
      the primary tumour was associated with breast cancer-related death with distant 
      relapse in ER- breast cancers (p < 0.01); however, this was likely a result of 
      most low MCP-1-expressing ER- breast cancers being Stage III or Stage IV, with 
      high MCP-1 expression in the primary tumour significantly correlated with Stage I 
      breast cancers (p < 0.05). Expression of MCP-1 in the primary ER- tumours varied 
      across Stage I, II, III and IV and we highlighted a switch in MCP-1 expression 
      from high in Stage I ER- cancers to low in Stage IV ER- cancers. CONCLUSION: This 
      study has emphasised a critical need for further investigation into MCP-1's role 
      in breast cancer progression and improved characterisation of MCP-1 in breast 
      cancers, particularly in light of the development of anti-MCP-1, anti-metastatic 
      therapies.
CI  - (c) 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Mulholland, Bridie S
AU  - Mulholland BS
AUID- ORCID: 0000-0003-3640-5811
AD  - Graduate School of Medicine, Faculty of Science, Medicine and Health, University 
      of Wollongong, Wollongong, New South Wales, Australia.
AD  - Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, 
      University of Sydney, Camperdown, New South Wales, Australia.
FAU - Hofstee, Pierre
AU  - Hofstee P
AUID- ORCID: 0000-0002-4716-4016
AD  - Graduate School of Medicine, Faculty of Science, Medicine and Health, University 
      of Wollongong, Wollongong, New South Wales, Australia.
AD  - The Tweed Hospital, Northern New South Wales Local Health District, Tweed Heads, 
      New South Wales, Australia.
FAU - Millar, Ewan K A
AU  - Millar EKA
AD  - St George and Sutherland Clinical Campuses, School of Clinical Medicine, UNSW 
      Medicine and Health, University of New South Wales, Sydney, New South Wales, 
      Australia.
AD  - Department of Anatomical Pathology, NSW Health Pathology, St George Hospital, 
      Kogarah, Australia.
AD  - Translational Breast Cancer Research Group, Cancer Ecosystems Program, Garvan 
      Institute of Medical Research, Sydney, New South Wales, Australia.
FAU - Bliuc, Dana
AU  - Bliuc D
AUID- ORCID: 0000-0001-9682-2313
AD  - Bone Microenvironment Group, Skeletal Diseases Program, Garvan Institute of 
      Medical Research, Sydney, New South Wales, Australia.
FAU - O'Toole, Sandra
AU  - O'Toole S
AD  - Translational Breast Cancer Research Group, Cancer Ecosystems Program, Garvan 
      Institute of Medical Research, Sydney, New South Wales, Australia.
AD  - Department of Tissue Pathology and Diagnostic Pathology, Royal Prince Alfred 
      Hospital, Camperdown, New South Wales, Australia.
AD  - Sydney Medical School, Faculty of Medicine and Health, University of Sydney, 
      Camperdown, New South Wales, Australia.
FAU - Forwood, Mark R
AU  - Forwood MR
AUID- ORCID: 0000-0002-9963-1616
AD  - School of Pharmacy and Medical Sciences, Menzies Health Institute Queensland, 
      Griffith University, Gold Coast, Queensland, Australia.
FAU - McDonald, Michelle M
AU  - McDonald MM
AUID- ORCID: 0000-0002-3928-2506
AD  - Bone Microenvironment Group, Skeletal Diseases Program, Garvan Institute of 
      Medical Research, Sydney, New South Wales, Australia.
AD  - School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, 
      Camperdown, New South Wales, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230621
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Breast Neoplasms/pathology
MH  - Chemokine CCL2/genetics
MH  - Retrospective Studies
MH  - Neoplasm Recurrence, Local/pathology
MH  - Breast/pathology
MH  - Chronic Disease
PMC - PMC10469641
OTO - NOTNLM
OT  - CCL2
OT  - metastasis
OT  - neoplasm
OT  - protein
OT  - tumour
COIS- The authors declare that they have no competing interests.
EDAT- 2023/06/21 06:42
MHDA- 2023/09/01 06:43
PMCR- 2023/06/21
CRDT- 2023/06/21 05:53
PHST- 2023/06/06 00:00 [revised]
PHST- 2023/02/09 00:00 [received]
PHST- 2023/06/12 00:00 [accepted]
PHST- 2023/09/01 06:43 [medline]
PHST- 2023/06/21 06:42 [pubmed]
PHST- 2023/06/21 05:53 [entrez]
PHST- 2023/06/21 00:00 [pmc-release]
AID - CAM46284 [pii]
AID - 10.1002/cam4.6284 [doi]
PST - ppublish
SO  - Cancer Med. 2023 Aug;12(15):16221-16230. doi: 10.1002/cam4.6284. Epub 2023 Jun 
      21.