PMID- 37342581
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 6
DP  - 2023 Jun
TI  - Analysis of 16 mycotoxins in genuine traditional Chinese medicine for five 
      medicinal parts: Classification of analytical method based on PANI@CS 
      extraction-UPLC-MS/MS.
PG  - e17027
LID - 10.1016/j.heliyon.2023.e17027 [doi]
LID - e17027
AB  - A novel PANI@CS solid-phase dispersive extractant combined with ultra-performance 
      liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed for the 
      first time, which was used for high-throughput, multi-component, real-time online 
      rapid pretreatment and quantitative classification of 16 mycotoxins from five 
      different medicinal parts of 13 genuine traditional Chinese medicines (TCMs). 
      Ultra performance liquid chromatography combined with triple quadrupole mass 
      spectrometry was used for separation and ESI detection. An internal standard 
      isotope matching calibration was used for quantification purposes to compensate 
      for matrix effects. The limits of detection (LOD) of 16 mycotoxins ranged from 
      0.1 to 6.0 mug/kg. The linear coefficients (R(2)) were >/=0.996 in the linear range 
      from 10.0 to 200 mug/L. The recoveries of the 16 mycotoxins ranged from 90.1% to 
      105.8%, and the relative standard deviations (RSDs) ranged from 1.3% to 4.1%. 
      Thirteen TCMs from five representative medicinal parts were selected and tested 
      under the best sample preparation procedure and chromatographic analysis 
      conditions. The results showed that the method could improve the sensitivity and 
      accuracy of the sample analysis, improve the selectivity and reproducibility of 
      the decolorization and purification of TCMs, which is suitable for the practical 
      application of mycotoxin in trace analysis. This method can also provide a new 
      idea for accurate, efficient, rapid and multi-component online detection of 
      mycotoxins for quality and safety control of TCMs.
CI  - (c) 2023 The Author(s).
FAU - Guo, Xinying
AU  - Guo X
AD  - Nantong Center for Disease Control and Prevention, Nantong, PR China.
AD  - Nantong Key Laboratory of Food Hygiene, Nantong Food Safety Testing Center, 
      Nantong, PR China.
FAU - Chen, Feng
AU  - Chen F
AD  - Nantong Center for Disease Control and Prevention, Nantong, PR China.
AD  - Nantong Key Laboratory of Food Hygiene, Nantong Food Safety Testing Center, 
      Nantong, PR China.
FAU - Zhang, Weibing
AU  - Zhang W
AD  - Nantong Center for Disease Control and Prevention, Nantong, PR China.
AD  - Nantong Key Laboratory of Food Hygiene, Nantong Food Safety Testing Center, 
      Nantong, PR China.
AD  - Nantong Teaching and Research Practice Base of Public Health and Preventive 
      Medicine of Lanzhou University,Nantong, PR China.
LA  - eng
PT  - Journal Article
DEP - 20230610
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10277462
OTO - NOTNLM
OT  - Genuine traditional Chinese medicine
OT  - Medicinal parts
OT  - Mycotoxins
OT  - PANI@CS extraction
OT  - UPLC-MS/MS
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/06/21 19:15
MHDA- 2023/06/21 19:16
PMCR- 2023/06/10
CRDT- 2023/06/21 12:04
PHST- 2023/02/19 00:00 [received]
PHST- 2023/06/02 00:00 [revised]
PHST- 2023/06/05 00:00 [accepted]
PHST- 2023/06/21 19:16 [medline]
PHST- 2023/06/21 19:15 [pubmed]
PHST- 2023/06/21 12:04 [entrez]
PHST- 2023/06/10 00:00 [pmc-release]
AID - S2405-8440(23)04235-4 [pii]
AID - e17027 [pii]
AID - 10.1016/j.heliyon.2023.e17027 [doi]
PST - epublish
SO  - Heliyon. 2023 Jun 10;9(6):e17027. doi: 10.1016/j.heliyon.2023.e17027. eCollection 
      2023 Jun.