PMID- 37342978
OWN - NLM
STAT- MEDLINE
DCOM- 20231101
LR  - 20231106
IS  - 1668-3501 (Electronic)
IS  - 0325-0075 (Linking)
VI  - 121
IP  - 6
DP  - 2023 Dec 1
TI  - Cow's milk allergy: Can oral food challenges be avoided? A probabilistic analysis 
      based on clinical data.
PG  - e202202850
LID - 10.5546/aap.2022-02850.eng [doi]
AB  - Introduction. The oral food challenge (OFC) for the diagnosis of cow's milk 
      protein allergy (CMPA) poses risks and requires resources. Our objective was to 
      assess conditions and complementary tests used to identify a high probability of 
      CMPA. Population and methods. Secondary analysis of a study of patients seen at a 
      unit of allergy between 2015 and 2018. Pre-testing probabilities associated with 
      symptoms and their combinations and post-testing probabilities after skin prick 
      testing and serum immunoglobulin E (IgE) levels were determined. Results. The 
      data from 239 patients were assessed. A probability greater than 95% was observed 
      for angioedema and a combination of urticaria and vomiting. Based on the cut-off 
      points proposed by Calvani et al., the combination of vomiting with rhinitis, 
      without angioedema, also exceeded 95%. Conclusion. A methodology is provided to 
      identify patients in whom CMPA may be diagnosed without an OFC.
CI  - Sociedad Argentina de Pediatria.
FAU - Diaz, Maria C
AU  - Diaz MC
AUID- ORCID: 0000-0003-1591-4457
AD  - Unit of Allergy, Hospital General de Ninos "Pedro de Elizalde", City of Buenos 
      Aires, Argentina.
FAU - Slullitel, Pablo
AU  - Slullitel P
AUID- ORCID: 0000-0001-7262-4603
AD  - Unit of Allergy, Hospital General de Ninos "Pedro de Elizalde", City of Buenos 
      Aires, Argentina.
FAU - Souza, Maria V
AU  - Souza MV
AUID- ORCID: 0000-0003-0256-7898
AD  - Unit of Allergy, Hospital General de Ninos "Pedro de Elizalde", City of Buenos 
      Aires, Argentina.
LA  - eng
LA  - spa
PT  - Journal Article
TT  - Alergia a la leche de vaca:  inverted question markse pueden evitar las pruebas de provocacion oral? Un 
      analisis probabilistico basado en datos clinicos.
DEP - 20230629
PL  - Argentina
TA  - Arch Argent Pediatr
JT  - Archivos argentinos de pediatria
JID - 0372460
RN  - 0 (Milk Proteins)
SB  - IM
MH  - Female
MH  - Animals
MH  - Cattle
MH  - Humans
MH  - Infant
MH  - *Milk Hypersensitivity/diagnosis/epidemiology
MH  - Skin Tests/methods
MH  - *Angioedema/complications
MH  - Milk Proteins/adverse effects
MH  - Vomiting
OTO - NOTNLM
OT  - clinical diagnosis
OT  - milk allergy
OT  - predictive value of tests
EDAT- 2023/06/21 19:15
MHDA- 2023/11/01 12:43
CRDT- 2023/06/21 13:09
PHST- 2023/11/01 12:43 [medline]
PHST- 2023/06/21 19:15 [pubmed]
PHST- 2023/06/21 13:09 [entrez]
AID - 10.5546/aap.2022-02850.eng [doi]
PST - ppublish
SO  - Arch Argent Pediatr. 2023 Dec 1;121(6):e202202850. doi: 
      10.5546/aap.2022-02850.eng. Epub 2023 Jun 29.