PMID- 3734400
OWN - NLM
STAT- MEDLINE
DCOM- 19860916
LR  - 20190912
IS  - 0022-149X (Print)
IS  - 0022-149X (Linking)
VI  - 60
IP  - 2
DP  - 1986 Jun
TI  - Attempted vaccination of jirds (Meriones unguiculatus) against Brugia pahangi 
      with radiation attenuated infective larvae.
PG  - 149-55
AB  - Jirds were vaccinated by three to five subcutaneous (SC) injections of infective 
      larvae of Brugia pahangi which had been irradiated at 25, 45 or 90 krads from a 
      60Co source. They were challenged either SC or intraperitoneally. Vaccination 
      with four doses of 50 larvae irradiated with 25 krads produced 49.3% resistance 
      to IP challenge worms and 39.8% against SC challenge worms. Five doses of larvae 
      irradiated with 45 krads produced 62% resistance to SC challenge. Three doses of 
      larvae irradiated with 90 krads produced 74.9% resistance to SC challenge and 
      five doses produced 76.2% resistance. The reasons why irradiated larvae produce 
      resistance whereas normal larvae do not are discussed.
FAU - Chusattayanond, W
AU  - Chusattayanond W
FAU - Denham, D A
AU  - Denham DA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Helminthol
JT  - Journal of helminthology
JID - 2985115R
RN  - 0 (Vaccines, Attenuated)
SB  - IM
MH  - Animals
MH  - Brugia/*immunology/radiation effects
MH  - Elephantiasis, Filarial/*prevention & control
MH  - Female
MH  - Gerbillinae
MH  - Larva
MH  - Lymphedema/*prevention & control
MH  - Male
MH  - *Vaccination
MH  - *Vaccines, Attenuated
EDAT- 1986/06/01 00:00
MHDA- 1986/06/01 00:01
CRDT- 1986/06/01 00:00
PHST- 1986/06/01 00:00 [pubmed]
PHST- 1986/06/01 00:01 [medline]
PHST- 1986/06/01 00:00 [entrez]
AID - 10.1017/s0022149x00008397 [doi]
PST - ppublish
SO  - J Helminthol. 1986 Jun;60(2):149-55. doi: 10.1017/s0022149x00008397.