PMID- 37344083
OWN - NLM
STAT- MEDLINE
DCOM- 20230623
LR  - 20230625
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 56
DP  - 2023 Aug
TI  - Body composition, lipid profile and clinical parameters are predictors of 
      prognosis in patients with heart failure: Two-year follow-up.
PG  - 52-58
LID - S2405-4577(23)00122-5 [pii]
LID - 10.1016/j.clnesp.2023.04.029 [doi]
AB  - BACKGROUND: Heart failure (HF) is a complex syndrome that leads to changes in 
      body composition and eventually results in unfavorable outcomes. AIM: This study 
      aimed to evaluate body composition, lipid profiles and clinical parameters of 
      patients with HF, and their associations with both survival and unfavorable 
      clinical outcomes. METHODS: This prospective cohort study included 94 adults and 
      older people with HF. Body composition was assessed by bioelectrical impedance 
      analysis (BIA). Anthropometric variables and lipid profile were also evaluated. 
      Electronic medical records were checked to collect information on clinical 
      outcomes (mortality and hospitalization), considering a follow-up period of 24 
      months. Survival was calculated using the Kaplan-Meier estimate, and the curves 
      compared using Log-Rank. The death risk rate (Hazard Ratio, HR) was calculated 
      using Cox's univariate models. RESULTS: Mean age was 55.1 (13.9) years and there 
      was a higher frequency of males. There was a predominance of HF with reduced 
      ejection fraction, and ischemic etiology. Patients with New York Heart 
      Association (NYHA) functional classification I/II had a better overall survival 
      rate at 24 months than those with NYHA III/IV (univariate HR 4.93 (1.76-13.82); 
      p = 0.001). Greater survival rates were found in patients without chronic kidney 
      disease (CKD) (univariate HR 2.93 (1.59-5.39); p = 0.01). In the multivariate 
      analyses, both dyslipidemia (adjusted HR 3.84 (1.22-12.00); p = 0.021) and 
      increased fat mass index (FMI) were associated with overall survival rate 
      (adjusted HR 3.59 (1, 10-11.74); p = 0.034). CONCLUSION: The severity of HF 
      symptoms and the presence of chronic kidney disease are associated with higher 
      mortality. Increased fat mass index and dyslipidemia are predictors of favorable 
      outcomes in this population.
CI  - Copyright (c) 2023 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Paixao da Silva, Eduardo
AU  - Paixao da Silva E
AD  - Multiprofessional Residency in Health - Cardiology, Onofre Lopes University 
      Hospital, Federal University of Rio Grande Do Norte (EPS, RRSA, RVZD, NRDL, 
      MMGDL, KCMSE), Brazil.
FAU - Ranielly Dos Santos Avelino, Regina
AU  - Ranielly Dos Santos Avelino R
AD  - Multiprofessional Residency in Health - Cardiology, Onofre Lopes University 
      Hospital, Federal University of Rio Grande Do Norte (EPS, RRSA, RVZD, NRDL, 
      MMGDL, KCMSE), Brazil.
FAU - Zuza Diniz, Rosiane Viana
AU  - Zuza Diniz RV
AD  - Multiprofessional Residency in Health - Cardiology, Onofre Lopes University 
      Hospital, Federal University of Rio Grande Do Norte (EPS, RRSA, RVZD, NRDL, 
      MMGDL, KCMSE), Brazil; Department of Clinical Medicine, Health Sciences Center, 
      Federal University of Rio Grande Do Norte (RVZD), Brazil.
FAU - Dantas de Lira, Niethia Regina
AU  - Dantas de Lira NR
AD  - Multiprofessional Residency in Health - Cardiology, Onofre Lopes University 
      Hospital, Federal University of Rio Grande Do Norte (EPS, RRSA, RVZD, NRDL, 
      MMGDL, KCMSE), Brazil; Brazilian Hospital Services Company. Onofre Lopes 
      University Hospital, Health Sciences Center, Federal University of Rio Grande Do 
      Norte (NRDL), Brazil.
FAU - Monteiro Lourenco Queiroz, Salomao Israel
AU  - Monteiro Lourenco Queiroz SI
AD  - Postgraduate Program in Collective Health, Health Sciences Center, Federal 
      University of Rio Grande Do Norte (SIMLQ), Brazil.
FAU - Gomes Dantas Lopes, Marcia Marilia
AU  - Gomes Dantas Lopes MM
AD  - Multiprofessional Residency in Health - Cardiology, Onofre Lopes University 
      Hospital, Federal University of Rio Grande Do Norte (EPS, RRSA, RVZD, NRDL, 
      MMGDL, KCMSE), Brazil; Department of Nutrition, Health Sciences Center, Federal 
      University of Rio Grande Do Norte (MMGDL, KCMSE), Brazil.
FAU - Mauricio Sena-Evangelista, Karine Cavalcanti
AU  - Mauricio Sena-Evangelista KC
AD  - Multiprofessional Residency in Health - Cardiology, Onofre Lopes University 
      Hospital, Federal University of Rio Grande Do Norte (EPS, RRSA, RVZD, NRDL, 
      MMGDL, KCMSE), Brazil; Department of Nutrition, Health Sciences Center, Federal 
      University of Rio Grande Do Norte (MMGDL, KCMSE), Brazil. Electronic address: 
      karine.sena@ufrn.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230504
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Lipids)
SB  - IM
MH  - Male
MH  - Adult
MH  - Humans
MH  - Aged
MH  - Middle Aged
MH  - Follow-Up Studies
MH  - Prospective Studies
MH  - Prognosis
MH  - *Renal Insufficiency, Chronic/complications
MH  - *Heart Failure/diagnosis
MH  - Body Composition
MH  - Lipids
OTO - NOTNLM
OT  - Body composition
OT  - Clinical outcomes
OT  - Dyslipidemia
OT  - Fat mass index
OT  - Heart failure
OT  - Obesity
COIS- Declaration of competing interest The authors declare no conflicts of interest.
EDAT- 2023/06/22 01:07
MHDA- 2023/06/23 06:42
CRDT- 2023/06/21 20:57
PHST- 2022/09/11 00:00 [received]
PHST- 2023/04/16 00:00 [revised]
PHST- 2023/04/28 00:00 [accepted]
PHST- 2023/06/23 06:42 [medline]
PHST- 2023/06/22 01:07 [pubmed]
PHST- 2023/06/21 20:57 [entrez]
AID - S2405-4577(23)00122-5 [pii]
AID - 10.1016/j.clnesp.2023.04.029 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2023 Aug;56:52-58. doi: 10.1016/j.clnesp.2023.04.029. Epub 2023 
      May 4.