PMID- 37345059
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230701
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 10
DP  - 2023 May 11
TI  - The Role of the p16 and p53 Tumor Suppressor Proteins and Viral HPV16 E6 and E7 
      Oncoproteins in the Assessment of Survival in Patients with Head and Neck Cancers 
      Associated with Human Papillomavirus Infections.
LID - 10.3390/cancers15102722 [doi]
LID - 2722
AB  - The role of HPV in the survival prognosis of patients with head and neck squamous 
      cell carcinoma, especially patients with laryngeal squamous cell carcinoma (LSCC) 
      and hypopharyngeal squamous cell carcinoma (HPSCC), is still somewhat ambiguous. 
      The present study aimed to explore the significance of tumor suppressor proteins 
      and HPV16 E6 and E7 oncoproteins in the assessment of survival in patients with 
      oropharyngeal squamous cell carcinoma (OPSCC), LSCC, and HPSCC associated with 
      high-risk (HR-) and low-risk (LR-) HPV infections. By utilizing molecular and 
      immunohistochemical investigations of HNSCC samples and patient data, univariate 
      and multivariate survival analyses were conducted. The presence of HPV DNA (LR- 
      and HR-HPV) was associated with a better 5-year OS and DSS for OPSCC and LSCC. 
      The IHC overexpression of HPV16 E6 protein and p16 protein was associated with 
      better survival in the univariate (for OPSCC) and multivariate (OPSCC and HPSCC) 
      survival analyses. The overexpression of p53 was associated with better survival 
      in OPSCC. HPV infection plays a significant role in the tumorigenesis of HNSCC, 
      and the immunohistochemical assessment of HPV16 E6 protein expression should be 
      interpreted as a useful prognostic marker for OPSCC and HPSCC.
FAU - Lifsics, Andrejs
AU  - Lifsics A
AUID- ORCID: 0000-0002-3546-5612
AD  - Department of Otorhinolaryngology, Riga Stradins University, Pilsonu 13, LV-1002 
      Riga, Latvia.
FAU - Cistjakovs, Maksims
AU  - Cistjakovs M
AUID- ORCID: 0000-0001-6883-9935
AD  - Institute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, 
      LV-1067 Riga, Latvia.
FAU - Sokolovska, Liba
AU  - Sokolovska L
AUID- ORCID: 0000-0002-5820-1783
AD  - Institute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, 
      LV-1067 Riga, Latvia.
FAU - Deksnis, Renars
AU  - Deksnis R
AUID- ORCID: 0000-0001-5742-6203
AD  - Department of Otorhinolaryngology, Riga Stradins University, Pilsonu 13, LV-1002 
      Riga, Latvia.
FAU - Murovska, Modra
AU  - Murovska M
AUID- ORCID: 0000-0003-0971-1784
AD  - Institute of Microbiology and Virology, Riga Stradins University, Ratsupites 5, 
      LV-1067 Riga, Latvia.
FAU - Groma, Valerija
AU  - Groma V
AUID- ORCID: 0000-0003-2616-2668
AD  - Institute of Anatomy and Anthropology, Riga Stradins University, Kronvalda blvd 
      9, LV-1010 Riga, Latvia.
LA  - eng
GR  - 8.2.2.0/20/l/004/European Social Fund and the Latvian state budget/
PT  - Journal Article
DEP - 20230511
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10216029
OTO - NOTNLM
OT  - E6/E7 viral oncoproteins
OT  - HPV
OT  - PCR
OT  - hypopharynx
OT  - immunohistochemistry
OT  - larynx
OT  - oropharynx
OT  - p16
OT  - p53
OT  - squamous cell carcinoma
OT  - survival analysis
COIS- The authors declare no conflict of interest.
EDAT- 2023/06/22 06:41
MHDA- 2023/06/22 06:42
PMCR- 2023/05/11
CRDT- 2023/06/22 01:00
PHST- 2023/03/26 00:00 [received]
PHST- 2023/05/03 00:00 [revised]
PHST- 2023/05/09 00:00 [accepted]
PHST- 2023/06/22 06:42 [medline]
PHST- 2023/06/22 06:41 [pubmed]
PHST- 2023/06/22 01:00 [entrez]
PHST- 2023/05/11 00:00 [pmc-release]
AID - cancers15102722 [pii]
AID - cancers-15-02722 [pii]
AID - 10.3390/cancers15102722 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 May 11;15(10):2722. doi: 10.3390/cancers15102722.