PMID- 37346078
OWN - NLM
STAT- MEDLINE
DCOM- 20230626
LR  - 20231116
IS  - 1178-2005 (Electronic)
IS  - 1176-9106 (Print)
IS  - 1176-9106 (Linking)
VI  - 18
DP  - 2023
TI  - Physical Activity, Exercise Capacity and Sedentary Behavior in People with 
      Alpha-1 Antitrypsin Deficiency: A Scoping Review.
PG  - 1231-1250
LID - 10.2147/COPD.S389001 [doi]
AB  - Alpha-1 antitrypsin deficiency (AATD) is a hereditary disorder and a genetic risk 
      factor for chronic obstructive pulmonary disease (COPD). Physical activity (PA) 
      is important for the prevention and treatment of chronic disease. Little is known 
      about PA in people with AATD. Therefore, we aimed to map the research undertaken 
      to improve and/or measure PA, sedentary behaviour (SB) or exercise in people with 
      AATD. Searches were conducted in CINAHL, Medline, EMBASE and clinical trial 
      databases for studies published in 2021. Databases were searched for keywords 
      (physical activity, AATD, exercise, sedentary behavior) as well as synonyms of 
      these terms, which were connected using Boolean operators. The search yielded 360 
      records; 37 records were included for review. All included studies (n = 37) 
      assessed exercise capacity; 22 studies reported the use of the six-minute walk 
      test, the incremental shuttle walk test and cardiopulmonary exercise testing were 
      reported in three studies each. Other objective measures of exercise capacity 
      included a submaximal treadmill test, the Naughton protocol treadmill test, cycle 
      ergometer maximal test, endurance shuttle walk test, constant cycle work rate 
      test, a peak work rate test and the number of flights of stairs a participant was 
      able to walk without stopping. A number of participant self-reported measures of 
      exercise capacity were noted. Only one study aimed to analyze the effects of an 
      intensive fitness intervention on daily PA. One further study reported on an 
      exercise intervention and objectively measured PA at baseline. No studies 
      measured SB. The assessment of PA and use of PA as an intervention in AATD is 
      limited, and research into SB absent. Future research should measure PA and SB 
      levels in people with AATD and explore interventions to enhance PA in this 
      susceptible population.
CI  - (c) 2023 O'Shea et al.
FAU - O'Shea, Orlagh
AU  - O'Shea O
AUID- ORCID: 0000-0003-2961-6717
AD  - School of Physiotherapy, Royal College of Surgeons in Ireland University of 
      Medicine and Health Sciences, Dublin 2, Ireland.
FAU - Casey, Saidhbhe
AU  - Casey S
AD  - School of Physiotherapy, Royal College of Surgeons in Ireland University of 
      Medicine and Health Sciences, Dublin 2, Ireland.
FAU - Giblin, Ciaran
AU  - Giblin C
AD  - School of Physiotherapy, Royal College of Surgeons in Ireland University of 
      Medicine and Health Sciences, Dublin 2, Ireland.
FAU - Stephenson, Aoife
AU  - Stephenson A
AD  - School of Physiotherapy, Royal College of Surgeons in Ireland University of 
      Medicine and Health Sciences, Dublin 2, Ireland.
AD  - School of Health Sciences, University of Southampton, Southampton, UK.
FAU - Carroll, Tomas P
AU  - Carroll TP
AD  - Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of 
      Surgeons in Ireland University of Medicine and Health Sciences, Beaumont 
      Hospital, Dublin 9, Ireland.
FAU - McElvaney, Noel G
AU  - McElvaney NG
AD  - Irish Centre for Genetic Lung Disease, Department of Medicine, Royal College of 
      Surgeons in Ireland University of Medicine and Health Sciences, Beaumont 
      Hospital, Dublin 9, Ireland.
FAU - McDonough, Suzanne M
AU  - McDonough SM
AD  - School of Physiotherapy, Royal College of Surgeons in Ireland University of 
      Medicine and Health Sciences, Dublin 2, Ireland.
AD  - School of Health Sciences, University of Southampton, Southampton, UK.
AD  - Centre for Health and Rehabilitation Technologies, School of Health Sciences, 
      Ulster University, Newtownabbey, BT37 0QB, UK.
AD  - School of Physiotherapy, University of Otago, Dunedin, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230616
PL  - New Zealand
TA  - Int J Chron Obstruct Pulmon Dis
JT  - International journal of chronic obstructive pulmonary disease
JID - 101273481
RN  - 0 (alpha 1-Antitrypsin)
SB  - IM
MH  - Humans
MH  - Sedentary Behavior
MH  - *Pulmonary Disease, Chronic Obstructive/diagnosis/therapy
MH  - Exercise Tolerance
MH  - Exercise
MH  - *alpha 1-Antitrypsin Deficiency/diagnosis/genetics/therapy
MH  - alpha 1-Antitrypsin
PMC - PMC10281283
OTO - NOTNLM
OT  - AATD
OT  - COPD
OT  - exercise capacity
OT  - lung disease
OT  - physical activity measurement
OT  - sedentary behavior
COIS- Professor Noel G McElvaney reports grants from Grifols, Csl Behring; advisory 
      board for vertex and inhibrx, outside the submitted work. The authors report no 
      other conflicts of interest in this work.
EDAT- 2023/06/22 13:09
MHDA- 2023/06/26 06:41
PMCR- 2023/06/16
CRDT- 2023/06/22 09:45
PHST- 2022/09/15 00:00 [received]
PHST- 2023/03/07 00:00 [accepted]
PHST- 2023/06/26 06:41 [medline]
PHST- 2023/06/22 13:09 [pubmed]
PHST- 2023/06/22 09:45 [entrez]
PHST- 2023/06/16 00:00 [pmc-release]
AID - 389001 [pii]
AID - 10.2147/COPD.S389001 [doi]
PST - epublish
SO  - Int J Chron Obstruct Pulmon Dis. 2023 Jun 16;18:1231-1250. doi: 
      10.2147/COPD.S389001. eCollection 2023.