PMID- 37348291
OWN - NLM
STAT- MEDLINE
DCOM- 20231011
LR  - 20231011
IS  - 1872-7506 (Electronic)
IS  - 0925-4927 (Print)
IS  - 0925-4927 (Linking)
VI  - 333
DP  - 2023 Aug
TI  - Altered functional connectivity between cortical networks associated with 
      inhibitory control in trauma-exposed females.
PG  - 111671
LID - S0925-4927(23)00081-1 [pii]
LID - 10.1016/j.pscychresns.2023.111671 [doi]
AB  - Post-traumatic stress disorder (PTSD) is associated with impaired inhibitory 
      control and alterations in large-scale brain network connectivity. However, few 
      studies to date have examined the construct of inhibitory control as it relates 
      to resting-state functional connectivity (rsFC) in a population with PTSD or 
      trauma-exposure. The present study investigated the relationship between impaired 
      inhibitory control and rsFC within the default mode network (DMN), central 
      executive network (CEN), and salience network (SN) in a sample of females exposed 
      to interpersonal trauma with and without PTSD (n = 67). Participants completed a 
      classic Color-Word Stroop task as a measure of inhibitory control and two 
      resting-state fMRI scans. We conducted voxelwise rsFC analyses with seed regions 
      in the DMN, CEN, and SN and voxelwise linear regression analyses to examine the 
      relationship between inhibitory control and rsFC of these networks across the 
      sample. Better Stroop performance was negatively associated with total 
      self-reported PTSD symptoms. An analysis of PTSD symptom clusters indicated that 
      better Stroop performance was also associated with re-experiencing and 
      hyperarousal symptoms, but not avoidance PTSD symptoms. Decreased coupling 
      between the CEN and the DMN was associated with better inhibitory control in this 
      sample of trauma-exposed females. These findings lend support to the hypothesis 
      that efficient switching between these networks may contribute to better 
      performance on cognitive and attentional tasks in trauma-exposed individuals.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Yetter, Marissa
AU  - Yetter M
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, MO, 63121, USA, University of Missouri - St. Louis.
FAU - Philippi, Carissa L
AU  - Philippi CL
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, MO, 63121, USA, University of Missouri - St. Louis.
FAU - Bruce, Steven E
AU  - Bruce SE
AD  - Department of Psychological Sciences, University of Missouri-St. Louis, 1 
      University Blvd., St. Louis, MO, 63121, USA, University of Missouri - St. Louis. 
      Electronic address: steven.bruce@umsl.edu.
LA  - eng
GR  - K23 MH090366/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20230615
PL  - Netherlands
TA  - Psychiatry Res Neuroimaging
JT  - Psychiatry research. Neuroimaging
JID - 101723001
SB  - IM
MH  - Female
MH  - Humans
MH  - *Brain Mapping
MH  - Magnetic Resonance Imaging
MH  - *Neural Inhibition
MH  - *Stress Disorders, Post-Traumatic/pathology/physiopathology/psychology
MH  - *Stroop Test
MH  - *Cerebral Cortex/pathology/physiopathology
MH  - Avoidance Learning
MH  - Arousal
MH  - Adult
PMC - PMC10330570
MID - NIHMS1910247
OTO - NOTNLM
OT  - Classic Stroop
OT  - Functional connectivity
OT  - Inhibitory control
OT  - Post-traumatic stress disorder
COIS- Declaration of Competing Interest All authors must disclose any financial and 
      personal relationships with other people or organizations that could 
      inappropriately influence (bias) their work. Examples of potential competing 
      interests include employment, consultancies, stock ownership, honoraria, paid 
      expert testimony, patent applications/registrations, and grants or other funding. 
      Authors must disclose any interests in two places: 1. A summary declaration of 
      interest statement in the title page file (if double anonymized) or the 
      manuscript file (if single anonymized). If there are no interests to declare then 
      please state this: 'Declarations of interest: none'. 2. Detailed disclosures as 
      part of a separate Declaration of Interest form, which forms part of the 
      journal's official records. It is important for potential interests to be 
      declared in both places and that the information matches. More information.
EDAT- 2023/06/23 01:10
MHDA- 2023/07/07 06:42
PMCR- 2024/08/01
CRDT- 2023/06/22 18:06
PHST- 2023/01/29 00:00 [received]
PHST- 2023/04/18 00:00 [revised]
PHST- 2023/06/01 00:00 [accepted]
PHST- 2024/08/01 00:00 [pmc-release]
PHST- 2023/07/07 06:42 [medline]
PHST- 2023/06/23 01:10 [pubmed]
PHST- 2023/06/22 18:06 [entrez]
AID - S0925-4927(23)00081-1 [pii]
AID - 10.1016/j.pscychresns.2023.111671 [doi]
PST - ppublish
SO  - Psychiatry Res Neuroimaging. 2023 Aug;333:111671. doi: 
      10.1016/j.pscychresns.2023.111671. Epub 2023 Jun 15.